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- FUNCTION: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity).
- CATALYTIC ACTIVITY: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate.
- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
- PATHWAY: Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate: step 1/3.
- SUBUNIT: Homohexamer formed of two homotrimers in a head to head fashion (By similarity).
- INTERACTION:
Self; NbExp=2; IntAct=EBI-312091, EBI-312091;
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
| Name | a |
| Isoform ID | O02058-1 |
| Note: No experimental confirmation available. |
| This is the isoform sequence displayed in this entry. |
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| Name | b |
| Isoform ID | O02058-2 |
| Note: No experimental confirmation available. |
| Features which should be applied to build the isoform sequence: VSP_019291. |
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- MISCELLANEOUS: The active site is at the interface between 2 subunits. The proton acceptor Cys is on one subunit, and the charge relay system is on the other subunit.
- SIMILARITY: Belongs to the PTPS family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 140 AA [This is the length of the unprocessed precursor] |
Molecular weight: 16046 Da [This is the MW of the unprocessed precursor] |
CRC64: 7A677CE73A95882C [This is a checksum on the sequence] |
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10 20 30 40 50 60
MFRMPIVTME RVDSFSAAHR LHSEKLSDAE NKETFGKCNN SNGHGHNYVW KVKLRGEVDP
70 80 90 100 110 120
TSGMVYDLAK LKKEMSLVLD TVDHRNLDKD VEFFKTTVST SENVAIYMFE KLKSVMSNPS
130 140
VLYKVTIEET PKNIFTYKGC
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O02058 in FASTA format |
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