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UniProtKB/Swiss-Prot entry O14057


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAD_SCHPO
Primary accession number O14057
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 50)
Name and origin of the protein
Protein name Probable guanine deaminase
Synonyms Guanase
Guanine aminase
EC 3.5.4.3
Guanine aminohydrolase
GAH
Gene name
ORFNames: SPCC1672.03c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329672; CAA20441.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T41047; T41047.
RefSeq NP_587874.1; -.
3D structure databases
ModBase O14057.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-002219-MON; -.
Organism-specific databases
GeneDB_Spombe SPCC1672.03c; -.
Gene expression databases
ArrayExpress O14057; -.
Ontologies
GO
GO:0005829; Cellular component: cytosol (inferred from direct assay from GeneDB_SPombe).
GO:0008892; Molecular function: guanine deaminase activity (inferred from electronic annotation from InterPro).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006680; Amidohydro_1.
IPR014311; Guanine_deaminase.
Graphical view of domain structure.
PANTHER PTHR11271:SF6; Guanine_deaminase; 1.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR02967; guan_deamin; 1.
Genome annotation databases
GeneID 2539231; -.
KEGG spo:SPCC1672.03c; -.
NMPDR fig|4896.1.peg.212; -.
Other
ProtoNet O14057.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   527  527     Probable guanine deaminase. PRO_0000122301
METAL   79    79        Zinc; via tele nitrogen (By similarity). 
METAL   81    81        Zinc; via tele nitrogen (By similarity). 
METAL   239   239        Zinc; via tele nitrogen (By similarity). 
METAL   329   329        Zinc (By similarity). 
BINDING   84    84        Substrate (By similarity). 
BINDING   212   212        Substrate (By similarity). 
BINDING   242   242        Substrate (By similarity). 
BINDING   278   278        Substrate (By similarity). 
Sequence information
Length: 527 AA [This is the length of the unprocessed precursor] Molecular weight: 58047 Da [This is the MW of the unprocessed precursor] CRC64: 23D9A3F1117601C1 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDGHTCDVFV GKLIHTPSLG ELEITDATVG VYNGKIVFLE KSMTPKTLEE AKSHHLLKEA 

        70         80         90        100        110        120 
TIHKLKPLQF MFPGLIDTHI HAPQYPNSGI GIDVPLLQWL EKYTFPLESS LADLEEARQV 

       130        140        150        160        170        180 
YKRVVERTLS NGTTFASYFS TLHTPTSALL AEICYSYGQR AYIGKCNMNN LSPDHYCEKS 

       190        200        210        220        230        240 
AESSLEATRQ LISYMSILDP KREMVTPIIT PRFAPSCTED LLSGCGELAE KHNLPIQTHI 

       250        260        270        280        290        300 
SENTSEIELV KELFPERKSY ADVYDYYKLL TPQTILAHAI HLEDEEIELL TKRSSGISHC 

       310        320        330        340        350        360 
PTSNSILASG LANVRKLLDS GINVGLGTDV SGGYAPSILI ALRHAAMTSR SLSYVLGDPK 

       370        380        390        400        410        420 
VMLDLSELLY LATQGGAEVV SRGDQVGSFA VGKYWDALIV DLSAETHSCV DIFERDTWPV 

       430        440        450        460        470        480 
MLSKWVFTSD DRNLAQVWVN GRLVSGFEMK ANLKNSTPLT NGVTSSGHQV FKELTQAHLL 

       490        500        510        520 
PRTQCVDTPP SCCGGHCCKE ESCRTENCKG AYPANATVTV EEDSGMS 

O14057 in FASTA format

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