[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH ATF4, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INVOLVEMENT IN JBTS5 AND SLSN6. DOI=10.1038/ng1786; PubMed=16682973 [NCBI, ExPASy, EBI, Israel, Japan] Sayer J.A., Otto E.A., O'toole J.F., Nurnberg G., Kennedy M.A., Becker C., Hennies H.C., Helou J., Attanasio M., Fausett B.V., Utsch B., Khanna H., Liu Y., Drummond I., Kawakami I., Kusakabe T., Tsuda M., Ma L., Lee H., Larson R.G., Allen S.J., Wilkinson C.J., Nigg E.A., Shou C., Lillo C., Williams D.S., Hoppe B., Kemper M.J., Neuhaus T., Parisi M.A., Glass I.A., Petry M., Kispert A., Gloy J., Ganner A., Walz G., Zhu X., Goldman D., Nurnberg P., Swaroop A., Leroux M.R., Hildebrandt F.; "The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4."; Nat. Genet. 38:674-681(2006).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). TISSUE=Brain; DOI=10.1093/dnares/4.2.141; PubMed=9205841 [NCBI, ExPASy, EBI, Israel, Japan] Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.; "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."; DNA Res. 4:141-150(1997).
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1038/nature04569; PubMed=16541075 [NCBI, ExPASy, EBI, Israel, Japan] Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.; "The finished DNA sequence of human chromosome 12."; Nature 440:346-351(2006).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1058 (ISOFORM 1). TISSUE=Hepatoma, and Placenta; DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan] Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; "Complete sequencing and characterization of 21,243 full-length human cDNAs."; Nat. Genet. 36:40-45(2004).
[5]	NUCLEOTIDE SEQUENCE [MRNA] OF 1616-2382, TISSUE SPECIFICITY, AND DISEASE. TISSUE=Testis; DOI=10.1073/pnas.021386498; PubMed=11149944 [NCBI, ExPASy, EBI, Israel, Japan] Eichmueller S., Usener D., Dummer R., Stein A., Thiel D., Schadendorf D.; "Serological detection of cutaneous T-cell lymphoma-associated antigens."; Proc. Natl. Acad. Sci. U.S.A. 98:629-634(2001).
[6]	IDENTIFICATION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. DOI=10.1038/nature02166; PubMed=14654843 [NCBI, ExPASy, EBI, Israel, Japan] Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.; "Proteomic characterization of the human centrosome by protein correlation profiling."; Nature 426:570-574(2003).
[7]	INVOLVEMENT IN LCA10. DOI=10.1086/507318; PubMed=16909394 [NCBI, ExPASy, EBI, Israel, Japan] den Hollander A.I., Koenekoop R.K., Yzer S., Lopez I., Arends M.L., Voesenek K.E.J., Zonneveld M.N., Strom T.M., Meitinger T., Brunner H.G., Hoyng C.B., van den Born L.I., Rohrschneider K., Cremers F.P.M.; "Mutations in the CEP290 (NPHP6) gene are a frequent cause of Leber congenital amaurosis."; Am. J. Hum. Genet. 79:556-561(2006).
[8]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1697, AND MASS SPECTROMETRY. TISSUE=Epithelium; DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan] Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.; "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."; Cell 127:635-648(2006).
[9]	INTERACTION WITH CC2D2A. DOI=10.1016/j.ajhg.2008.10.002; PubMed=18950740 [NCBI, ExPASy, EBI, Israel, Japan] Gorden N.T., Arts H.H., Parisi M.A., Coene K.L.M., Letteboer S.J.F., van Beersum S.E.C., Mans D.A., Hikida A., Eckert M., Knutzen D., Alswaid A.F., Oezyurek H., Dibooglu S., Otto E.A., Liu Y., Davis E.E., Hutter C.M., Bammler T.K., Farin F.M., Dorschner M., Topcu M., Zackai E.H., Rosenthal P., Owens K.N., Katsanis N., Vincent J.B., Hildebrandt F., Rubel E.W., Raible D.W., Knoers N.V.A.M., Chance P.F., Roepman R., Moens C.B., Glass I.A., Doherty D.; "CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290."; Am. J. Hum. Genet. 83:559-571(2008).
[10]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1209, AND MASS SPECTROMETRY. DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan] Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Anal. Sci. 24:161-166(2008).
[11]	VARIANT JBTS5 CYS-7. DOI=10.1038/ng1805; PubMed=16682970 [NCBI, ExPASy, EBI, Israel, Japan] International Joubert syndrome related disorders (JSRD) study group; Valente E.M., Silhavy J.L., Brancati F., Barrano G., Krishnaswami S.R., Castori M., Lancaster M.A., Boltshauser E., Boccone L., Al-Gazali L., Fazzi E., Signorini S., Louie C.M., Bellacchio E., Bertini E., Dallapiccola B., Gleeson J.G.; "Mutations in CEP290, which encodes a centrosomal protein, cause pleiotropic forms of Joubert syndrome."; Nat. Genet. 38:623-625(2006).
[12]	INVOLVEMENT IN MKS4. DOI=10.1086/519494; PubMed=17564974 [NCBI, ExPASy, EBI, Israel, Japan] Baala L., Audollent S., Martinovic J., Ozilou C., Babron M.-C., Sivanandamoorthy S., Saunier S., Salomon R., Gonzales M., Rattenberry E., Esculpavit C., Toutain A., Moraine C., Parent P., Marcorelles P., Dauge M.-C., Roume J., Le Merrer M., Meiner V., Meir K., Menez F., Beaufrere A.-M., Francannet C., Tantau J., Sinico M., Dumez Y., MacDonald F., Munnich A., Lyonnet S., Gubler M.-C., Genin E., Johnson C.A., Vekemans M., Encha-Razavi F., Attie-Bitach T.; "Pleiotropic effects of CEP290 (NPHP6) mutations extend to Meckel syndrome."; Am. J. Hum. Genet. 81:170-179(2007).

Comments

FUNCTION: Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes.
SUBUNIT: Interacts with ATF4 via its N-terminal region. Part of selected centrosomal and microtubule-associated protein complexes. Interacts with CC2D2A.
SUBCELLULAR LOCATION: Centrosome. Nucleus. Cell projection, cilium. Note=Connecting cilium of photoreceptor cells, base of cilium in kidney intramedullary collecting duct cells.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	O15078-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	O15078-2
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_021027.

TISSUE SPECIFICITY: Ubiquitous. Expressed strongly in placenta and weakly in brain.
DISEASE: Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188]. Joubert syndrome is an autosomal recessive disease characterized by cerebellar vermis hypoplasia with prominent superior cerebellar peduncles (the 'molar tooth sign' on axial magnetic resonance imaging), psychomotor delay, hypotonia, ataxia, oculomotor apraxia and neonatal breathing abnormalities. JBTS5 shares the neurologic and neuroradiologic features of Joubert syndrome together with severe retinal dystrophy and/or progressive renal failure characterized by nephronophthisis.
DISEASE: Defects in CEP290 are a cause of Senior-Loken syndrome type 6 (SLSN6) [MIM:610189]. Senior-Loken syndrome is also known as juvenile nephronophthisis with Leber amaurosis. It is an autosomal recessive renal-retinal disorder, characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease.
DISEASE: Defects in CEP290 are the cause of Leber congenital amaurosis type 10 (LCA10) [MIM:611755]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
DISEASE: Defects in CEP290 are the cause of Meckel syndrome type 4 (MKS4) [MIM:611134]. MKS4 is an autosomal recessive disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly.
DISEASE: Antibodies against CEP290 are present in sera from patients with cutaneous T-cell lymphomas, but not in the healthy control population.
SEQUENCE CAUTION:
- Sequence=AAG34904.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
- Sequence=AK023677; Type=Frameshift; Positions=556;
- Sequence=BAB15196.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence
WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=CEP290";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ109808; AAZ83370.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AB002371; BAA20828.2; ALT_INIT; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AC091516; -; NOT_ANNOTATED_CDS; Genomic_DNA.	[EMBL / GenBank / DDBJ]
AK023677; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]
AK025632; BAB15196.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF273044; AAG34904.1; ALT_SEQ; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BK005587; DAA05591.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00784201; -.
IPI00794668; -.

RefSeq

NP_079390.3; -.

UniGene

Hs.150444

3D structure databases

HSSP

Q9WUW2; 1SFC. [HSSP ENTRY / PDB]

ModBase

O15078.

Protein-protein interaction databases

IntAct

O15078; 2.

PTM databases

PhosphoSite

O15078; -.

Organism-specific databases

GeneCards

GC12M086966; -.

H-InvDB

HIX0010863; -.
HIX0010864; -.
HIX0037052; -.

HGNC:29021; CEP290.

610142; gene. [NCBI / EBI]
610188; phenotype. [NCBI / EBI]
610189; phenotype. [NCBI / EBI]
611134; phenotype. [NCBI / EBI]
611755; phenotype. [NCBI / EBI]

Orphanet

475; Joubert syndrome.
65; Leber amaurosis, congenital.
564; Meckel syndrome.
3156; Senior-Loken syndrome.

HUGE

KIAA0373.

Gene expression databases

O15078; -.

O15078; -.

HS_CEP290; -.

ENSG00000198707; Homo sapiens.

Ontologies

GO:0009986;	Cellular component: cell surface (inferred from direct assay from UniProtKB).
GO:0005813;	Cellular component: centrosome (inferred from direct assay from UniProtKB).
GO:0005829;	Cellular component: cytosol (inferred from direct assay from HGNC).
GO:0005634;	Cellular component: nucleus (inferred from direct assay from HGNC).
GO:0032391;	Cellular component: photoreceptor connecting cilium (inferred from sequence or structural similarity from UniProtKB).
GO:0005515;	Molecular function: protein binding (inferred from physical interaction from HGNC).
GO:0016563;	Molecular function: transcription activator activity (inferred from direct assay from HGNC).
GO:0030030;	Biological process: cell projection organization (inferred from electronic annotation from UniProtKB-KW).
GO:0042462;	Biological process: eye photoreceptor cell development (inferred from sequence or structural similarity from HGNC).
GO:0030902;	Biological process: hindbrain development (inferred from sequence or structural similarity from HGNC).
GO:0030916;	Biological process: otic vesicle formation (inferred from sequence or structural similarity from HGNC).
GO:0048793;	Biological process: pronephros development (inferred from sequence or structural similarity from HGNC).
GO:0015031;	Biological process: protein transport (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Genome annotation databases

Ensembl

ENSG00000198707; Homo sapiens. [Contig view]

GeneID

80184; -.

KEGG

hsa:80184; -.

Phylogenomic databases

HOGENOM

O15078; -.

HOVERGEN

O15078; -.

Other

NextBio

70527; -.

SOURCE

CEP290; Homo sapiens.

ProtoNet

O15078.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Activator; Alternative splicing; Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil; Disease mutation; Joubert syndrome; Leber congenital amaurosis; Meckel syndrome; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Senior-Loken syndrome; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 2479`	`2479`	`Centrosomal protein of 290 kDa.`	`PRO_0000089464`
`COILED`	`59 565`	`507`	`Potential.`
`COILED`	`598 664`	`67`	`Potential.`
`COILED`	`697 931`	`235`	`Potential.`
`COILED`	`958 1027`	`70`	`Potential.`
`COILED`	`1071 1498`	`428`	`Potential.`
`COILED`	`1533 1584`	`52`	`Potential.`
`COILED`	`1635 2452`	`818`	`Potential.`
`MOD_RES`	`1209 1209`		`Phosphoserine.`
`MOD_RES`	`1697 1697`		`Phosphoserine.`
`VAR_SEQ`	`1 940`		`Missing (in isoform 2).`	`VSP_021027`
`VARIANT`	`7 7`	`1`	`W -> C (in JBTS5).`	`VAR_028356`
`VARIANT`	`838 838`	`1`	`K -> E (in dbSNP:rs11104738 [NCBI]).`	`VAR_031058`
`VARIANT`	`906 906`	`1`	`L -> W (in dbSNP:rs7970228 [NCBI]).`	`VAR_031059`
`VARIANT`	`1237 1237`	`1`	`R -> H (in dbSNP:rs7307793 [NCBI]).`	`VAR_031060`
`VARIANT`	`1836 1836`	`1`	`I -> V (in dbSNP:rs11104729 [NCBI]).`	`VAR_031061`
`CONFLICT`	`544 544`		`S -> C (in Ref. 4; AK023677).`
`CONFLICT`	`718 718`		`E -> G (in Ref. 4; AK023677).`

Sequence information

Length: 2479 AA [This is the length of the unprocessed precursor]

Molecular weight: 290386 Da [This is the MW of the unprocessed precursor]

CRC64: 7CA87D53FAF036FC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPPNINWKEI MKVDPDDLPR QEELADNLLI SLSKVEVNEL KSEKQENVIH LFRITQSLMK 

        70         80         90        100        110        120 
MKAQEVELAL EEVEKAGEEQ AKFENQLKTK VMKLENELEM AQQSAGGRDT RFLRNEICQL 

       130        140        150        160        170        180 
EKQLEQKDRE LEDMEKELEK EKKVNEQLAL RNEEAENENS KLRRENKRLK KKNEQLCQDI 

       190        200        210        220        230        240 
IDYQKQIDSQ KETLLSRRGE DSDYRSQLSK KNYELIQYLD EIQTLTEANE KIEVQNQEMR 

       250        260        270        280        290        300 
KNLEESVQEM EKMTDEYNRM KAIVHQTDNV IDQLKKENDH YQLQVQELTD LLKSKNEEDD 

       310        320        330        340        350        360 
PIMVAVNAKV EEWKLILSSK DDEIIEYQQM LHNLREKLKN AQLDADKSNV MALQQGIQER 

       370        380        390        400        410        420 
DSQIKMLTEQ VEQYTKEMEK NTCIIEDLKN ELQRNKGAST LSQQTHMKIQ STLDILKEKT 

       430        440        450        460        470        480 
KEAERTAELA EADAREKDKE LVEALKRLKD YESGVYGLED AVVEIKNCKN QIKIRDREIE 

       490        500        510        520        530        540 
ILTKEINKLE LKISDFLDEN EALRERVGLE PKTMIDLTEF RNSKHLKQQQ YRAENQILLK 

       550        560        570        580        590        600 
EIESLEEERL DLKKKIRQMA QERGKRSATS GLTTEDLNLT ENISQGDRIS ERKLDLLSLK 

       610        620        630        640        650        660 
NMSEAQSKNE FLSRELIEKE RDLERSRTVI AKFQNKLKEL VEENKQLEEG MKEILQAIKE 

       670        680        690        700        710        720 
MQKDPDVKGG ETSLIIPSLE RLVNAIESKN AEGIFDASLH LKAQVDQLTG RNEELRQELR 

       730        740        750        760        770        780 
ESRKEAINYS QQLAKANLKI DHLEKETSLL RQSEGSNVVF KGIDLPDGIA PSSASIINSQ 

       790        800        810        820        830        840 
NEYLIHLLQE LENKEKKLKN LEDSLEDYNR KFAVIRHQQS LLYKEYLSEK ETWKTESKTI 

       850        860        870        880        890        900 
KEEKRKLEDQ VQQDAIKVKE YNNLLNALQM DSDEMKKILA ENSRKITVLQ VNEKSLIRQY 

       910        920        930        940        950        960 
TTLVELERQL RKENEKQKNE LLSMEAEVCE KIGCLQRFKE MAIFKIAALQ KVVDNSVSLS 

       970        980        990       1000       1010       1020 
ELELANKQYN ELTAKYRDIL QKDNMLVQRT SNLEHLECEN ISLKEQVESI NKELEITKEK 

      1030       1040       1050       1060       1070       1080 
LHTIEQAWEQ ETKLGNESSM DKAKKSITNS DIVSISKKIT MLEMKELNER QRAEHCQKMY 

      1090       1100       1110       1120       1130       1140 
EHLRTSLKQM EERNFELETK FAELTKINLD AQKVEQMLRD ELADSVSKAV SDADRQRILE 

      1150       1160       1170       1180       1190       1200 
LEKNEMELKV EVSKLREISD IARRQVEILN AQQQSRDKEV ESLRMQLLDY QAQSDEKSLI 

      1210       1220       1230       1240       1250       1260 
AKLHQHNVSL QLSEATALGK LESITSKLQK MEAYNLRLEQ KLDEKEQALY YARLEGRNRA 

      1270       1280       1290       1300       1310       1320 
KHLRQTIQSL RRQFSGALPL AQQEKFSKTM IQLQNDKLKI MQEMKNSQQE HRNMENKTLE 

      1330       1340       1350       1360       1370       1380 
MELKLKGLEE LISTLKDTKG AQKVINWHMK IEELRLQELK LNRELVKDKE EIKYLNNIIS 

      1390       1400       1410       1420       1430       1440 
EYERTISSLE EEIVQQNKFH EERQMAWDQR EVDLERQLDI FDRQQNEILN AAQKFEEATG 

      1450       1460       1470       1480       1490       1500 
SIPDPSLPLP NQLEIALRKI KENIRIILET RATCKSLEEK LKEKESALRL AEQNILSRDK 

      1510       1520       1530       1540       1550       1560 
VINELRLRLP ATAEREKLIA ELGRKEMEPK SHHTLKIAHQ TIANMQARLN QKEEVLKKYQ 

      1570       1580       1590       1600       1610       1620 
RLLEKAREEQ REIVKKHEED LHILHHRLEL QADSSLNKFK QTAWDLMKQS PTPVPTNKHF 

      1630       1640       1650       1660       1670       1680 
IRLAEMEQTV AEQDDSLSSL LVKLKKVSQD LERQREITEL KVKEFENIKL QLQENHEDEV 

      1690       1700       1710       1720       1730       1740 
KKVKAEVEDL KYLLDQSQKE SQCLKSELQA QKEANSRAPT TTMRNLVERL KSQLALKEKQ 

      1750       1760       1770       1780       1790       1800 
QKALSRALLE LRAEMTAAAE ERIISATSQK EAHLNVQQIV DRHTRELKTQ VEDLNENLLK 

      1810       1820       1830       1840       1850       1860 
LKEALKTSKN RENSLTDNLN DLNNELQKKQ KAYNKILREK EEIDQENDEL KRQIKRLTSG 

      1870       1880       1890       1900       1910       1920 
LQGKPLTDNK QSLIEELQRK VKKLENQLEG KVEEVDLKPM KEKNAKEELI RWEEGKKWQA 

      1930       1940       1950       1960       1970       1980 
KIEGIRNKLK EKEGEVFTLT KQLNTLKDLF AKADKEKLTL QRKLKTTGMT VDQVLGIRAL 

      1990       2000       2010       2020       2030       2040 
ESEKELEELK KRNLDLENDI LYMRAHQALP RDSVVEDLHL QNRYLQEKLH ALEKQFSKDT 

      2050       2060       2070       2080       2090       2100 
YSKPSISGIE SDDHCQREQE LQKENLKLSS ENIELKFQLE QANKDLPRLK NQVRDLKEMC 

      2110       2120       2130       2140       2150       2160 
EFLKKEKAEV QRKLGHVRGS GRSGKTIPEL EKTIGLMKKV VEKVQRENEQ LKKASGILTS 

      2170       2180       2190       2200       2210       2220 
EKMANIEQEN EKLKAELEKL KAHLGHQLSM HYESKTKGTE KIIAENERLR KELKKETDAA 

      2230       2240       2250       2260       2270       2280 
EKLRIAKNNL EILNEKMTVQ LEETGKRLQF AESRGPQLEG ADSKSWKSIV VTRMYETKLK 

      2290       2300       2310       2320       2330       2340 
ELETDIAKKN QSITDLKQLV KEATEREQKV NKYNEDLEQQ IKILKHVPEG AETEQGLKRE 

      2350       2360       2370       2380       2390       2400 
LQVLRLANHQ LDKEKAELIH QIEANKDQSG AESTIPDADQ LKEKIKDLET QLKMSDLEKQ 

      2410       2420       2430       2440       2450       2460 
HLKEEIKKLK KELENFDPSF FEEIEDLKYN YKEEVKKNIL LEEKVKKLSE QLGVELTSPV 

      2470 
AASEEFEDEE ESPVNFPIY

O15078 in FASTA format

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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools