[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1016/S0092-8674(00)80324-4; PubMed=9230313 [NCBI, ExPASy, EBI, Israel, Japan]
Zeng L.,
Fagotto F.,
Zhang T.,
Hsu W.,
Vasicek T.J.,
Perry W.L. III,
Lee J.J.,
Tilghman S.M.,
Gumbiner B.M.,
Costantini F.;
"The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.";
Cell 90:181-192(1997).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1093/hmg/10.4.339; PubMed=11157797 [NCBI, ExPASy, EBI, Israel, Japan]
Daniels R.J.,
Peden J.F.,
Lloyd C.,
Horsley S.W.,
Clark K.,
Tufarelli C.,
Kearney L.,
Buckle V.J.,
Doggett N.A.,
Flint J.,
Higgs D.R.;
"Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.";
Hum. Mol. Genet. 10:339-352(2001).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03187; PubMed=15616553 [NCBI, ExPASy, EBI, Israel, Japan]
Martin J.,
Han C.,
Gordon L.A.,
Terry A.,
Prabhakar S.,
She X.,
Xie G.,
Hellsten U.,
Chan Y.M.,
Altherr M.,
Couronne O.,
Aerts A.,
Bajorek E.,
Black S.,
Blumer H.,
Branscomb E.,
Brown N.C.,
Bruno W.J.,
Buckingham J.M., ![]()
Callen D.F.,
Campbell C.S.,
Campbell M.L.,
Campbell E.W.,
Caoile C.,
Challacombe J.F.,
Chasteen L.A.,
Chertkov O.,
Chi H.C.,
Christensen M.,
Clark L.M.,
Cohn J.D.,
Denys M.,
Detter J.C.,
Dickson M.,
Dimitrijevic-Bussod M.,
Escobar J.,
Fawcett J.J.,
Flowers D.,
Fotopulos D.,
Glavina T.,
Gomez M.,
Gonzales E.,
Goodstein D.,
Goodwin L.A.,
Grady D.L.,
Grigoriev I.,
Groza M.,
Hammon N.,
Hawkins T.,
Haydu L.,
Hildebrand C.E.,
Huang W.,
Israni S.,
Jett J.,
Jewett P.B.,
Kadner K.,
Kimball H.,
Kobayashi A.,
Krawczyk M.-C.,
Leyba T.,
Longmire J.L.,
Lopez F.,
Lou Y.,
Lowry S.,
Ludeman T.,
Manohar C.F.,
Mark G.A.,
McMurray K.L.,
Meincke L.J.,
Morgan J.,
Moyzis R.K.,
Mundt M.O.,
Munk A.C.,
Nandkeshwar R.D.,
Pitluck S.,
Pollard M.,
Predki P.,
Parson-Quintana B.,
Ramirez L.,
Rash S.,
Retterer J.,
Ricke D.O.,
Robinson D.L.,
Rodriguez A.,
Salamov A.,
Saunders E.H.,
Scott D.,
Shough T.,
Stallings R.L.,
Stalvey M.,
Sutherland R.D.,
Tapia R.,
Tesmer J.G.,
Thayer N.,
Thompson L.S.,
Tice H.,
Torney D.C.,
Tran-Gyamfi M.,
Tsai M.,
Ulanovsky L.E.,
Ustaszewska A.,
Vo N.,
White P.S.,
Williams A.L.,
Wills P.L.,
Wu J.-R.,
Wu K.,
Yang J.,
DeJong P.,
Bruce D.,
Doggett N.A.,
Deaven L.,
Schmutz J.,
Grimwood J.,
Richardson P.,
Rokhsar D.S.,
Eichler E.E.,
Gilna P.,
Lucas S.M.,
Myers R.M.,
Rubin E.M.,
Pennacchio L.A.;
"The sequence and analysis of duplication-rich human chromosome 16.";
Nature 432:988-994(2004).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 471-862 (ISOFORM 1).
TISSUE=Lymphoma, and Renal cell carcinoma;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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INTERACTION WITH MDFI AND MDFIC.
DOI=10.1128/MCB.22.18.6393-6405.2002; PubMed=12192039 [NCBI, ExPASy, EBI, Israel, Japan]
Kusano S.,
Raab-Traub N.;
"I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways.";
Mol. Cell. Biol. 22:6393-6405(2002).
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[6]
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INTERACTION WITH DIXDC1; MAP3K1 AND MAP3K4.
DOI=10.1074/jbc.M404598200; PubMed=15262978 [NCBI, ExPASy, EBI, Israel, Japan]
Wong C.K.,
Luo W.,
Deng Y.,
Zou H.,
Ye Z.,
Lin S.-C.;
"The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.";
J. Biol. Chem. 279:39366-39373(2004).
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[7]
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INTERACTION WITH SMAD6; SMAD7 AND RNF111, FUNCTION, AND SUBCELLULAR LOCATION.
DOI=10.1038/sj.emboj.7601057; PubMed=16601693 [NCBI, ExPASy, EBI, Israel, Japan]
Liu W.,
Rui H.,
Wang J.,
Lin S.,
He Y.,
Chen M.,
Li Q.,
Ye Z.,
Zhang S.,
Chan S.C.,
Chen Y.-G.,
Han J.,
Lin S.-C.;
"Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia.";
EMBO J. 25:1646-1658(2006).
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[8]
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X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 80-211 IN COMPLEX WITH APC.
DOI=10.1093/emboj/19.10.2270; PubMed=10811618 [NCBI, ExPASy, EBI, Israel, Japan]
Spink K.E.,
Polakis P.,
Weis W.I.;
"Structural basis of the axin-adenomatous polyposis coli interaction.";
EMBO J. 19:2270-2279(2000).
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[9]
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DISEASE.
DOI=10.1038/73448; PubMed=10700176 [NCBI, ExPASy, EBI, Israel, Japan]
Satoh S.,
Daigo Y.,
Furukawa Y.,
Kato T.,
Miwa N.,
Nishiwaki T.,
Kawasoe T.,
Ishiguro H.,
Fujita M.,
Tokino T.,
Sasaki Y.,
Imaoka S.,
Murata M.,
Shimano T.,
Yamaoka Y.,
Nakamura Y.;
"AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.";
Nat. Genet. 24:245-250(2000).
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[10]
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VARIANTS HCC ARG-106; LEU-345; SER-425 AND SER-650, AND VARIANT HEPATOBLASTOMA GLN-841.
DOI=10.1038/sj.onc.1205591; PubMed=12101426 [NCBI, ExPASy, EBI, Israel, Japan]
Taniguchi K.,
Roberts L.R.,
Aderca I.N.,
Dong X.,
Qian C.,
Murphy L.M.,
Nagorney D.M.,
Burgart L.J.,
Roche P.C.,
Smith D.I.,
Ross J.A.,
Liu W.;
"Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas.";
Oncogene 21:4863-4871(2002).
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[11]
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INVOLVEMENT IN CAUDAL DUPLICATION ANOMALY.
DOI=10.1086/505031; PubMed=16773576 [NCBI, ExPASy, EBI, Israel, Japan]
Oates N.A.,
van Vliet J.,
Duffy D.L.,
Kroes H.Y.,
Martin N.G.,
Boomsma D.I.,
Campbell M.,
Coulthard M.G.,
Whitelaw E.,
Chong S.;
"Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.";
Am. J. Hum. Genet. 79:155-162(2006).
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