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UniProtKB/Swiss-Prot entry O34344


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SDPC_BACSU
Primary accession number O34344
Secondary accession numbers None
Integrated into Swiss-Prot on July 25, 2003
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Killing factor sdpC [Precursor]
Synonym Toxic peptide sdpC
Gene name
Name: sdpC
Synonyms: yvaY
OrderedLocusNames: BSU33770
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=168 / JH642;
Nakamura A., Grau R., Perego M., Hoch J.A.;
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
[3]
PROTEIN SEQUENCE OF 142-169, AND INVOLVEMENT IN THE INDUCTION OF SDPRI.
STRAIN=168 / PY79;
DOI=10.1126/science.1086462; PubMed=12817086 [NCBI, ExPASy, EBI, Israel, Japan]
Gonzalez-Pastor J.E., Hobbs E.C., Losick R.;
"Cannibalism by sporulating bacteria.";
Science 301:510-513(2003).
[4]
FUNCTION.
STRAIN=168 / PY79;
DOI=10.1016/j.cell.2005.11.041; PubMed=16469701 [NCBI, ExPASy, EBI, Israel, Japan]
Ellermeier C.D., Hobbs E.C., Gonzalez-Pastor J.E., Losick R.;
"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.";
Cell 124:549-559(2006).
[5]
REPRESSION BY ABRB AND ABH.
DOI=10.1128/JB.01081-07; PubMed=17720793 [NCBI, ExPASy, EBI, Israel, Japan]
Strauch M.A., Bobay B.G., Cavanagh J., Yao F., Wilson A., Le Breton Y.;
"Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.";
J. Bacteriol. 189:7720-7732(2007).
Comments
  • FUNCTION: Induces the lysis of other B.subtilis cells that have not entered the sporulation pathway, providing a source of nutrients to support sporulation. Its maturation is dependent on sdpA and sdpB. Also functions as a ligand, being able to bind to sdpI thereby triggering a signal transduction cascade that protects the cell against the toxic effects of its own sdpC.
  • SUBCELLULAR LOCATION: Secreted.
  • INDUCTION: By spo0A during nutrient starvation, through its direct negative control of abrB. Repressed by abrB during regular growth when nutrients are plentiful, in association with the transcriptional repressor abh.
  • WEB RESOURCE: Name=Protein Spotlight; Note=I'll have you for supper - Issue 90 of January 2008; URL="http://www.expasy.org/spotlight/back_issues/sptlt090.shtml";.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB006738; BAA21902.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99121; CAB15382.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B70029; B70029.
RefSeq NP_391257.1; -.
3D structure databases
ModBase O34344.
Enzyme and pathway databases
BioCyc BSUB224308:BSU3374-MON; -.
Organism-specific databases
SubtiList BG14076; sdpC. [Micado]
Family and domain databases
BLOCKS O34344.
Genome annotation databases
GeneID 936227; -.
GenomeReviews AL009126_GR; BSU33770.
KEGG bsu:BSU33770; -.
NMPDR fig|224308.1.peg.3383; -.
Phylogenomic databases
HOGENOM O34344; -.
Genome annotation databases
CMR O34344; BSU33770.
Other
ProtoNet O34344.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    32  32     Potential. 
CHAIN   33   203  171     Killing factor sdpC. PRO_0000013732
CONFLICT   161   161        Missing (in Ref. 3; AA sequence). 
Sequence information
Length: 203 AA [This is the length of the unprocessed precursor] Molecular weight: 22221 Da [This is the MW of the unprocessed precursor] CRC64: 4928C22C6AB4BEBC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKSKLLRLLI VSMVTILVFS LVGLSKESST SAKENHTFSG EDYFRGLLFG QGEVGKLISN 

        70         80         90        100        110        120 
DLDPKLVKEA NSTEGKKLVN DVVKFIKKDQ PQYMDELKQS IDSKDPKKLI ENMTKADQLI 

       130        140        150        160        170        180 
QKYAKKNENV KYSSNKVTPS CGLYAVCVAA GYLYVVGVNA VALQTAAAVT TAVWKYVAKY 

       190        200 
SSSASNNSDL EAAAAKTLKL IHQ 

O34344 in FASTA format

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