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UniProtKB/Swiss-Prot entry O14594

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NCAN_HUMAN
Primary accession number O14594
Secondary accession number Q9UPK6
Integrated into Swiss-Prot on January 27, 2003
Sequence was last modified on November 13, 2007 (Sequence version 3)
Annotations were last modified on    June 16, 2009 (Entry version 83)
Name and origin of the protein
Protein name Neurocan core protein [Precursor]
Synonym Chondroitin sulfate proteoglycan 3
Gene name
Name: NCAN
Synonyms: CSPG3, NEUR
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT VAL-1254.
DOI=10.1016/S0378-1119(98)00455-7; PubMed=9795216 [NCBI, ExPASy, EBI, Israel, Japan]
Prange C.K., Pennacchio L.A., Lieuallen K., Fan W., Lennon G.G.;
"Characterization of the human neurocan gene, CSPG3.";
Gene 221:199-205(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF026547; AAC80576.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC003110; AAB86655.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC005254; AAC25581.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00159927; -.
RefSeq NP_004377.2; -.
UniGene Hs.169047
3D structure databases
HSSP P00740; 1EDM. [HSSP ENTRY / PDB]
ModBase O14594.
Enzyme and pathway databases
Pathway_Interaction_DB syndecan_3_pathway; Syndecan-3-mediated signaling events.
Organism-specific databases
GeneCards GC19P019183; -.
H-InvDB HIX0027449; -.
HGNC HGNC:2465; NCAN.
GenAtlas NCAN.
MIM 600826; gene. [NCBI / EBI]
PharmGKB PA26962; -.
Gene expression databases
ArrayExpress O14594; -.
Bgee O14594; -.
CleanEx HS_NCAN; -.
GermOnline ENSG00000130287; Homo sapiens.
Ontologies
GO
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005540; Molecular function: hyaluronic acid binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005529; Molecular function: sugar binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002353; AntifreezeII.
IPR001304; C-type_lectin.
IPR016186; C-type_lectin-like.
IPR018378; C-type_lectin_CS.
IPR016060; Complement_control_module.
IPR006209; EGF.
IPR006210; EGF-like.
IPR013032; EGF-like_reg_CS.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR018097; EGF_Ca_bd_CS.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR000538; Link.
IPR000436; Sushi_SCR_CCP.
Graphical view of domain structure.
Gene3D G3DSA:3.10.100.10; C-type_lectin-like; 3.
G3DSA:2.10.70.10; Complement_control_module; 1.
G3DSA:2.60.40.10; Ig-like_fold; 1.
Pfam PF00008; EGF; 2.
PF00059; Lectin_C; 1.
PF00084; Sushi; 1.
PF00193; Xlink; 2.
Pfam graphical view of domain structure.
PRINTS PR00356; ANTIFREEZEII.
PR01265; LINKMODULE.
ProDom PD000918; Link; 2.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00032; CCP; 1.
SM00034; CLECT; 1.
SM00181; EGF; 1.
SM00179; EGF_CA; 1.
SM00409; IG; 1.
SM00445; LINK; 2.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 1.
PS00615; C_TYPE_LECTIN_1; 1.
PS50041; C_TYPE_LECTIN_2; 1.
PS00022; EGF_1; 3.
PS01186; EGF_2; 1.
PS50026; EGF_3; 2.
PS01187; EGF_CA; 1.
PS50835; IG_LIKE; 1.
PS01241; LINK_1; 2.
PS50963; LINK_2; 2.
PS50923; SUSHI; 1.
PROSITE graphical view of domain structure (profiles).
Genome annotation databases
Ensembl ENSG00000130287; Homo sapiens. [Contig view]
GeneID 1463; -.
KEGG hsa:1463; -.
Phylogenomic databases
HOVERGEN O14594; -.
OMA O14594; QPHPEPE.
Other
NextBio 6009; -.
SOURCE NCAN; Homo sapiens.
ProtoNet O14594.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Disulfide bond; EGF-like domain; Glycoprotein; Hyaluronic acid; Immunoglobulin domain; Lectin; Polymorphism; Proteoglycan; Repeat; Signal; Sushi.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
SIGNAL   1     22  22     Potential. 
CHAIN   23   1321  1299     Neurocan core protein. PRO_0000017516
DOMAIN   38    153  116     Ig-like V-type. 
DOMAIN   160    255  96     Link 1. 
DOMAIN   259    357  99     Link 2. 
DOMAIN   1008   1044  37     EGF-like 1. 
DOMAIN   1046   1082  37     EGF-like 2; calcium-binding (Potential). 
DOMAIN   1084   1213  130     C-type lectin. 
DOMAIN   1213   1273  61     Sushi. 
CARBOHYD   122    122        N-linked (GlcNAc...) (Potential). 
CARBOHYD   340    340        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1026   1026        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1223   1223        N-linked (GlcNAc...) (Potential). 
DISULFID   59    140        By similarity. 
DISULFID   182    253        By similarity. 
DISULFID   206    227        By similarity. 
DISULFID   280    355        By similarity. 
DISULFID   304    325        By similarity. 
DISULFID   1012   1023        By similarity. 
DISULFID   1017   1032        By similarity. 
DISULFID   1034   1043        By similarity. 
DISULFID   1050   1061        By similarity. 
DISULFID   1055   1070        By similarity. 
DISULFID   1072   1081        By similarity. 
DISULFID   1088   1099        By similarity. 
DISULFID   1116   1208        By similarity. 
DISULFID   1184   1200        By similarity. 
DISULFID   1215   1258        By similarity. 
DISULFID   1244   1271        By similarity. 
VARIANT   70     70  1     A -> T (in dbSNP:rs2228601 [NCBI]). VAR_024521 
VARIANT   92     92  1     P -> S (in dbSNP:rs2228603 [NCBI]). VAR_020213 
VARIANT   1254   1254  1     A -> V (in dbSNP:rs1064389 [NCBI]). VAR_016176 
CONFLICT   1234   1234        Y -> N (in Ref. 1; AAC80576). 
CONFLICT   1282   1282        R -> G (in Ref. 1; AAC80576). 
Sequence information
Length: 1321 AA [This is the length of the unprocessed precursor] Molecular weight: 143093 Da [This is the MW of the unprocessed precursor] CRC64: 22E21FFA24CE9FB2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGAPFVWALG LLMLQMLLFV AGEQGTQDIT DASERGLHMQ KLGSGSVQAA LAELVALPCL 

        70         80         90        100        110        120 
FTLQPRPSAA RDAPRIKWTK VRTASGQRQD LPILVAKDNV VRVAKSWQGR VSLPSYPRRR 

       130        140        150        160        170        180 
ANATLLLGPL RASDSGLYRC QVVRGIEDEQ DLVPLEVTGV VFHYRSARDR YALTFAEAQE 

       190        200        210        220        230        240 
ACRLSSAIIA APRHLQAAFE DGFDNCDAGW LSDRTVRYPI TQSRPGCYGD RSSLPGVRSY 

       250        260        270        280        290        300 
GRRNPQELYD VYCFARELGG EVFYVGPARR LTLAGARAQC RRQGAALASV GQLHLAWHEG 

       310        320        330        340        350        360 
LDQCDPGWLA DGSVRYPIQT PRRRCGGPAP GVRTVYRFAN RTGFPSPAER FDAYCFRAHH 

       370        380        390        400        410        420 
PTSQHGDLET PSSGDEGEIL SAEGPPVREL EPTLEEEEVV TPDFQEPLVS SGEEETLILE 

       430        440        450        460        470        480 
EKQESQQTLS PTPGDPMLAS WPTGEVWLST VAPSPSDMGA GTAASSHTEV APTDPMPRRR 

       490        500        510        520        530        540 
GRFKGLNGRY FQQQEPEPGL QGGMEASAQP PTSEAAVNQM EPPLAMAVTE MLGSGQSRSP 

       550        560        570        580        590        600 
WADLTNEVDM PGAGSAGGKS SPEPWLWPPT MVPPSISGHS RAPVLELEKA EGPSARPATP 

       610        620        630        640        650        660 
DLFWSPLEAT VSAPSPAPWE AFPVATSPDL PMMAMLRGPK EWMLPHPTPI STEANRVEAH 

       670        680        690        700        710        720 
GEATATAPPS PAAETKVYSL PLSLTPTGQG GEAMPTTPES PRADFRETGE TSPAQVNKAE 

       730        740        750        760        770        780 
HSSSSPWPSV NRNVAVGFVP TETATEPTGL RGIPGSESGV FDTAESPTSG LQATVDEVQD 

       790        800        810        820        830        840 
PWPSVYSKGL DASSPSAPLG SPGVFLVPKV TPNLEPWVAT DEGPTVNPMD STVTPAPSDA 

       850        860        870        880        890        900 
SGIWEPGSQV FEEAESTTLS PQVALDTSIV TPLTTLEQGD KVGVPAMSTL GSSSSQPHPE 

       910        920        930        940        950        960 
PEDQVETQGT SGASVPPHQS SPLGKPAVPP GTPTAASVGE SASVSSGEPT VPWDPSSTLL 

       970        980        990       1000       1010       1020 
PVTLGIEDFE LEVLAGSPGV ESFWEEVASG EEPALPGTPM NAGAEEVHSD PCENNPCLHG 

      1030       1040       1050       1060       1070       1080 
GTCNANGTMY GCSCDQGFAG ENCEIDIDDC LCSPCENGGT CIDEVNGFVC LCLPSYGGSF 

      1090       1100       1110       1120       1130       1140 
CEKDTEGCDR GWHKFQGHCY RYFAHRRAWE DAEKDCRRRS GHLTSVHSPE EHSFINSFGH 

      1150       1160       1170       1180       1190       1200 
ENTWIGLNDR IVERDFQWTD NTGLQFENWR ENQPDNFFAG GEDCVVMVAH ESGRWNDVPC 

      1210       1220       1230       1240       1250       1260 
NYNLPYVCKK GTVLCGPPPA VENASLIGAR KAKYNVHATV RYQCNEGFAQ HHVATIRCRS 

      1270       1280       1290       1300       1310       1320 
NGKWDRPQIV CTKPRRSHRM RRHHHHHQHH HQHHHHKSRK ERRKHKKHPT EDWEKDEGNF 


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O14594 in FASTA format

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