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UniProtKB/Swiss-Prot entry O04046


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GGPP2_ARATH
Primary accession number O04046
Secondary accession numbers Q38917 Q7DN59
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on November 1, 1998 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name Geranylgeranyl pyrophosphate synthetase 2 [Precursor]
Synonyms GGPP synthetase 2
GGPS2
Includes Dimethylallyltranstransferase
     (EC 2.5.1.1)
Geranyltranstransferase
     (EC 2.5.1.10)
Farnesyltranstransferase
     (EC 2.5.1.29)
Gene name
Name: GGPP2
Synonyms: GGPP5
OrderedLocusNames: At2g23800
ORFNames: F27L4.2
From
Arabidopsis thaliana (Mouse-ear cress) [TaxID: 3702] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Landsberg erecta;
TISSUE=Flower;
Scolnik P.A., Bartley G.E.;
"Two more members of an Arabidopsis geranylgeranyl pyrophosphate synthase gene family.";
(er) Plant Gene Register PGR96-014.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
DOI=10.1038/45471; PubMed=10617197 [NCBI, ExPASy, EBI, Israel, Japan]
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
Nature 402:761-768(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1088305; PubMed=14593172 [NCBI, ExPASy, EBI, Israel, Japan]
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis genome.";
Science 302:842-846(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
DOI=10.1126/science.1071006; PubMed=11910074 [NCBI, ExPASy, EBI, Israel, Japan]
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-376.
PubMed=9150607 [NCBI, ExPASy, EBI, Israel, Japan]
Zhu X.F., Suzuki K., Okada K., Tanaka K., Nakagawa T., Kawamukai M., Matsuda K.;
"Cloning and functional expression of a novel geranylgeranyl pyrophosphate synthase gene from Arabidopsis thaliana in Escherichia coli.";
Plant Cell Physiol. 38:357-361(1997).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 4-376, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
DOI=10.1104/pp.122.4.1045; PubMed=10759500 [NCBI, ExPASy, EBI, Israel, Japan]
Okada K., Saito T., Nakagawa T., Kawamukai M., Kamiya Y.;
"Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis.";
Plant Physiol. 122:1045-1056(2000).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U44876; AAB67730.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC004482; AAC17083.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT005328; AAO63392.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK117954; BAC42592.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY087521; AAM65063.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
D85029; BAA19583.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S71230; S71230.
T02429; T02429.
RefSeq NP_179960.1; -.
UniGene At.1550
3D structure databases
SMR O04046; 86-371.
ModBase O04046.
Enzyme and pathway databases
BioCyc MetaCyc:AT2G23800-MON; -.
Organism-specific databases
TAIR At2g23800; -.
Gene expression databases
ArrayExpress O04046; -.
GermOnline AT2G23800; Arabidopsis thaliana.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR000092; Polyprenyl_synt.
IPR017446; Polyprenyl_synth-rel.
IPR008949; Terpenoid_synth.
Graphical view of domain structure.
Gene3D G3DSA:1.10.600.10; Terpenoid_synth; 1.
PANTHER PTHR12001; Polyprenyl_synt; 1.
Pfam PF00348; polyprenyl_synt; 1.
Pfam graphical view of domain structure.
PROSITE PS00723; POLYPRENYL_SYNTHET_1; 1.
PS00444; POLYPRENYL_SYNTHET_2; 1.
BLOCKS O04046.
Genome annotation databases
GeneID 816912; -.
GenomeReviews CT485783_GR; AT2G23800.
KEGG ath:AT2G23800; -.
NMPDR fig|3702.1.peg.9405; -.
Other
ProtoNet O04046.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carotenoid biosynthesis; Complete proteome; Endoplasmic reticulum; Isoprene biosynthesis; Membrane; Multifunctional enzyme; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    24  24     Potential. 
CHAIN   25   376  352     Geranylgeranyl pyrophosphate synthetase 2. PRO_0000045402
TRANSMEM   188   208  21     Potential. 
COMPBIAS   60    72  13     Poly-Glu. 
CONFLICT   146   147        AM -> TI (in Ref. 1; AAB67730). 
CONFLICT   182   182        H -> D (in Ref. 1; AAB67730). 
Sequence information
Length: 376 AA [This is the length of the unprocessed precursor] Molecular weight: 41339 Da [This is the MW of the unprocessed precursor] CRC64: 1B643EC4086BD43B [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEPQILFLYL SLFILSLNFF FTNLKPRLVR LFQPSLESRV KTALLSRKEV AAFLDSPIVE 

        70         80         90        100        110        120 
DEEGEEREEE EEGGIVSNAN FTFEFDPYMM SKAESVNKAL EEAIPVGEPL KIHEAMRYAI 

       130        140        150        160        170        180 
LAAGKRVRPI LCLASCELVG GQENAAMPAA CAVEMIHTMS LIKDDLPCMD NDDLRRGKPT 

       190        200        210        220        230        240 
THKVYGEGVA ILSGGALLSL AFEHMTTAEI SSERMVWAVR ELARSIGTRG LVAGQAMDIS 

       250        260        270        280        290        300 
SEGLDLNEVG LEHLEFIHVH KTAVLLETAA VLGAIIGGGS DEEIESVRKF ARCIGLLFQV 

       310        320        330        340        350        360 
VDDILDETKS SEELGKTAGK DQLAGKLTYP KLIGLEKSKE FVKRLTKDAR QHLQGFSSEK 

       370 
VAPLVALTTF IANRNK 

O04046 in FASTA format

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