[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1016/S0960-9822(06)00122-9; PubMed=9094314 [NCBI, ExPASy, EBI, Israel, Japan]
Alessi D.R.,
James S.R.,
Downes C.P.,
Holmes A.B.,
Gaffney P.R.J.,
Reese C.B.,
Cohen P.;
"Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha.";
Curr. Biol. 7:261-269(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1016/S0960-9822(06)00336-8; PubMed=9368760 [NCBI, ExPASy, EBI, Israel, Japan]
Alessi D.R.,
Deak M.,
Casamayor A.,
Caudwell F.B.,
Morrice N.A.,
Norman D.G.,
Gaffney P.R.J.,
Reese C.B.,
MacDougall C.N.,
Harbison D.,
Ashworth A.,
Bownes M.;
"3-phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.";
Curr. Biol. 7:776-789(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
TISSUE=Myeloid;
DOI=10.1126/science.279.5351.710; PubMed=9445477 [NCBI, ExPASy, EBI, Israel, Japan]
Stephens L.R.,
Anderson K.E.,
Stokoe D.,
Erdjument-Bromage H.,
Painter G.F.,
Holmes A.B.,
Gaffney P.R.J.,
Reese C.B.,
McCormick F.,
Tempst P.,
Coadwell W.J.,
Hawkins P.T.;
"Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.";
Science 279:710-714(1998).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Kidney;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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PROTEIN SEQUENCE OF 60-75; 87-100; 184-199; 239-257 AND 284-293, PHOSPHORYLATION AT SER-241, AND MASS SPECTROMETRY.
TISSUE=Embryonic kidney;
Bienvenut W.V.,
Waridel P.,
Quadroni M.;
Submitted (MAR-2009) to UniProtKB.
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[7]
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MUTAGENESIS OF ARG-474, AND ALTERNATIVE SPLICING.
DOI=10.1016/S0960-9822(98)70274-X; PubMed=9637919 [NCBI, ExPASy, EBI, Israel, Japan]
Anderson K.E.,
Coadwell W.J.,
Stephens L.R.,
Hawkins P.T.;
"Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B.";
Curr. Biol. 8:684-691(1998).
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[8]
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PHOSPHORYLATION AT SER-25; SER-241; SER-393; SER-396 AND SER-410, AND MUTAGENESIS OF SER-25; SER-241; SER-393; SER-396 AND SER-410.
DOI=10.1042/0264-6021:3420287; PubMed=10455013 [NCBI, ExPASy, EBI, Israel, Japan]
Casamayor A.,
Morrice N.A.,
Alessi D.R.;
"Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo.";
Biochem. J. 342:287-292(1999).
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[9]
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MUTAGENESIS OF ALA-277.
PubMed=10364160 [NCBI, ExPASy, EBI, Israel, Japan]
Paradis S.,
Ailion M.,
Toker A.,
Thomas J.H.,
Ruvkun G.;
"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.";
Genes Dev. 13:1438-1452(1999).
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[10]
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PHOSPHORYLATION AT TYR-9; SER-241; TYR-373 AND TYR-376, AND MUTAGENESIS OF TYR-9; TYR-373 AND TYR-376.
DOI=10.1074/jbc.M105916200; PubMed=11481331 [NCBI, ExPASy, EBI, Israel, Japan]
Park J.,
Hill M.M.,
Hess D.,
Brazil D.P.,
Hofsteenge J.,
Hemmings B.A.;
"Identification of tyrosine phosphorylation sites on 3-phosphoinositide-dependent protein kinase-1 (PDK1) and their role in regulating kinase activity.";
J. Biol. Chem. 276:37459-37471(2001).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-245, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, AND MASS SPECTROMETRY.
TISSUE=Pituitary;
DOI=10.1007/s11102-006-8916-x; PubMed=16807684 [NCBI, ExPASy, EBI, Israel, Japan]
Beranova-Giorgianni S.,
Zhao Y.,
Desiderio D.M.,
Giorgianni F.;
"Phosphoproteomic analysis of the human pituitary.";
Pituitary 9:109-120(2006).
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[14]
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INTERACTION WITH TUSC4.
DOI=10.1111/j.1349-7006.2008.00874.x; PubMed=18616680 [NCBI, ExPASy, EBI, Israel, Japan]
Kurata A.,
Katayama R.,
Watanabe T.,
Tsuruo T.,
Fujita N.;
"TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling.";
Cancer Sci. 99:1827-1834(2008).
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[15]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-37 AND SER-241, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[16]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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