NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9271098 [NCBI, ExPASy, EBI, Israel, Japan]
Garcia I., Rodgers M., Lenne C., Rolland A., Sailland A., Matringe M.;
"Subcellular localization and purification of a p-hydroxyphenylpyruvate dioxygenase from cultured carrot cells and characterization of the corresponding cDNA.";
Biochem. J. 325:761-769(1997).

Comments

CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O₂ = homogentisate + CO₂.
COFACTOR: Binds 1 iron ion per subunit (By similarity).
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 3/6 .
PATHWAY: Context: Prenylquinones biosynthesis .
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the 4HPPD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U87257; AAC49815.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T14353; T14353.

3D structure databases

SMR

O23920; 32-430.

ModBase

O23920.

Family and domain databases

InterPro

IPR005956; 4OHPhenylPyrv_dOase.
IPR004360; Glyas_bleo-R_dOase.
Graphical view of domain structure.

PANTHER

PTHR11959; HPP_dOase; 1.

Pfam

PF00903; Glyoxalase; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF009283; HPP_dOase; 1.

TIGR01263; 4HPPD; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 442`	`442`	`4-hydroxyphenylpyruvate dioxygenase.`	`PRO_0000088398`
`METAL`	`219 219`		`Iron (By similarity).`
`METAL`	`301 301`		`Iron (By similarity).`
`METAL`	`387 387`		`Iron (By similarity).`

Sequence information

Length: 442 AA [This is the length of the unprocessed precursor]

Molecular weight: 48148 Da [This is the MW of the unprocessed precursor]

CRC64: A484AFFA267F7BF7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGKKQSEAEI LSSNSSNTSP ATFKLVGFNN FVRANPKSDH FAVKRFHHIE FWCGDATNTS 

        70         80         90        100        110        120 
RRFSWGLGMP LVAKSDLSTG NSVHASYLVR SANLSFVFTA PYSPSTTTSS GSAAIPSFSA 

       130        140        150        160        170        180 
SGFHSFAAKH GLAVRAIALE VADVAAAFEA SVARGARPAS APVELDDQAW LAEVELYGDV 

       190        200        210        220        230        240 
VLRFVSFGRE EGLFLPGFEA VEGTASFPDL DYGIRRLDHA VGNVTELGPV VEYIKGFTGF 

       250        260        270        280        290        300 
HEFAEFTAED VGTLESGLNS VVLANNEEMV LLPLNEPVYG TKRKSQIQTY LEHNEGAGVQ 

       310        320        330        340        350        360 
HLALVSEDIF RTLREMRKRS CLGGFEFMPS PPPTYYKNLK NRVGDVLSDE QIKECEDLGI 

       370        380        390        400        410        420 
LVDRDDQGTL LQIFTKPVGD RPTLFIEIIQ RVGCMLKDDA GQMYQKGGCG GFGKGNFSEL 

       430        440 
FKSIEEYEKT LEAKQITGSA AA

O23920 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools