[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1038/sj.onc.1200986; PubMed=9135077 [NCBI, ExPASy, EBI, Israel, Japan]
Jay P.,
Berge-Lefranc J.-L.,
Marsollier C.,
Mejean C.,
Taviaux S.,
Berta P.;
"The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p.";
Oncogene 14:1753-1757(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9536281 [NCBI, ExPASy, EBI, Israel, Japan]
Martinerie C.,
Viegas-Pequignot E.,
Nguyen V.C.,
Perbal B.;
"Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.";
Mol. Pathol. 50:310-316(1997).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.M003053200; PubMed=10852911 [NCBI, ExPASy, EBI, Israel, Japan]
Albrecht C.,
von Der Kammer H.,
Mayhaus M.,
Klaudiny J.,
Schweizer M.,
Nitsch R.M.;
"Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61.";
J. Biol. Chem. 275:28929-28936(2000).
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[4]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
Kolesnikova T.V.,
Lau L.F.;
"Human growth-factor inducible gene product CYR61, complete sequence.";
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [MRNA].
Bi A.B.,
Yu L.;
"Cloning of HumCyr61 gene expressing down-regulatedly in rhabdomyosarcoma.";
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [MRNA].
Schuetze N.,
Lechner A.,
Groll C.,
Koehrle J.,
Jakob F.;
"Regulation of hCYR61 by vitamin D, serum and cytokines in fetal human osteoblasts.";
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
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[7]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1159/000048200; PubMed=11810026 [NCBI, ExPASy, EBI, Israel, Japan]
Leng E.,
Malcolm T.,
Tai G.,
Estable M.,
Sadowski I.;
"Organization and expression of the Cyr61 gene in normal human fibroblasts.";
J. Biomed. Sci. 9:59-67(2002).
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[8]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT TRP-334.
NIEHS SNPs program;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
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[9]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, Placenta, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[10]
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FUNCTION IN WOUND HEALING.
DOI=10.1074/jbc.M107666200; PubMed=11584015 [NCBI, ExPASy, EBI, Israel, Japan]
Chen C.-C.,
Mo F.-E.,
Lau L.F.;
"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts.";
J. Biol. Chem. 276:47329-47337(2001).
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[11]
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INTERACTION WITH INTEGRIN ALPHA-V/BETA-3.
DOI=10.1074/jbc.273.5.3090; PubMed=9446626 [NCBI, ExPASy, EBI, Israel, Japan]
Kireeva M.L.,
Lam S.C.,
Lau L.F.;
"Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.";
J. Biol. Chem. 273:3090-3096(1998).
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[12]
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INTERACTION WITH INTEGRIN ALPHA-IIB/BETA-3.
DOI=10.1074/jbc.274.34.24321; PubMed=10446209 [NCBI, ExPASy, EBI, Israel, Japan]
Jedsadayanmata A.,
Chen C.-C.,
Kireeva M.L.,
Lau L.F.,
Lam S.C.;
"Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3).";
J. Biol. Chem. 274:24321-24327(1999).
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[13]
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INTERACTION WITH INTEGRIN ALPHA-6/BETA-1.
DOI=10.1074/jbc.M003040200; PubMed=10821835 [NCBI, ExPASy, EBI, Israel, Japan]
Chen N.,
Chen C.-C.,
Lau L.F.;
"Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans.";
J. Biol. Chem. 275:24953-24961(2000).
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[14]
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INTERACTION WITH INTEGRIN ALPHA-V/BETA-6.
DOI=10.1074/jbc.M100978200; PubMed=11287419 [NCBI, ExPASy, EBI, Israel, Japan]
Grzeszkiewicz T.M.,
Kirschling D.J.,
Chen N.,
Lau L.F.;
"CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain.";
J. Biol. Chem. 276:21943-21950(2001).
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- FUNCTION: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
- SUBUNIT: Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.
- SUBCELLULAR LOCATION: Secreted.
- SIMILARITY: Belongs to the CCN family.
- SIMILARITY: Contains 1 CTCK (C-terminal cystine knot-like) domain.
- SIMILARITY: Contains 1 IGFBP N-terminal domain.
- SIMILARITY: Contains 1 TSP type-1 domain.
- SIMILARITY: Contains 1 VWFC domain.
- WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cyr61/";.
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