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UniProtKB/Swiss-Prot entry O25827


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AK_HELPY
Primary accession number O25827
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 47)
Name and origin of the protein
Protein name Aspartokinase
Synonyms EC 2.7.2.4
Aspartate kinase
Gene name
Name: lysC
OrderedLocusNames: HP_1229
From
Helicobacter pylori (Campylobacter pylori) [TaxID: 210] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000511; AAD08274.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E64673; E64673.
RefSeq NP_208021.1; -.
3D structure databases
ModBase O25827.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR001048; Asp/Glu/Uridylate_kinase.
IPR005260; Asp_kin_monofn.
IPR001341; Asp_kin_reg.
Graphical view of domain structure.
Gene3D G3DSA:3.40.1160.10; Aa_kinase; 1.
Pfam PF00696; AA_kinase; 1.
PF01842; ACT; 2.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00656; asp_kin_monofn; 1.
TIGR00657; asp_kinases; 1.
PROSITE PS00324; ASPARTOKINASE; 1.
BLOCKS O25827.
Genome annotation databases
GeneID 899013; -.
GenomeReviews AE000511_GR; HP_1229.
KEGG hpy:HP1229; -.
NMPDR fig|85962.1.peg.1217; -.
TIGR HP_1229; -.
Phylogenomic databases
HOGENOM O25827; -.
Other
ProtoNet O25827.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Kinase; Lysine biosynthesis; Repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   405  405     Aspartokinase. PRO_0000066677
DOMAIN   271   337  67     ACT 1. 
DOMAIN   344   400  57     ACT 2. 
Sequence information
Length: 405 AA [This is the length of the unprocessed precursor] Molecular weight: 44134 Da [This is the MW of the unprocessed precursor] CRC64: 74723D671FF49395 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLIVQKYGGT SMGSIERIHN VAQRVLESVT LGHQVVVVVS AMSGETDRLL EFGKNFSHNP 

        70         80         90        100        110        120 
NKREMDRIVS VGELVSSAAL SMALERYGHR AISLSGKEAG ILTSSHFQNA VIQSIDTKRI 

       130        140        150        160        170        180 
TELLEKNYIV VIAGFQGADI QGETTTLGRG GSDLSAVALA GALKAHLCEI YTDVDGVYTT 

       190        200        210        220        230        240 
DPRIEEKAQK IAQISYDEML ELASMGAKVL LNRSVELAKK LSVKLVTRNS FNHSEGTLIV 

       250        260        270        280        290        300 
AEKDFKGERM ETPIVSGIAL DKNQARVSME GVEDRPGIAA EIFGALAEYR INVDMIVQTI 

       310        320        330        340        350        360 
GRDGKTDLDF TIVKTQIEET KQALKPFLAQ MDSIDYDENI AKVSIVGVGM KSHSGVASIA 

       370        380        390        400 
FKALAKDNIN IMMISTSEIK ISVLIDIKYA ELAVRTLHAV YQLDQ 

O25827 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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