[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A; 1B AND 2).
TISSUE=Colon;
PubMed=9187114 [NCBI, ExPASy, EBI, Israel, Japan]
Aburatani H.,
Hippo Y.,
Ishida T.,
Takashima R.,
Matsuba C.,
Kodama T.,
Takao M.,
Yasui A.,
Yamamoto K.,
Asano M.,
Fukasawa K.,
Yoshinari T.,
Inoue H.,
Otsuka E.,
Nishimura S.;
"Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.";
Cancer Res. 57:2151-2156(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
DOI=10.1073/pnas.94.14.7429; PubMed=9207108 [NCBI, ExPASy, EBI, Israel, Japan]
Rosenquist T.A.,
Zharkov D.O.,
Grollman A.P.;
"Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase.";
Proc. Natl. Acad. Sci. U.S.A. 94:7429-7434(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
DOI=10.1073/pnas.94.15.8016; PubMed=9223306 [NCBI, ExPASy, EBI, Israel, Japan]
Roldan-Arjona T.,
Wei Y.-F.,
Carter K.C.,
Klungland A.,
Anselmino C.,
Wang R.-P.,
Augustus M.,
Lindahl T.;
"Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase.";
Proc. Natl. Acad. Sci. U.S.A. 94:8016-8020(1997).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
DOI=10.1073/pnas.94.15.8010; PubMed=9223305 [NCBI, ExPASy, EBI, Israel, Japan]
Radicella J.P.,
Dherin C.,
Desmaze C.,
Fox M.S.,
Boiteux S.;
"Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae.";
Proc. Natl. Acad. Sci. U.S.A. 94:8010-8015(1997).
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[5]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A), ACTIVE SITE, AND MUTAGENESIS OF LYS-249.
DOI=10.1016/S0960-9822(06)00187-4; PubMed=9197244 [NCBI, ExPASy, EBI, Israel, Japan]
Lu R.,
Nash H.M.,
Verdine G.L.;
"A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer.";
Curr. Biol. 7:397-407(1997).
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[6]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
DOI=10.1038/sj.onc.1201139; PubMed=9190902 [NCBI, ExPASy, EBI, Israel, Japan]
Arai K.,
Morishita K.,
Shinmura K.,
Kohno T.,
Taniwaki M.,
Ohwada S.,
Yokota J.;
"Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage.";
Oncogene 14:2857-2861(1997).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
DOI=10.1084/jem.186.9.1547; PubMed=9348312 [NCBI, ExPASy, EBI, Israel, Japan]
Kuo F.C.,
Sklar J.L.;
"Augmented expression of a human gene for 8-oxoguanine DNA glycosylase (MutM) in B lymphocytes of the dark zone in lymph node germinal centers.";
J. Exp. Med. 186:1547-1556(1997).
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[8]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A).
DOI=10.1093/emboj/16.20.6314; PubMed=9321410 [NCBI, ExPASy, EBI, Israel, Japan]
Bjoras M.,
Luna L.,
Johnsen B.E.,
Hoff E.,
Haug T.,
Rognes T.,
Seeberg E.;
"Opposite base-dependent reactions of a human base excision repair enzyme on DNA containing 7,8-dihydro-8-oxoguanine and abasic sites.";
EMBO J. 16:6314-6322(1997).
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[9]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Dhenaut A.,
Boiteux S.,
Radicella J.;
"Genomic structure and promoter characterization of the human 8-OH-guanine glycosylase gene (OGG1) gene.";
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
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[10]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
PubMed=10449904 [NCBI, ExPASy, EBI, Israel, Japan]
Ishida T.,
Hippo Y.,
Nakahori Y.,
Matsushita I.,
Kodama T.,
Nishimura S.,
Aburatani H.;
"Structure and chromosome location of human OGG1.";
Cytogenet. Cell Genet. 85:232-236(1999).
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[11]
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NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
PubMed=10233168 [NCBI, ExPASy, EBI, Israel, Japan]
Nishioka K.,
Ohtsubo T.,
Oda H.,
Fujiwara T.,
Kang D.,
Sugimachi K.,
Nakabeppu Y.;
"Expression and differential intracellular localization of two major forms of human 8-Oxoguanine DNA glycosylase encoded by alternatively spliced OGG1 mRNAs.";
Mol. Biol. Cell 10:1637-1652(1999).
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[12]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1A), AND VARIANT CYS-326.
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T.,
Suzuki Y.,
Nishikawa T.,
Otsuki T.,
Sugiyama T.,
Irie R.,
Wakamatsu A.,
Hayashi K.,
Sato H.,
Nagai K.,
Kimura K.,
Makita H.,
Sekine M.,
Obayashi M.,
Nishi T.,
Shibahara T.,
Tanaka T.,
Ishii S.,
Yamamoto J., ![]()
Saito K.,
Kawai Y.,
Isono Y.,
Nakamura Y.,
Nagahari K.,
Murakami K.,
Yasuda T.,
Iwayanagi T.,
Wagatsuma M.,
Shiratori A.,
Sudo H.,
Hosoiri T.,
Kaku Y.,
Kodaira H.,
Kondo H.,
Sugawara M.,
Takahashi M.,
Kanda K.,
Yokoi T.,
Furuya T.,
Kikkawa E.,
Omura Y.,
Abe K.,
Kamihara K.,
Katsuta N.,
Sato K.,
Tanikawa M.,
Yamazaki M.,
Ninomiya K.,
Ishibashi T.,
Yamashita H.,
Murakawa K.,
Fujimori K.,
Tanai H.,
Kimata M.,
Watanabe M.,
Hiraoka S.,
Chiba Y.,
Ishida S.,
Ono Y.,
Takiguchi S.,
Watanabe S.,
Yosida M.,
Hotuta T.,
Kusano J.,
Kanehori K.,
Takahashi-Fujii A.,
Hara H.,
Tanase T.-O.,
Nomura Y.,
Togiya S.,
Komai F.,
Hara R.,
Takeuchi K.,
Arita M.,
Imose N.,
Musashino K.,
Yuuki H.,
Oshima A.,
Sasaki N.,
Aotsuka S.,
Yoshikawa Y.,
Matsunawa H.,
Ichihara T.,
Shiohata N.,
Sano S.,
Moriya S.,
Momiyama H.,
Satoh N.,
Takami S.,
Terashima Y.,
Suzuki O.,
Nakagawa S.,
Senoh A.,
Mizoguchi H.,
Goto Y.,
Shimizu F.,
Wakebe H.,
Hishigaki H.,
Watanabe T.,
Sugiyama A.,
Takemoto M.,
Kawakami B.,
Yamazaki M.,
Watanabe K.,
Kumagai A.,
Itakura S.,
Fukuzumi Y.,
Fujimori Y.,
Komiyama M.,
Tashiro H.,
Tanigami A.,
Fujiwara T.,
Ono T.,
Yamada K.,
Fujii Y.,
Ozaki K.,
Hirao M.,
Ohmori Y.,
Kawabata A.,
Hikiji T.,
Kobatake N.,
Inagaki H.,
Ikema Y.,
Okamoto S.,
Okitani R.,
Kawakami T.,
Noguchi S.,
Itoh T.,
Shigeta K.,
Senba T.,
Matsumura K.,
Nakajima Y.,
Mizuno T.,
Morinaga M.,
Sasaki M.,
Togashi T.,
Oyama M.,
Hata H.,
Watanabe M.,
Komatsu T.,
Mizushima-Sugano J.,
Satoh T.,
Shirai Y.,
Takahashi Y.,
Nakagawa K.,
Okumura K.,
Nagase T.,
Nomura N.,
Kikuchi H.,
Masuho Y.,
Yamashita R.,
Nakai K.,
Yada T.,
Nakamura Y.,
Ohara O.,
Isogai T.,
Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
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[13]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-229; VAL-288; ASN-322 AND CYS-326.
NIEHS SNPs program;
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
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[14]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04728; PubMed=16641997 [NCBI, ExPASy, EBI, Israel, Japan]
Muzny D.M.,
Scherer S.E.,
Kaul R.,
Wang J.,
Yu J.,
Sudbrak R.,
Buhay C.J.,
Chen R.,
Cree A.,
Ding Y.,
Dugan-Rocha S.,
Gill R.,
Gunaratne P.,
Harris R.A.,
Hawes A.C.,
Hernandez J.,
Hodgson A.V.,
Hume J.,
Jackson A., ![]()
Khan Z.M.,
Kovar-Smith C.,
Lewis L.R.,
Lozado R.J.,
Metzker M.L.,
Milosavljevic A.,
Miner G.R.,
Morgan M.B.,
Nazareth L.V.,
Scott G.,
Sodergren E.,
Song X.-Z.,
Steffen D.,
Wei S.,
Wheeler D.A.,
Wright M.W.,
Worley K.C.,
Yuan Y.,
Zhang Z.,
Adams C.Q.,
Ansari-Lari M.A.,
Ayele M.,
Brown M.J.,
Chen G.,
Chen Z.,
Clendenning J.,
Clerc-Blankenburg K.P.,
Chen R.,
Chen Z.,
Davis C.,
Delgado O.,
Dinh H.H.,
Dong W.,
Draper H.,
Ernst S.,
Fu G.,
Gonzalez-Garay M.L.,
Garcia D.K.,
Gillett W.,
Gu J.,
Hao B.,
Haugen E.,
Havlak P.,
He X.,
Hennig S.,
Hu S.,
Huang W.,
Jackson L.R.,
Jacob L.S.,
Kelly S.H.,
Kube M.,
Levy R.,
Li Z.,
Liu B.,
Liu J.,
Liu W.,
Lu J.,
Maheshwari M.,
Nguyen B.-V.,
Okwuonu G.O.,
Palmeiri A.,
Pasternak S.,
Perez L.M.,
Phelps K.A.,
Plopper F.J.,
Qiang B.,
Raymond C.,
Rodriguez R.,
Saenphimmachak C.,
Santibanez J.,
Shen H.,
Shen Y.,
Subramanian S.,
Tabor P.E.,
Verduzco D.,
Waldron L.,
Wang J.,
Wang J.,
Wang Q.,
Williams G.A.,
Wong G.K.-S.,
Yao Z.,
Zhang J.,
Zhang X.,
Zhao G.,
Zhou J.,
Zhou Y.,
Nelson D.,
Lehrach H.,
Reinhardt R.,
Naylor S.L.,
Yang H.,
Olson M.,
Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
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[15]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-326.
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[16]
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REVIEW.
DOI=10.1006/abbi.2000.1773; PubMed=10775435 [NCBI, ExPASy, EBI, Israel, Japan]
Boiteux S.,
Radicella J.P.;
"The human OGG1 gene: structure, functions, and its implication in the process of carcinogenesis.";
Arch. Biochem. Biophys. 377:1-8(2000).
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[17]
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X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 12-327 OF MUTANT GLN-247 IN COMPLEX WITH DNA, AND CHARACTERIZATION OF VARIANT HIS-154.
DOI=10.1038/35002510; PubMed=10706276 [NCBI, ExPASy, EBI, Israel, Japan]
Bruner S.D.,
Norman D.P.G.,
Verdine G.L.;
"Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA.";
Nature 403:859-866(2000).
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[18]
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X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH DNA AND 8-OXO-GUANINE.
DOI=10.1006/jmbi.2002.5400; PubMed=11902834 [NCBI, ExPASy, EBI, Israel, Japan]
Bjoras M.,
Seeberg E.,
Luna L.,
Pearl L.H.,
Barrett T.E.;
"Reciprocal 'flipping'; underlies substrate recognition and catalytic activation by the human 8-oxo-guanine DNA glycosylase.";
J. Mol. Biol. 317:171-177(2002).
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[19]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 12-327 OF MUTANTS ASN-268; GLU-268 AND GLN-268 IN COMPLEX WITH DNA, AND MUTAGENESIS OF ASP-268.
DOI=10.1021/bi026823d; PubMed=12578369 [NCBI, ExPASy, EBI, Israel, Japan]
Norman D.P.G.,
Chung S.J.,
Verdine G.L.;
"Structural and biochemical exploration of a critical amino acid in human 8-oxoguanine glycosylase.";
Biochemistry 42:1564-1572(2003).
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[20]
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X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 12-327 IN COMPLEX WITH DNA AND 8-OXO-GUANINE.
DOI=10.1038/nsb902; PubMed=12592398 [NCBI, ExPASy, EBI, Israel, Japan]
Fromme J.C.,
Bruner S.D.,
Yang W.,
Karplus M.,
Verdine G.L.;
"Product-assisted catalysis in base-excision DNA repair.";
Nat. Struct. Biol. 10:204-211(2003).
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[21]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 12-325 OF MUTANT GLU-268 IN COMPLEX WITH DNA.
DOI=10.1016/j.chembiol.2004.09.014; PubMed=15610848 [NCBI, ExPASy, EBI, Israel, Japan]
Chung S.J.,
Verdine G.L.;
"Structures of end products resulting from lesion processing by a DNA glycosylase/lyase.";
Chem. Biol. 11:1643-1649(2004).
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[22]
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X-RAY CRYSTALLOGRAPHY (2.57 ANGSTROMS) OF 12-327 OF MUTANTS ALA-42/ALA-270/ALA-315/PHE-315 IN COMPLEXES WITH DNA.
DOI=10.1074/jbc.M608989200; PubMed=17114185 [NCBI, ExPASy, EBI, Israel, Japan]
Radom C.T.,
Banerjee A.,
Verdine G.L.;
"Structural characterization of human 8-oxoguanine DNA glycosylase variants bearing active site mutations.";
J. Biol. Chem. 282:9182-9194(2007).
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[23]
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VARIANT HIS-154.
PubMed=9765618 [NCBI, ExPASy, EBI, Israel, Japan]
Shinmura K.,
Kohno T.,
Kasai H.,
Koda K.,
Sugimura H.,
Yokota J.;
"Infrequent mutations of the hOGG1 gene, that is involved in the excision of 8-hydroxyguanine in damaged DNA, in human gastric cancer.";
Jpn. J. Cancer Res. 89:825-828(1998).
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[24]
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VARIANTS SER-85; GLN-131 AND THR-232, AND CHARACTERIZATION OF VARIANT GLN-131.
DOI=10.1038/sj.onc.1202096; PubMed=9662341 [NCBI, ExPASy, EBI, Israel, Japan]
Chevillard S.,
Radicella J.P.,
Levalois C.,
Lebeau J.,
Poupon M.-F.,
Oudard S.,
Dutrillaux B.,
Boiteux S.;
"Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours.";
Oncogene 16:3083-3086(1998).
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[25]
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CHARACTERIZATION OF VARIANT CYS-326.
DOI=10.1093/nar/27.20.4001; PubMed=10497264 [NCBI, ExPASy, EBI, Israel, Japan]
Dherin C.,
Radicella J.P.,
Dizdaroglu M.,
Boiteux S.;
"Excision of oxidatively damaged DNA bases by the human alpha-hOgg1 protein and the polymorphic alpha-hOgg1(Ser326Cys) protein which is frequently found in human populations.";
Nucleic Acids Res. 27:4001-4007(1999).
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[26]
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CHARACTERIZATION OF VARIANTS GLN-46 AND HIS-154.
DOI=10.1093/nar/28.14.2672; PubMed=10908322 [NCBI, ExPASy, EBI, Israel, Japan]
Audebert M.,
Radicella J.P.,
Dizdaroglu M.;
"Effect of single mutations in the OGG1 gene found in human tumors on the substrate specificity of the ogg1 protein.";
Nucleic Acids Res. 28:2672-2678(2000).
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[27]
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CHARACTERIZATION OF VARIANT GLU-12.
DOI=10.1016/S1568-7864(02)00034-4; PubMed=12509224 [NCBI, ExPASy, EBI, Israel, Japan]
Audebert M.,
Charbonnier J.-B.,
Boiteux S.,
Radicella J.P.;
"Mitochondrial targeting of human 8-oxoguanine DNA glycosylase hOGG1 is impaired by a somatic mutation found in kidney cancer.";
DNA Repair 1:497-505(2002).
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