NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 43629 / JCM 7656 / NCTC 11639 / UA802;
DOI=10.1016/S0378-1119(97)00550-7; PubMed=9434188 [NCBI, ExPASy, EBI, Israel, Japan]
Ge Z., Jiang Q., Kalisiak M.S., Taylor D.E.;
"Cloning and functional characterization of Helicobacter pylori fumarate reductase operon comprising three structural genes coding for subunits C, A and B.";
Gene 204:227-234(1997).

[2]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700392 / 26695;
DOI=10.1038/41483; PubMed=9252185 [NCBI, ExPASy, EBI, Israel, Japan]
Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A., Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N., Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A., McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D., Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S., Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
"The complete genome sequence of the gastric pathogen Helicobacter pylori.";
Nature 388:539-547(1997).

Comments

CATALYTIC ACTIVITY: Succinate + acceptor = fumarate + reduced acceptor.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
SUBUNIT: Part of an enzyme complex containing three subunits: a flavoprotein, an iron-sulfur, and cytochrome b-556 (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U78101; AAC46065.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000511; AAD07258.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

G64543; G64543.

RefSeq

NP_206990.1; -.

3D structure databases

HSSP

P17596; 1QLA. [HSSP ENTRY / PDB]

SMR

O06914; 6-241.

ModBase

O06914.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
PF00037; Fer4; 1.
Pfam graphical view of domain structure.

PRINTS

PR00353; 4FE4SFRDOXIN.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

O06914.

Genome annotation databases

GeneID

899155; -.

GenomeReviews

AE000511_GR; HP_0191.

KEGG

hpy:HP0191; -.

NMPDR

fig|85962.1.peg.188; -.

TIGR

HP_0191; -.

Phylogenomic databases

HOGENOM

O06914; -.

Other

ProtoNet

O06914.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Metal-binding; Oxidoreductase; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 245`	`245`	`Fumarate reductase iron-sulfur subunit.`	`PRO_0000158703`
`DOMAIN`	`17 98`	`82`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`145 174`	`30`	`4Fe-4S ferredoxin-type.`
`METAL`	`60 60`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`65 65`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`68 68`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`80 80`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`154 154`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`157 157`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`160 160`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`164 164`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`211 211`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`217 217`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`221 221`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`CONFLICT`	`140 140`		`V -> I (in Ref. 1; AAC46065).`
`CONFLICT`	`194 194`		`N -> S (in Ref. 1; AAC46065).`

Sequence information

Length: 245 AA [This is the length of the unprocessed precursor]

Molecular weight: 27652 Da [This is the MW of the unprocessed precursor]

CRC64: D54447471FB4C499 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDNERTIVV RVLKFDPQSA VSKPHFKEYQ LKETPSMTLF IALNLIREHQ DPDLSFDFVC 

        70         80         90        100        110        120 
RAGICGSCAM MVNGRPRLAC KTLTSSFESG VITLMPMPSF TLIKDLSVNT GDWFLDMTKR 

       130        140        150        160        170        180 
VESWAHSKEE VDITRPEKRV EPDEAQEVFE LDRCIECGCC IASCGTKLMR PNFIGAAGMN 

       190        200        210        220        230        240 
RAMRFMIDSH DERNDDDFYE LVGDDDGVFG CMSLIACHDT CPKELPLQSS IATLRNRMLK 


VGKSR

O06914 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools