[1]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Uterine adenocarcinoma;
DOI=10.1038/11383; PubMed=10426319 [NCBI, ExPASy, EBI, Israel, Japan]
Nakashima M.,
Sonoda K.,
Watanabe T.;
"Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1.";
Nat. Med. 5:938-942(1999).
|
[2]
|
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Mammary cancer;
PubMed=9418891 [NCBI, ExPASy, EBI, Israel, Japan]
Watanabe T.,
Inoue S.,
Hiroi H.,
Orimo A.,
Kawashima H.,
Muramatsu M.;
"Isolation of estrogen-responsive genes with a CpG island library.";
Mol. Cell. Biol. 18:442-449(1998).
|
[3]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ebert L.,
Schick M.,
Neubert P.,
Schatten R.,
Henze S.,
Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
|
[4]
|
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, Lung, and Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
|
[5]
|
DISEASE.
DOI=10.1016/S0006-291X(02)00401-1; PubMed=12054692 [NCBI, ExPASy, EBI, Israel, Japan]
Rousseau J.,
Tetu B.,
Caron D.,
Malenfant P.,
Cattaruzzi P.,
Audette M.,
Doillon C.,
Tremblay J.P.,
Guerette B.;
"RCAS1 is associated with ductal breast cancer progression.";
Biochem. Biophys. Res. Commun. 293:1544-1549(2002).
|
[6]
|
DISEASE.
DOI=10.1159/000065065; PubMed=12138241 [NCBI, ExPASy, EBI, Israel, Japan]
Oizumi S.,
Yamazaki K.,
Nakashima M.,
Watanabe T.,
Hommura F.,
Ogura S.,
Nishimura M.,
Dosaka-Akita H.;
"RCAS1 expression: a potential prognostic marker for adenocarcinomas of the lung.";
Oncology 62:333-339(2002).
|
[7]
|
FUNCTION, AND SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M301361200; PubMed=12672804 [NCBI, ExPASy, EBI, Israel, Japan]
Engelsberg A.,
Hermosilla R.,
Karsten U.,
Schuelein R.,
Doerken B.,
Rehm A.;
"The Golgi protein RCAS1 controls cell surface expression of tumor-associated O-linked glycan antigens.";
J. Biol. Chem. 278:22998-23007(2003).
|
[8]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; THR-41 AND TYR-48, AND MASS SPECTROMETRY.
TISSUE=T-cell;
DOI=10.1021/ac035352d; PubMed=15144186 [NCBI, ExPASy, EBI, Israel, Japan]
Brill L.M.,
Salomon A.R.,
Ficarro S.B.,
Mukherji M.,
Stettler-Gill M.,
Peters E.C.;
"Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.";
Anal. Chem. 76:2763-2772(2004).
|
[9]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-94, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
|
[10]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
|
[11]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASS SPECTROMETRY.
DOI=10.1002/elps.200600782; PubMed=17487921 [NCBI, ExPASy, EBI, Israel, Japan]
Giorgianni F.,
Zhao Y.,
Desiderio D.M.,
Beranova-Giorgianni S.;
"Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.";
Electrophoresis 28:2027-2034(2007).
|
[12]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASS SPECTROMETRY.
DOI=10.2116/analsci.24.161; PubMed=18187866 [NCBI, ExPASy, EBI, Israel, Japan]
Imami K.,
Sugiyama N.,
Kyono Y.,
Tomita M.,
Ishihama Y.;
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Anal. Sci. 24:161-166(2008).
|
[13]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASS SPECTROMETRY.
TISSUE=Platelet;
DOI=10.1021/pr0704130; PubMed=18088087 [NCBI, ExPASy, EBI, Israel, Japan]
Zahedi R.P.,
Lewandrowski U.,
Wiesner J.,
Wortelkamp S.,
Moebius J.,
Schuetz C.,
Walter U.,
Gambaryan S.,
Sickmann A.;
"Phosphoproteome of resting human platelets.";
J. Proteome Res. 7:526-534(2008).
|
[14]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
|
[15]
|
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
|
|
- FUNCTION: May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.
- SUBUNIT: Homodimer.
- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type III membrane protein. Note=According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.
- TISSUE SPECIFICITY: Widely expressed. Expressed in ovary, testis, prostate, thymus, muscle and heart, but not in small intestine, colon, lymph nodes, or peripherical blood lymphocytes. The protein is not detected in any of the above organs.
- INDUCTION: By estrogen.
- DOMAIN: The coiled coil domain is necessary for the homodimerization.
- DISEASE: Defects in EBAG9 may be a cause of breast cancers and adenocarcinomas of the lung. It is present and overexpressed in many patients suffering from breast carcinomas, its level of expression correlates with tumor grade, suggesting that it may be involved in cancer immune escape. According to PubMed:12672804, it is however not directly a tumor-associated antigen, but it rather modulates surface expression of tumor-associated O-linked glycan Tn when it is overexpressed, suggesting that it contributes indirectly to the antigenicity of tumor cells.
- MISCELLANEOUS: May serve as a prognostic marker for cancers such as adenocarcinomas of the lung and breast cancers.
- CAUTION: It was initially reported to be a ligand for some putative receptor present on T-, B-, natural killer (NK) cells and various human cell lines. However, PubMed:12672804 showed that it does not bind any receptor.
- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/EBAG9ID40393ch8q23.html";.
|
ExPASy Home page
SIB Switzerland
