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UniProtKB/Swiss-Prot entry O14931


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NCTR3_HUMAN
Primary accession number O14931
Secondary accession numbers O14930 O14932 O95667 O95668 O95669 Q5ST89 Q5ST90 Q5ST91 Q5ST92 Q5STA3
Integrated into Swiss-Prot on May 24, 2004
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 79)
Name and origin of the protein
Protein name Natural cytotoxicity triggering receptor 3 [Precursor]
Synonyms Natural killer cell p30-related protein
NK-p30
NKp30
Activating natural killer receptor p30
CD337 antigen
Gene name
Name: NCR3
Synonyms: 1C7, LY117
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH CD3Z, AND FUNCTION.
TISSUE=Lymphoid;
DOI=10.1084/jem.190.10.1505; PubMed=10562324 [NCBI, ExPASy, EBI, Israel, Japan]
Pende D., Parolini S., Pessino A., Sivori S., Augugliaro R., Morelli L., Marcenaro E., Accame L., Malaspina A., Biassoni R., Bottino C., Moretta L., Moretta A.;
"Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.";
J. Exp. Med. 190:1505-1516(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND INTERACTION WITH CD3Z.
TISSUE=Peripheral blood;
Sato M., Yabe T., Ohashi J., Tsuchiya N., Hanaoka K., Tokunaga K., Juji T.;
"Identificastion of two novel single nucleotide polymorphisms in the NKp30 gene in human natural killer cells.";
Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6).
PubMed=10202016 [NCBI, ExPASy, EBI, Israel, Japan]
Neville M.J., Campbell R.D.;
"A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.";
J. Immunol. 162:4745-4754(1999).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
TISSUE=Spleen;
DOI=10.1006/geno.1996.0034; PubMed=8824804 [NCBI, ExPASy, EBI, Israel, Japan]
Nalabolu S.R., Shukla H., Nallur G., Parimoo S., Weissman S.M.;
"Genes in a 220-kb region spanning the TNF cluster in human MHC.";
Genomics 31:215-222(1996).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.1736803; PubMed=14656967 [NCBI, ExPASy, EBI, Israel, Japan]
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.;
"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.";
Genome Res. 13:2621-2636(2003).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Shiina S., Tamiya G., Oka A., Inoko H.;
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Blood;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
INVOLVEMENT IN MILD MALARIA SUSCEPTIBILITY.
DOI=10.1016/j.micinf.2006.11.002; PubMed=17208487 [NCBI, ExPASy, EBI, Israel, Japan]
Delahaye N.F., Barbier M., Fumoux F., Rihet P.;
"Association analyses of NCR3 polymorphisms with P. falciparum mild malaria.";
Microbes Infect. 9:160-166(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ223153; CAB54004.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB055881; BAB78472.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14768; CAA75063.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14768; CAA75064.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14768; CAA75065.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14768; CAA75066.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14768; CAA75067.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Y14768; CAA75068.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF031136; AAB86578.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF031137; AAB86579.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF031138; AAB86580.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF129756; AAD18088.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000025; BAB63393.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662847; CAI17688.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662847; CAI17689.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662847; CAI17690.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662847; CAI17691.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662801; CAI18302.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662801; CAI18303.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662801; CAI18304.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL662801; CAI18305.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929587; CAI18660.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929587; CAI18661.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929587; CAI18662.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL929587; CAI18663.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248519; CAI41953.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248519; CAI41954.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248519; CAI41955.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248519; CAI41956.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC052582; AAH52582.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00011558; -.
IPI00013125; -.
IPI00032121; -.
IPI00383788; -.
IPI00384964; -.
IPI00411498; -.
RefSeq NP_001138938.1; -.
NP_001138939.1; -.
NP_667341.1; -.
UniGene Hs.509513
3D structure databases
ModBase O14931.
Organism-specific databases
GeneCards GC06M031664; -.
H-InvDB HIX0025010; -.
HIX0057972; -.
HIX0058155; -.
HGNC HGNC:19077; NCR3.
GenAtlas NCR3.
MIM 609148; phenotype. [NCBI / EBI]
611550; gene. [NCBI / EBI]
PharmGKB PA134883693; -.
Gene expression databases
Bgee O14931; -.
GermOnline ENSG00000204475; Homo sapiens.
Ontologies
GO
GO:0005887; Cellular component: integral to plasma membrane (traceable author statement from ProtInc).
GO:0004872; Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0008037; Biological process: cell recognition (traceable author statement from UniProtKB).
GO:0006955; Biological process: immune response (non-traceable author statement from UniProtKB).
GO:0006954; Biological process: inflammatory response (non-traceable author statement from UniProtKB).
GO:0045954; Biological process: positive regulation of natural killer cell mediated cytotoxicity (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF07686; V-set; 1.
Pfam graphical view of domain structure.
SMART SM00409; IG; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 1.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PRIDE O14931; -.
Genome annotation databases
Ensembl ENSG00000204475; Homo sapiens. [Contig view]
ENSG00000206321; Homo sapiens. [Contig view]
ENSG00000206430; Homo sapiens. [Contig view]
GeneID 259197; -.
KEGG hsa:259197; -.
Phylogenomic databases
HOVERGEN O14931; -.
OMA O14931; GVYVCRV.
Other
NextBio 93046; -.
SOURCE NCR3; Homo sapiens.
ProtoNet O14931.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    18  18     Potential. 
CHAIN   19   201  183     Natural cytotoxicity triggering receptor 3. PRO_0000015032
TOPO_DOM   19   135  117     Extracellular (Potential). 
TRANSMEM   136   156  21     Potential. 
TOPO_DOM   157   201  45     Cytoplasmic (Potential). 
DOMAIN   19   126  108     Ig-like. 
CARBOHYD   42    42        N-linked (GlcNAc...) (Potential). 
CARBOHYD   121   121        N-linked (GlcNAc...) (Potential). 
DISULFID   39   108        By similarity. 
VAR_SEQ   66    90        Missing (in isoform 4, isoform 5 and isoform 6). VSP_010411
VAR_SEQ   166   201        CLTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG -> YAKSTLSGFPQL (in isoform 3 and isoform 6). VSP_010412
VAR_SEQ   167   201        LTWKGPRRQLPAVVPAPLPPPCGSSAHLLPPVPGG -> HCHMGTHCHSSDGPRGVIPEPRCP (in isoform 2 and isoform 5). VSP_010413
VARIANT   103   103  1     A -> T (in dbSNP:rs11575840 [NCBI]). VAR_044114 
VARIANT   174   174  1     R -> S (in dbSNP:rs3179003 [NCBI]). VAR_044115 
Sequence information
Length: 201 AA [This is the length of the unprocessed precursor] Molecular weight: 21593 Da [This is the MW of the unprocessed precursor] CRC64: 2855AE4D6902D429 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV 

        70         80         90        100        110        120 
VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG HDASIYVCRV EVLGLGVGTG 

       130        140        150        160        170        180 
NGTRLVVEKE HPQLGAGTVL LLRAGFYAVS FLSVAVGSTV YYQGKCLTWK GPRRQLPAVV 

       190        200 
PAPLPPPCGS SAHLLPPVPG G 

O14931 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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