[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND MUTAGENESIS OF LYS-44.
TISSUE=T-cell;
DOI=10.1016/S0092-8674(00)80344-X; PubMed=9244310 [NCBI, ExPASy, EBI, Israel, Japan]
Regnier C.H.,
Song H.Y.,
Gao X.,
Goeddel D.V.,
Cao Z.,
Rothe M.;
"Identification and characterization of an IkappaB kinase.";
Cell 90:373-383(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
DOI=10.1038/41493; PubMed=9252186 [NCBI, ExPASy, EBI, Israel, Japan]
DiDonato J.A.,
Hayakawa M.,
Rothwarf D.M.,
Zandi E.,
Karin M.;
"A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.";
Nature 388:548-554(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, VARIANT VAL-268, AND MUTAGENESIS OF LYS-44 AND SER-176.
TISSUE=Cervix carcinoma;
DOI=10.1126/science.278.5339.860; PubMed=9346484 [NCBI, ExPASy, EBI, Israel, Japan]
Mercurio F.,
Zhu H.,
Murray B.W.,
Shevchenko A.,
Bennett B.L.,
Li J.W.,
Young D.B.,
Barbosa M.,
Mann M.,
Manning A.,
Rao A.;
"IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.";
Science 278:860-866(1997).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
DOI=10.1016/S0378-1119(98)00462-4; PubMed=9813230 [NCBI, ExPASy, EBI, Israel, Japan]
Hu M.C.-T.,
Wang Y.-P.;
"IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.";
Gene 222:31-40(1998).
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT VAL-268.
SeattleSNPs variation discovery resource;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-268.
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P.,
Earthrowl M.E.,
Grafham D.V.,
Rubenfield M.,
French L.,
Steward C.A.,
Sims S.K.,
Jones M.C.,
Searle S.,
Scott C.,
Howe K.,
Hunt S.E.,
Andrews T.D.,
Gilbert J.G.R.,
Swarbreck D.,
Ashurst J.L.,
Taylor A.,
Battles J.,
Bird C.P., ![]()
Ainscough R.,
Almeida J.P.,
Ashwell R.I.S.,
Ambrose K.D.,
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Banerjee R.,
Bates K.,
Beasley H.,
Bray-Allen S.,
Brown A.J.,
Brown J.Y.,
Burford D.C.,
Burrill W.,
Burton J.,
Cahill P.,
Camire D.,
Carter N.P.,
Chapman J.C.,
Clark S.Y.,
Clarke G.,
Clee C.M.,
Clegg S.,
Corby N.,
Coulson A.,
Dhami P.,
Dutta I.,
Dunn M.,
Faulkner L.,
Frankish A.,
Frankland J.A.,
Garner P.,
Garnett J.,
Gribble S.,
Griffiths C.,
Grocock R.,
Gustafson E.,
Hammond S.,
Harley J.L.,
Hart E.,
Heath P.D.,
Ho T.P.,
Hopkins B.,
Horne J.,
Howden P.J.,
Huckle E.,
Hynds C.,
Johnson C.,
Johnson D.,
Kana A.,
Kay M.,
Kimberley A.M.,
Kershaw J.K.,
Kokkinaki M.,
Laird G.K.,
Lawlor S.,
Lee H.M.,
Leongamornlert D.A.,
Laird G.,
Lloyd C.,
Lloyd D.M.,
Loveland J.,
Lovell J.,
McLaren S.,
McLay K.E.,
McMurray A.,
Mashreghi-Mohammadi M.,
Matthews L.,
Milne S.,
Nickerson T.,
Nguyen M.,
Overton-Larty E.,
Palmer S.A.,
Pearce A.V.,
Peck A.I.,
Pelan S.,
Phillimore B.,
Porter K.,
Rice C.M.,
Rogosin A.,
Ross M.T.,
Sarafidou T.,
Sehra H.K.,
Shownkeen R.,
Skuce C.D.,
Smith M.,
Standring L.,
Sycamore N.,
Tester J.,
Thorpe A.,
Torcasso W.,
Tracey A.,
Tromans A.,
Tsolas J.,
Wall M.,
Walsh J.,
Wang H.,
Weinstock K.,
West A.P.,
Willey D.L.,
Whitehead S.L.,
Wilming L.,
Wray P.W.,
Young L.,
Chen Y.,
Lovering R.C.,
Moschonas N.K.,
Siebert R.,
Fechtel K.,
Bentley D.,
Durbin R.M.,
Hubbard T.,
Doucette-Stamm L.,
Beck S.,
Smith D.R.,
Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
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[7]
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NUCLEOTIDE SEQUENCE [MRNA] OF 32-745.
TISSUE=Cervix carcinoma;
PubMed=8777433 [NCBI, ExPASy, EBI, Israel, Japan]
Connelly M.A.,
Marcu K.B.;
"CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain.";
Cell. Mol. Biol. Res. 41:537-549(1995).
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[8]
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IDENTIFICATION IN A COMPLEX WITH IKBKB; NFKBIA; RELA; IKBKAP AND MAP3K14.
DOI=10.1038/26254; PubMed=9751059 [NCBI, ExPASy, EBI, Israel, Japan]
Cohen L.,
Henzel W.J.,
Baeuerle P.A.;
"IKAP is a scaffold protein of the IkappaB kinase complex.";
Nature 395:292-296(1998).
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[9]
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PHOSPHORYLATION AT SER-176, AND MUTAGENESIS OF SER-176; THR-179 AND SER-180.
DOI=10.1073/pnas.95.7.3792; PubMed=9520446 [NCBI, ExPASy, EBI, Israel, Japan]
Ling L.,
Cao Z.,
Goeddel D.V.;
"NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.";
Proc. Natl. Acad. Sci. U.S.A. 95:3792-3797(1998).
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[10]
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PHOSPHORYLATION AT THR-23, AND MUTAGENESIS OF THR-23.
DOI=10.1038/43466; PubMed=10485710 [NCBI, ExPASy, EBI, Israel, Japan]
Ozes O.N.,
Mayo L.D.,
Gustin J.A.,
Pfeffer S.R.,
Pfeffer L.M.,
Donner D.B.;
"NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase.";
Nature 401:82-85(1999).
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[11]
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IKKA-IKKB BINDING.
DOI=10.1126/science.284.5412.309; PubMed=10195894 [NCBI, ExPASy, EBI, Israel, Japan]
Delhase M.,
Hayakawa M.,
Chen Y.,
Karin M.;
"Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.";
Science 284:309-313(1999).
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[12]
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IKK PHOSPHORYLATION.
PubMed=9819420 [NCBI, ExPASy, EBI, Israel, Japan]
Nemoto S.,
DiDonato J.A.,
Lin A.;
"Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase.";
Mol. Cell. Biol. 18:7336-7343(1998).
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[13]
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REVIEW.
PubMed=10712233 [NCBI, ExPASy, EBI, Israel, Japan]
Jobin C.,
Sartor R.B.;
"The I kappa B/NF-kappa B system: a key determinant of mucosal inflammation and protection.";
Am. J. Physiol. 278:C451-C462(2000).
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[14]
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SUBUNIT OF A COMPLEX CONTAINING CREBBP; NCOA2; NCOA3; IKKB AND IKBKG.
DOI=10.1128/MCB.22.10.3549-3561.2002; PubMed=11971985 [NCBI, ExPASy, EBI, Israel, Japan]
Wu R.-C.,
Qin J.,
Hashimoto Y.,
Wong J.,
Xu J.,
Tsai S.Y.,
Tsai M.-J.,
O'Malley B.W.;
"Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase.";
Mol. Cell. Biol. 22:3549-3561(2002).
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[15]
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COMPOSITION OF THE IKK COMPLEX.
DOI=10.1128/MCB.23.6.2029-2041.2003; PubMed=12612076 [NCBI, ExPASy, EBI, Israel, Japan]
Tegethoff S.,
Behlke J.,
Scheidereit C.;
"Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.";
Mol. Cell. Biol. 23:2029-2041(2003).
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[16]
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SUBCELLULAR LOCATION, AND FUNCTION IN PHOSPHORYLATION OF HISTONE H3.
DOI=10.1038/nature01576; PubMed=12789342 [NCBI, ExPASy, EBI, Israel, Japan]
Yamamoto Y.,
Verma U.N.,
Prajapati S.,
Kwak Y.T.,
Gaynor R.B.;
"Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.";
Nature 423:655-659(2003).
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[17]
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INTERACTION WITH NALP2.
DOI=10.1074/jbc.M406741200; PubMed=15456791 [NCBI, ExPASy, EBI, Israel, Japan]
Bruey J.-M.,
Bruey-Sedano N.,
Newman R.,
Chandler S.,
Stehlik C.,
Reed J.C.;
"PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages.";
J. Biol. Chem. 279:51897-51907(2004).
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[18]
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INTERACTION WITH MAVS.
DOI=10.1038/nature04193; PubMed=16177806 [NCBI, ExPASy, EBI, Israel, Japan]
Meylan E.,
Curran J.,
Hofmann K.,
Moradpour D.,
Binder M.,
Bartenschlager R.,
Tschopp J.;
"Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.";
Nature 437:1167-1172(2005).
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[19]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[20]
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VARIANTS [LARGE SCALE ANALYSIS] CYS-126; ALA-155 AND VAL-268.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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