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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
Yoshida K.;
"Murine MLL2 gene and its expression.";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [MRNA] OF 379-657.
DOI=10.1093/emboj/16.9.2376; PubMed=9171351 [NCBI, ExPASy, EBI, Israel, Japan]
Bedford M.T.,
Chan D.C.,
Leder P.;
"FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands.";
EMBO J. 16:2376-2383(1997).
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[3]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1927, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1073/pnas.0609836104; PubMed=17242355 [NCBI, ExPASy, EBI, Israel, Japan]
Villen J.,
Beausoleil S.A.,
Gerber S.A.,
Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
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[4]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S.,
Ballif B.A.,
Smogorzewska A.,
McDonald E.R. III,
Hurov K.E.,
Luo J.,
Bakalarski C.E.,
Zhao Z.,
Solimini N.,
Lerenthal Y.,
Shiloh Y.,
Gygi S.P.,
Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
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- FUNCTION: Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity).
- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine.
- SUBUNIT: Component of the MLL3/MLL4 complex, at least composed of MLL3, MLL4, ASH2L, RBBP5, DPY30, WDR5, NCOA6, UTX (or JMJD3), PAXIP1/PTIP and C16orf53/PA1 (By similarity).
- SUBCELLULAR LOCATION: Nucleus (By similarity).
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
- SIMILARITY: Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily.
- SIMILARITY: Contains 3 A.T hook DNA-binding domains.
- SIMILARITY: Contains 1 CXXC-type zinc finger.
- SIMILARITY: Contains 3 PHD-type zinc fingers.
- SIMILARITY: Contains 1 post-SET domain.
- SIMILARITY: Contains 1 SET domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 2713 AA [This is the length of the unprocessed precursor] |
Molecular weight: 294836 Da [This is the MW of the unprocessed precursor] |
CRC64: B24BCA2D019EB055 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAAAAGGGSC PGPGSARVRF PGRPLGCGGG GGRGGRGNGA ERVRVALRRG GGAAGPGGAE
70 80 90 100 110 120
PGEDTALLRL LGLRRGLRRL RRLWAGARVQ RGRGRGRGRG WGPNRGCMPE EESSDGESEE
130 140 150 160 170 180
EEFQGFHSDE DVAPSSLRSA LRSQRGRAPR GRGRKHKTTP LPPRLADVTP VPPKAPTRKR
190 200 210 220 230 240
GEEGTERMVQ ALTELLRRSQ APQPPRSRAR AREPSTPRRS RGRPPGRPAG PCRKKQQAVV
250 260 270 280 290 300
LAEAAVTIPK PEPPPPVVPV KNKAGSWKCK EGPGPGPGTP KRGGQPGRGG RGGRGRGRGG
310 320 330 340 350 360
LPLMIKFVSK AKKVKMGQLS QELESGQGHG QRGESWQDAP QRKDGDEPER GSCRKKQEQK
370 380 390 400 410 420
LEEEEEEEEK EGEEKEEKDD NEDNNKQEEE EETERAVAEE EAMLAKEKEE AKLPSPPLTP
430 440 450 460 470 480
PVPSPPPPLP PPSTSPPPPA SPLPPPVSPP PPLSPPPYPA PEKQEESPPL VPATCSRKRG
490 500 510 520 530 540
RPPLTPSQRA EREAARSGPE GTLSPTPNPS TTTGSPLEDS PTVVPKSTTF LKNIRQFIMP
550 560 570 580 590 600
VVSARSSRVI KTPRRFMDED PPKPPKVEAS IVRPPVATSP PAPQEPVPVS SPPRVPTPPS
610 620 630 640 650 660
TPVPLPEKRR SILREPTFRW TSLTRELPPP PPAPPPAPSP PPAPATPSRR PLLLRAPQFT
670 680 690 700 710 720
PSEAHLKIYE SVLTPPPLGA LETPEPELPP ADDSPAEPEP RAVGRTNHLS LPRFVPVVTS
730 740 750 760 770 780
PVKVEVPPHG APALSEGQQL QLQQPPQALQ TQLLPQALPP QQPQAQPPPS PQHTPPLEKA
790 800 810 820 830 840
RVASLGSLPL SGVEEKMFSL LKRAKVQLFK IDQQQQQKVA ASMPLSPAVQ TEEAVGTVKQ
850 860 870 880 890 900
TPDRGCVRSE DESMEAKRDR ASGPESPLQG PRIKHVCRHA AVALGQARAM VPEDVPRLSA
910 920 930 940 950 960
LPLRDRQDLA TEDTSSASET ESVPSRSQRE KVESAGPGGD SEPTGSTGAL AHTPRRSLPS
970 980 990 1000 1010 1020
HHGKKMRMAR CGHCRGCLRV QDCGSCVNCL DKPKFGGPNT KKQCCVYRKC DKIEARKMER
1030 1040 1050 1060 1070 1080
LAKKGRTIVK TLLPWDSDES PEASPGPPGP RRGAGAGGSR EEVGATPGPE EQDSLLLQRK
1090 1100 1110 1120 1130 1140
SARRCVKQRP SYDVFEDSDD SEPGGPPAPR RRTPREHELP VLEPEEQSRP RKPTLQPVLQ
1150 1160 1170 1180 1190 1200
LKARRRLDKD ALAPGPFASF PNGWTGKQKS PDGVHRVRVD FKEDCDLENV WLMGGLSVLT
1210 1220 1230 1240 1250 1260
SVPGGPPMVC LLCASKGLHE LVFCQVCCDP FHPFCLEEAE RPSPQHRDTW CCRRCKFCHV
1270 1280 1290 1300 1310 1320
CGRKGRGSKH LLECERCRHA YHPACLGPSY PTRATRRRRH WICSACVRCK SCGATPGKNW
1330 1340 1350 1360 1370 1380
DVEWSGDYSL CPRCTELYEK GNYCPICTRC YEDNDYESKM MQCAQCDHWV HAKCEGLSDE
1390 1400 1410 1420 1430 1440
DYEILSGLPD SVLYTCGPCA GATQPRWREA LSGALQGGLR QVLQGLLSSK VAGPLLLCTQ
1450 1460 1470 1480 1490 1500
CGQDGKQLHP GPCDLQAVGK RFEEGLYKSV HSFMEDVVAI LMRHSEEGET PERRAGSQMK
1510 1520 1530 1540 1550 1560
GLLLKLLESA FCWFDAHDPK YWRRSTRLPN GVLPNAVLPP SLDHVYAQWR QQESETPESG
1570 1580 1590 1600 1610 1620
QPPGDPSAAF QSKDPAAFSH LDDPRQCALC LKYGDADSKE AGRLLYIGQN EWTHVNCAIW
1630 1640 1650 1660 1670 1680
SAEVFEENDG SLKNVHAAVA RGRQMRCELC LKPGATVGCC LSSCLSNFHF MCARASYCIF
1690 1700 1710 1720 1730 1740
QDDKKVFCQK HTDLLDGKEI VTPDGFDVLR RVYVDFEGIN FKRKFLTGLE PDVINVLIGS
1750 1760 1770 1780 1790 1800
IRINSLGTLS DLSDCEGRLF PIGYQCSRLY WSTVDARRRC WYRCRILEYR PWGPREEPVH
1810 1820 1830 1840 1850 1860
LEAAEENQTI VHSPTPSSDT DSLIPGDPVH HSPIQNLDPP LRTDSSNGPP PTPRSFSGAR
1870 1880 1890 1900 1910 1920
IKVPNYSPSR RPLGGVSFGP LPSPGSPSSL THHIPTVGDS DFPAPPRRSR RPSPLATRPP
1930 1940 1950 1960 1970 1980
PSRRTSSPLR TSPQLRVPLS TSVTALTPTS GELAPPDLAP SPLPPSEDLG PDFEDMEVVS
1990 2000 2010 2020 2030 2040
GLSAADLDFA ASLLGTEPFQ EEIVAAGAVG SSQGGPGDSS EEEASPTTHY VHFPVTVVSG
2050 2060 2070 2080 2090 2100
PALAPSSLAG APRIEQLDGV DDGTDSEAEA VQQPRGQGTP PSGPGVGRGG VLGAAGDRAQ
2110 2120 2130 2140 2150 2160
PPEDLPSEIV DFVLKNLGGP GEGAAGPRED SLPSAPPLAN GSQPPQSLST SPADPTRTFA
2170 2180 2190 2200 2210 2220
WLPGAPGVRV LSLGPAPEPP KPATSKIILV NKLGQVFVKM AGEGEPVAPP VKQPPLPPII
2230 2240 2250 2260 2270 2280
PPTAPTSWTL PPGPLLSVLP VVGVGVVRPA PPPPPPPLTL VFSSGPPSPP RQAIRVKRVS
2290 2300 2310 2320 2330 2340
TFSGRSPPVP PPNKTPRLDE DGESLEDAHH VPGISGSGFS RVRMKTPTVR GVLDLNNPGE
2350 2360 2370 2380 2390 2400
QPEEESPGRP QDRCPLLPLA EAPSQALDGS SDLLFESQWH HYSAGEASSS EEEPPSPEDK
2410 2420 2430 2440 2450 2460
ENQVPKRVGP HLRFEISSDD GFSVEAESLE VAWRTLIEKV QEARGHARLR HLSFSGMSGA
2470 2480 2490 2500 2510 2520
RLLGIHHDAV IFLAEQLPGA QRCQHYKFRY HQQGEGQEEP PLNPHGAARA EVYLRKCTFD
2530 2540 2550 2560 2570 2580
MFNFLASQHR VLPEGATCDE EEDEVQLRST RRATSLELPM AMRFRHLKKT SKEAVGVYRS
2590 2600 2610 2620 2630 2640
AIHGRGLFCK RNIDAGEMVI EYSGIVIRSV LTDKREKFYD GKGIGCYMFR MDDFDVVDAT
2650 2660 2670 2680 2690 2700
MHGNAARFIN HSCEPNCFSR VIHVEGQKHI VIFALRRILR GEELTYDYKF PIEDASNKLP
2710
CNCGAKRCRR FLN
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O08550 in FASTA format |
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