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UniProtKB/Swiss-Prot entry O14810


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CPLX1_HUMAN
Primary accession number O14810
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 63)
Name and origin of the protein
Protein name Complexin-1
Synonyms Complexin I
CPX I
Synaphin-2
Gene name
Name: CPLX1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1016/0092-8674(95)90239-2; PubMed=7553862 [NCBI, ExPASy, EBI, Israel, Japan]
McMahon H.T., Missler M., Li C., Suedhof T.C.;
"Complexins: cytosolic proteins that regulate SNAP receptor function.";
Cell 83:111-119(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Eye;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY.
DOI=10.1016/S0140-6736(98)03341-8; PubMed=9853440 [NCBI, ExPASy, EBI, Israel, Japan]
Harrison P.J., Eastwood S.L.;
"Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia.";
Lancet 352:1669-1673(1998).
[6]
TISSUE SPECIFICITY.
DOI=10.1016/S0306-4522(01)00141-5; PubMed=11483314 [NCBI, ExPASy, EBI, Israel, Japan]
Eastwood S.L., Cotter D., Harrison P.J.;
"Cerebellar synaptic protein expression in schizophrenia.";
Neuroscience 105:219-229(2001).
[7]
IDENTIFICATION BY MASS SPECTROMETRY, AND DISEASE.
DOI=10.1002/pmic.200400848; PubMed=15526345 [NCBI, ExPASy, EBI, Israel, Japan]
Basso M., Giraudo S., Corpillo D., Bergamasco B., Lopiano L., Fasano M.;
"Proteome analysis of human substantia nigra in Parkinson's disease.";
Proteomics 4:3943-3952(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF022383; AAB72108.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT007029; AAP35676.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC139887; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC002471; AAH02471.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00396023; -.
RefSeq NP_006642.1; -.
UniGene Hs.478930
3D structure databases
HSSP Q64276; 1KIL. [HSSP ENTRY / PDB]
ModBase O14810.
PTM databases
PhosphoSite O14810; -.
Enzyme and pathway databases
Reactome REACT_13685; Synaptic Transmission.
Organism-specific databases
GeneCards GC04M000771; -.
H-InvDB HIX0004006; -.
HGNC HGNC:2309; CPLX1.
GenAtlas CPLX1.
MIM 605032; gene. [NCBI / EBI]
PharmGKB PA26826; -.
Gene expression databases
CleanEx HS_CPLX1; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from electronic annotation from UniProtKB-SubCell).
GO:0019905; Molecular function: syntaxin binding (inferred from electronic annotation from InterPro).
GO:0006887; Biological process: exocytosis (traceable author statement from ProtInc).
GO:0006836; Biological process: neurotransmitter transport (inferred from electronic annotation from UniProtKB-KW).
GO:0007268; Biological process: synaptic transmission (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR008849; Synaphin.
Graphical view of domain structure.
PANTHER PTHR16705; Synaphin; 1.
Pfam PF05835; Synaphin; 1.
Pfam graphical view of domain structure.
Proteomic databases
PeptideAtlas O14810; -.
PRIDE O14810; -.
Genome annotation databases
GeneID 10815; -.
KEGG hsa:10815; -.
Phylogenomic databases
HOVERGEN O14810; -.
Other
NextBio 41085; -.
SOURCE CPLX1; Homo sapiens.
ProtoNet O14810.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Coiled coil; Cytoplasm; Exocytosis; Neurotransmitter transport; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom  To Length Description FTId
CHAIN   1   134  134     Complexin-1. PRO_0000144870
REGION   48    70  23     Interaction with the SNARE complex (By similarity). 
COILED   29    69  41     Potential. 
Sequence information
Length: 134 AA [This is the length of the unprocessed precursor] Molecular weight: 15030 Da [This is the MW of the unprocessed precursor] CRC64: A7A52F17F10D28A4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEFVMKQALG GATKDMGKML GGDEEKDPDA AKKEEERQEA LRQAEEERKA KYAKMEAERE 

        70         80         90        100        110        120 
AVRQGIRDKY GIKKKEEREA EAQAAMEANS EGSLTRPKKA IPPGCGDEVE EEDESILDTV 

       130 
IKYLPGPLQD MLKK 

O14810 in FASTA format

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