[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND INTERACTION WITH STAM.
DOI=10.1074/jbc.272.52.32785; PubMed=9407053 [NCBI, ExPASy, EBI, Israel, Japan]
Asao H.,
Sasaki Y.,
Arita T.,
Tanaka N.,
Endo K.,
Kasai H.,
Takeshita T.,
Endo Y.,
Fujita T.,
Sugamura K.;
"Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth.";
J. Biol. Chem. 272:32785-32791(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Placenta;
DOI=10.1016/S0378-1119(98)00184-X; PubMed=9630564 [NCBI, ExPASy, EBI, Israel, Japan]
Lu L.,
Komada M.,
Kitamura N.;
"Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17.";
Gene 213:125-132(1998).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), DOMAIN, INTERACTION WITH NF2, AND SUBCELLULAR LOCATION.
TISSUE=Brain;
DOI=10.1093/hmg/9.11.1567; PubMed=10861283 [NCBI, ExPASy, EBI, Israel, Japan]
Scoles D.R.,
Huynh D.P.,
Chen M.S.,
Burke S.P.,
Gutmann D.H.,
Pulst S.-M.;
"The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate.";
Hum. Mol. Genet. 9:1567-1574(2000).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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SUBCELLULAR LOCATION.
DOI=10.1074/jbc.272.33.20538; PubMed=9252367 [NCBI, ExPASy, EBI, Israel, Japan]
Komada M.,
Masaki R.,
Yamamoto A.,
Kitamura N.;
"Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes.";
J. Biol. Chem. 272:20538-20544(1997).
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[7]
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INTERACTION WITH STAM; STAM2 AND EPS15, AND IDENTIFIACTION IN A COMPLEX WITH STAM2 AND EPS15.
DOI=10.1074/jbc.M210843200; PubMed=12551915 [NCBI, ExPASy, EBI, Israel, Japan]
Bache K.G.,
Raiborg C.,
Mehlum A.,
Stenmark H.;
"STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes.";
J. Biol. Chem. 278:12513-12521(2003).
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[8]
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INTERACTION WITH HIV-1 GAG AND HGS, AND SELF-ASSOCIATION.
DOI=10.1083/jcb.200302138; PubMed=12900394 [NCBI, ExPASy, EBI, Israel, Japan]
Pornillos O.,
Higginson D.S.,
Stray K.M.,
Fisher R.D.,
Garrus J.E.,
Payne M.,
He G.P.,
Wang H.E.,
Morham S.G.,
Sundquist W.I.;
"HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein.";
J. Cell Biol. 162:425-434(2003).
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[9]
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INTERACTION WITH VPS37C.
DOI=10.1074/jbc.M410384200; PubMed=15509564 [NCBI, ExPASy, EBI, Israel, Japan]
Eastman S.W.,
Martin-Serrano J.,
Chung W.,
Zang T.,
Bieniasz P.D.;
"Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.";
J. Biol. Chem. 280:628-636(2005).
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[10]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-308, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1021/pr050134h; PubMed=16212419 [NCBI, ExPASy, EBI, Israel, Japan]
Amanchy R.,
Kalume D.E.,
Iwahori A.,
Zhong J.,
Pandey A.;
"Phosphoproteome analysis of HeLa cells using stable isotope labeling with amino acids in cell culture (SILAC).";
J. Proteome Res. 4:1661-1671(2005).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-216, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-132 AND TYR-216, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K.,
Guo A.,
Zeng Q.,
Possemato A.,
Yu J.,
Haack H.,
Nardone J.,
Lee K.,
Reeves C.,
Li Y.,
Hu Y.,
Tan Z.,
Stokes M.,
Sullivan L.,
Mitchell J.,
Wetzel R.,
Macneill J.,
Ren J.M.,
Yuan J., ![]()
Bakalarski C.E.,
Villen J.,
Kornhauser J.M.,
Smith B.,
Li D.,
Zhou X.,
Gygi S.P.,
Gu T.-L.,
Polakiewicz R.D.,
Rush J.,
Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
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[13]
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IDENTIFICATION [LARGE SCALE ANALYSIS], AND MASS SPECTROMETRY.
Colinge J.,
Superti-Furga G.,
Bennett K.L.;
Submitted (OCT-2008) to UniProtKB.
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[14]
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X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 257-277 IN COMPLEX WITH UBIQUITIN, AND MUTAGENESIS OF ALA-266 AND ALA-268.
DOI=10.1038/nsmb1051; PubMed=16462748 [NCBI, ExPASy, EBI, Israel, Japan]
Hirano S.,
Kawasaki M.,
Ura H.,
Kato R.,
Raiborg C.,
Stenmark H.,
Wakatsuki S.;
"Double-sided ubiquitin binding of Hrs-UIM in endosomal protein sorting.";
Nat. Struct. Mol. Biol. 13:272-277(2006).
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[15]
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VARIANT [LARGE SCALE ANALYSIS] SER-7.
DOI=10.1038/nature07485; PubMed=18987736 [NCBI, ExPASy, EBI, Israel, Japan]
Ley T.J.,
Mardis E.R.,
Ding L.,
Fulton B.,
McLellan M.D.,
Chen K.,
Dooling D.,
Dunford-Shore B.H.,
McGrath S.,
Hickenbotham M.,
Cook L.,
Abbott R.,
Larson D.E.,
Koboldt D.C.,
Pohl C.,
Smith S.,
Hawkins A.,
Abbott S.,
Locke D., ![]()
Hillier L.W.,
Miner T.,
Fulton L.,
Magrini V.,
Wylie T.,
Glasscock J.,
Conyers J.,
Sander N.,
Shi X.,
Osborne J.R.,
Minx P.,
Gordon D.,
Chinwalla A.,
Zhao Y.,
Ries R.E.,
Payton J.E.,
Westervelt P.,
Tomasson M.H.,
Watson M.,
Baty J.,
Ivanovich J.,
Heath S.,
Shannon W.D.,
Nagarajan R.,
Walter M.J.,
Link D.C.,
Graubert T.A.,
DiPersio J.F.,
Wilson R.K.;
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome.";
Nature 456:66-72(2008).
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