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UniProtKB/Swiss-Prot entry O13359

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KEX2_CANAL
Primary accession number O13359
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 56)
Name and origin of the protein
Protein name Kexin [Precursor]
Synonyms EC 3.4.21.61
KEX2 protease
Gene name
Name: KEX2
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=WO-1;
DOI=10.1074/jbc.272.46.28954; PubMed=9360967 [NCBI, ExPASy, EBI, Israel, Japan]
Newport G.R., Agabian N.;
"KEX2 influences Candida albicans proteinase secretion and hyphal formation.";
J. Biol. Chem. 272:28954-28961(1997).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF022372; AAB80929.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P13134; 1OT5. [HSSP ENTRY / PDB]
ModBase O13359.
Protein family/group databases
MEROPS S08.070; -.
Ontologies
GO
GO:0005794; Cellular component: Golgi apparatus (inferred from electronic annotation from UniProtKB-KW).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004252; Molecular function: serine-type endopeptidase activity (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000209; Pept_S8_S53.
IPR015500; Peptidase_S8_subtilisin-rel.
IPR002884; PrprotnconvertsP.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.200; Pept_S8_S53; 1.
PANTHER PTHR10795; SubtilSerProt; 1.
Pfam PF01483; P_proprotein; 1.
PF00082; Peptidase_S8; 1.
Pfam graphical view of domain structure.
PRINTS PR00723; SUBTILISIN.
ProDom PD000717; PrprotnconvertsP; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00136; SUBTILASE_ASP; FALSE_NEG.
PS00137; SUBTILASE_HIS; 1.
PS00138; SUBTILASE_SER; 1.
Other
ProtoNet O13359.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Glycoprotein; Golgi apparatus; Hydrolase; Membrane; Protease; Serine protease; Signal; Transmembrane; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
PROPEP   21     ?        Potential. PRO_0000027041
CHAIN   ?   924        Kexin. PRO_0000027042
TOPO_DOM   ?   774        Lumenal (Potential). 
TRANSMEM   775   795  21     Potential. 
TOPO_DOM   796   924  129     Cytoplasmic (Potential). 
REGION   190   447  258     Catalytic. 
COMPBIAS   675   729  55     Ser/Thr-rich. 
COMPBIAS   678   681  4     Poly-Thr. 
COMPBIAS   803   808  6     Poly-Arg. 
COMPBIAS   894   903  10     Poly-Glu. 
ACT_SITE   213   213        Charge relay system (By similarity). 
ACT_SITE   251   251        Charge relay system (By similarity). 
ACT_SITE   422   422        Charge relay system (By similarity). 
CARBOHYD   41    41        N-linked (GlcNAc...) (Potential). 
CARBOHYD   193   193        N-linked (GlcNAc...) (Potential). 
CARBOHYD   441   441        N-linked (GlcNAc...) (Potential). 
CARBOHYD   512   512        N-linked (GlcNAc...) (Potential). 
CARBOHYD   539   539        N-linked (GlcNAc...) (Potential). 
CARBOHYD   599   599        N-linked (GlcNAc...) (Potential). 
DISULFID   267   414        By similarity. 
DISULFID   359   389        By similarity. 
Sequence information
Length: 924 AA [This is the length of the unprocessed precursor] Molecular weight: 103497 Da [This is the MW of the unprocessed precursor] CRC64: 49E5C2093FCCCCE2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLPIKLLIFI LGYLLSPTLQ QYQQIPPRDY ENKNYFLVEL NTTNSQKPLI DFISHYRGHY 

        70         80         90        100        110        120 
NFEHQLSSLD NHYVFSIDKS HPHNSFLGNH NSNEYNLMKR QLGHEQDYDE LISHVESIHL 

       130        140        150        160        170        180 
LPMKKLSKRI PVPIEMEDVV FDNRDDTGSD NHEATDEAHQ KLIEIAKKLD IHDPEFTTQW 

       190        200        210        220        230        240 
HLINLKYPGH DVNVTGLWLE DILGQGIVTA LVDDGVDAES DDIKQNFNSE GSWDFNNKGK 

       250        260        270        280        290        300 
SPLPRLFDDY HGTRCAGEIA AVKNDVCGIG VAWKSQVSGI RILSGPITSS DEAEAMVYGL 

       310        320        330        340        350        360 
DTNDIYSCSW GPTDNGKVLS EPDVIVKKAM IKGIQEGRDK KGAIYVFASG NGGRFGDSCN 

       370        380        390        400        410        420 
FDGYTNSIYS ITVGAIDYKG LHPQYSEACS AVMVVTYSSG SGEHIHTTDI KKKCSATHGG 

       430        440        450        460        470        480 
TSAAAPLASG IYSLILSANP NLTWRDVQYI SVLSATPINE EDGNYQTTAL NRKYSHKYGY 

       490        500        510        520        530        540 
GKTDAYKMVH FAKTWVNVKP QAWYYSDIIE VNQTITTTPE QKAPSKRDSP QKIIHSSVNV 

       550        560        570        580        590        600 
SEKDLKIMNV ERVEHITVKV NIDSTYRGRV GMRIISPTGV ISDLATFRVN DASTRGFQNW 

       610        620        630        640        650        660 
TFMSVAHWGE TGIGEWKVEV FVDDSKGDQV EINFKDWQFR IFGESIDGDK AEVYDITKDY 

       670        680        690        700        710        720 
AAIRRELLEK EKQNSKSTTT TSSTTTATTT SGGEGDQKTT TSAENKESTT KVDNSASITT 

       730        740        750        760        770        780 
SQTASLTSSN EQHQPTESNS DSDSDTDDEN KQEGEEDNDN DNDNGNKKAN SDNTGFYLMS 

       790        800        810        820        830        840 
IAVVGFIAVL LVMKFHKTPG SGRRRRRRDG YEFDIIPGED YSDSDDDEDD SDTRRADDDS 

       850        860        870        880        890        900 
FDLGHRNDQR VVSASQQQRQ YDRQQDEARD RLFDDFNAES LPDYENDMFK IGDEEEEEEE 

       910        920 
EEEGQQSAKA PSNSEGNSGT STKK
O13359 in FASTA format

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