[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2), VARIANTS MEN1 ARG-22; LYS-119 DEL; GLU-368 DEL AND ARG-441, AND VARIANT GLN-176. TISSUE=Leukocyte; DOI=10.1126/science.276.5311.404; PubMed=9103196 [NCBI, ExPASy, EBI, Israel, Japan] Chandrasekharappa S.C., Guru S.C., Manickam P., Olufemi S.-E., Collins F.S., Emmert-Buck M.R., Debelenko L.V., Zhuang Z., Lubensky I.A., Liotta L.A., Crabtree J.S., Wang Y., Roe B.A., Weisemann J., Boguski M.S., Agarwal S.K., Kester M.B., Kim Y.S., Heppner C., Dong Q., Spiegel A.M., Burns A.L., Marx S.J.; "Positional cloning of the gene for multiple endocrine neoplasia-type 1."; Science 276:404-407(1997).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). TISSUE=Placenta; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[3]	FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH FANCD2. PubMed=12874027 [NCBI, ExPASy, EBI, Israel, Japan] Jin S., Mao H., Schnepp R.W., Sykes S.M., Silva A.C., D'Andrea A.D., Hua X.; "Menin associates with FANCD2, a protein involved in repair of DNA damage."; Cancer Res. 63:4204-4210(2003).
[4]	INTERACTION WITH DBF4. DOI=10.1158/0008-5472.CAN-04-0724; PubMed=15374998 [NCBI, ExPASy, EBI, Israel, Japan] Schnepp R.W., Hou Z., Wang H., Petersen C., Silva A., Masai H., Hua X.; "Functional interaction between tumor suppressor menin and activator of S-phase kinase."; Cancer Res. 64:6791-6796(2004).
[5]	IDENTIFICATION IN THE MLL-LIKE COMPLEX. DOI=10.1128/MCB.24.13.5639-5649.2004; PubMed=15199122 [NCBI, ExPASy, EBI, Israel, Japan] Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., Cleary M.L.; "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."; Mol. Cell. Biol. 24:5639-5649(2004).
[6]	IDENTIFICATION IN THE MLL-LIKE COMPLEX. DOI=10.1074/jbc.M701574200; PubMed=17500065 [NCBI, ExPASy, EBI, Israel, Japan] Cho Y.-W., Hong T., Hong S., Guo H., Yu H., Kim D., Guszczynski T., Dressler G.R., Copeland T.D., Kalkum M., Ge K.; "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."; J. Biol. Chem. 282:20395-20406(2007).
[7]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, AND MASS SPECTROMETRY. DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan] Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."; Science 316:1160-1166(2007).
[8]	PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-599, AND MASS SPECTROMETRY. DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan] Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.; "A quantitative atlas of mitotic phosphorylation."; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[9]	VARIANTS MEN1. DOI=10.1093/hmg/6.7.1169; PubMed=9215689 [NCBI, ExPASy, EBI, Israel, Japan] Agarwal S.K., Kester M.B., Debelenko L.V., Heppner C., Emmert-Buck M.R., Skarulis M.C., Doppman J.L., Kim Y.S., Lubensky I.A., Zhuang Z., Green J.S., Guru S.C., Manickam P., Olufemi S.E., Liotta L.A., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Burns A.L., Marx S.J.; "Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states."; Hum. Mol. Genet. 6:1169-1175(1997).
[10]	VARIANT MEN1 SER-188, AND VARIANT GLN-176. DOI=10.1093/hmg/6.7.1177; PubMed=9215690 [NCBI, ExPASy, EBI, Israel, Japan] The european consortium on MEN1; Lemmens I., Van de Ven W.J.M., Kas K., Zhang C.X., Giraud S., Wautot V., Buisson N., De Witte K., Salandre J., Lenoir G., Pugeat M., Calender A., Parente F., Quincey D., Gaudray P., De Wit M.J., Lips C.J.M., Hoeppener J.W.M., Khodaei S., Grant A.L., Weber G., Kytoelae S., Teh B.T., Farnebo F., Phelan C., Hayward N., Larsson C., Pannett A.A.J., Forbes S.A., Basset J.H.D., Thakker R.V.; "Identification of the multiple endocrine neoplasia type 1 (MEN1) gene."; Hum. Mol. Genet. 6:1177-1183(1997).
[11]	VARIANT PARATHYROID ADENOMA LYS-26. DOI=10.1038/ng0897-375; PubMed=9241276 [NCBI, ExPASy, EBI, Israel, Japan] Heppner C., Kester M.B., Agarwal S.K., Debelenko L.V., Emmert-Buck M.R., Guru S.C., Manickam P., Olufemi S.-E., Skarulis M.C., Doppman J.L., Alexander R.H., Kim Y.S., Saggar S.K., Lubensky I.A., Zhuang Z., Liotta L.A., Chandrasekharappa S.C., Collins F.S., Spiegel A.M., Burns A.L., Marx S.J.; "Somatic mutation of the MEN1 gene in parathyroid tumours."; Nat. Genet. 16:375-378(1997).
[12]	VARIANTS MEN1 ASP-42; PRO-165; ASP-169; SER-188 AND GLU-289. DOI=10.1086/301729; PubMed=9463336 [NCBI, ExPASy, EBI, Israel, Japan] Bassett J.H.D., Forbes S.A., Pannett A.A.J., Lloyd S.E., Christie P.T., Wooding C., Harding B., Besser G.M., Edwards C.R., Monson J.P., Sampson J., Wass J.A.H., Wheeler M.H., Thakker R.V.; "Characterization of mutations in patients with multiple endocrine neoplasia type 1."; Am. J. Hum. Genet. 62:232-244(1998).
[13]	VARIANTS MEN1. DOI=10.1086/301953; PubMed=9683585 [NCBI, ExPASy, EBI, Israel, Japan] Giraud S., Zhang C.X., Serova-Sinilnikova O., Wautot V., Salandre J., Buisson N., Waterlot C., Bauters C., Porchet N., Aubert J.-P., Emy P., Cadiot G., Delemer B., Chabre O., Niccoli P., Leprat F., Duron F., Emperauger B., Cougard P., Goudet P., Sarfati E., Riou J.-P., Guichard S., Rodier M., Meyrier A., Caron P., Vantyghem M.-C., Assayag M., Peix J.-L., Pugeat M., Rohmer V., Vallotton M., Lenoir G., Gaudray P., Proye C., Conte-Devolx B., Chanson P., Shugart Y.Y., Goldgar D., Murat A., Calender A.; "Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders."; Am. J. Hum. Genet. 63:455-467(1998).
[14]	VARIANT FIHP LYS-260. DOI=10.1086/302097; PubMed=9792884 [NCBI, ExPASy, EBI, Israel, Japan] Teh B.T., Esapa C.T., Houlston R., Grandell U., Farnebo F., Nordenskjoeld M., Pearce C.J., Carmichael D., Larsson C., Harris P.E.; "A family with isolated hyperparathyroidism segregating a missense MEN1 mutation and showing loss of the wild-type alleles in the parathyroid tumors."; Am. J. Hum. Genet. 63:1544-1549(1998).
[15]	VARIANT FIHP GLU-189. DOI=10.1002/(SICI)1096-8628(19981116)80:3<221::AID-AJMG8>3.0.CO;2-1; PubMed=9843042 [NCBI, ExPASy, EBI, Israel, Japan] Fujimori M., Shirahama S., Sakurai A., Hashizume K., Hama Y., Ito K., Shingu K., Kobayashi S., Amano J., Fukushima Y.; "Novel V184E MEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism."; Am. J. Med. Genet. 80:221-222(1998).
[16]	VARIANTS MEN1 LYS-26 AND PRO-173. DOI=10.1530/eje.0.1390416; PubMed=9820618 [NCBI, ExPASy, EBI, Israel, Japan] Bartsch D., Kopp I., Bergenfelz A., Rieder H., Muench K., Jaeger K., Deiss Y., Schudy A., Barth P., Arnold R., Rothmund M., Simon B.; "MEN1 gene mutations in 12 MEN1 families and their associated tumors."; Eur. J. Endocrinol. 139:416-420(1998).
[17]	VARIANTS MEN1. DOI=10.1002/(SICI)1098-1004(1998)12:2<75::AID-HUMU1>3.0.CO;2-T; PubMed=9671267 [NCBI, ExPASy, EBI, Israel, Japan] Agarwal S.K., Debelenko L.V., Kester M.B., Guru S.C., Manickam P., Olufemi S.-E., Skarulis M.C., Heppner C., Crabtree J.S., Lubensky I.A., Zhuang Z., Kim Y.S., Chandrasekharappa S.C., Collins F.S., Liotta L.A., Spiegel A.M., Burns A.L., Emmert-Buck M.R., Marx S.J.; "Analysis of recurrent germline mutations in the MEN1 gene encountered in apparently unrelated families."; Hum. Mutat. 12:75-82(1998).
[18]	VARIANT MEN1 ARG-432. PubMed=10660339 [NCBI, ExPASy, EBI, Israel, Japan] Cote G.J., Lee J.E., Evans D.B., Huang E., Schultz P.N., Dang G.T., Qiu H., Shetelbine S., Sellin R.V., Gagel R.F.; "Five novel mutations in the familial multiple endocrine neoplasia type 1 (MEN1) gene."; Hum. Mutat. 12:219-219(1998).
[19]	VARIANT MEN1 LEU-325, AND VARIANT THR-546. DOI=10.1210/jc.83.3.960; PubMed=9506756 [NCBI, ExPASy, EBI, Israel, Japan] Tanaka C., Yoshimoto K., Yamada S., Nishioka H., Ii S., Moritani M., Yamaoka T., Itakura M.; "Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese."; J. Clin. Endocrinol. Metab. 83:960-965(1998).
[20]	VARIANT MEN1 ASN-423, AND VARIANTS GLN-176 AND THR-546. DOI=10.1210/jc.83.8.2621; PubMed=9709921 [NCBI, ExPASy, EBI, Israel, Japan] Teh B.T., Kytoelae S., Farnebo F., Bergman L., Wong F.K., Weber G., Hayward N., Larsson C., Skogseid B., Beckers A., Phelan C., Edwards M., Epstein M., Alford F., Hurley D., Grimmond S., Silins G., Walters M., Stewart C., Cardinal J., Khodaei S., Parente F., Tranebjaerg L., Jorde R., Menon J., Khir A., Tan T.T., Chan S.P., Zaini A., Khalid B.A.K., Sandelin K., Thompson N., Brandi M.-L., Warth M., Stock J., Leisti J., Cameron D., Shepherd J.J., Oeberg K., Nordenskjoeld M., Salmela P.; "Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism."; J. Clin. Endocrinol. Metab. 83:2621-2626(1998).
[21]	VARIANT MEN1 SER-428. DOI=10.1210/jc.83.8.3004; PubMed=9709985 [NCBI, ExPASy, EBI, Israel, Japan] Mayr B., Brabant G., von zur Muehlen A.; "Menin mutations in MEN1 patients."; J. Clin. Endocrinol. Metab. 83:3004-3005(1998).
[22]	VARIANTS MEN1 ILE-135 AND LYS-364. DOI=10.1046/j.1523-1747.1998.00317.x; PubMed=9740255 [NCBI, ExPASy, EBI, Israel, Japan] Boeni R., Vortmeyer A.O., Pack S., Park W.-S., Burg G., Hofbauer G., Darling T., Liotta L., Zhuang Z.; "Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas."; J. Invest. Dermatol. 111:539-540(1998).
[23]	VARIANTS MEN1 LYS-119 DEL AND 171-GLN--LEU-173 DEL. DOI=10.1007/s100380050070; PubMed=9747036 [NCBI, ExPASy, EBI, Israel, Japan] Sakurai A., Shirahama S., Fujimori M., Katai M., Itakura Y., Kobayashi S., Amano J., Fukushima Y., Hashizume K.; "Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1."; J. Hum. Genet. 43:199-201(1998).
[24]	VARIANT MEN1 GLY-45. PubMed=9832038 [NCBI, ExPASy, EBI, Israel, Japan] Sato M., Matsubara S., Miyauchi A., Ohye H., Imachi H., Murao K., Takahara J.; "Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families."; J. Med. Genet. 35:915-919(1998).
[25]	VARIANT MEN1 ARG-139. DOI=10.1097/00019606-199912000-00005; PubMed=10617276 [NCBI, ExPASy, EBI, Israel, Japan] Martin-Campos J.M., Catasus L., Chico A., Mayoral C., Lagarda E., Gallart L., Mato E., Rodriguez-Espinosa J., Matias-Guiu X., De Leiva A., Blanco-Vaca F.; "Molecular pathology of multiple endocrine neoplasia type I: two novel germline mutations and updated classification of mutations affecting MEN1 gene."; Diagn. Mol. Pathol. 8:195-204(1999).
[26]	VARIANT MEN1 PRO-449. DOI=10.1530/eje.0.1400429; PubMed=10229909 [NCBI, ExPASy, EBI, Israel, Japan] Cetani F., Pardi E., Cianferotti L., Vignali E., Picone A., Miccoli P., Pinchera A., Marcocci C.; "A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1."; Eur. J. Endocrinol. 140:429-433(1999).
[27]	VARIANTS MEN1 ARG-188; ARG-230; TYR-246 AND PRO-258, AND VARIANT THR-546. DOI=10.1530/eje.0.1410475; PubMed=10576763 [NCBI, ExPASy, EBI, Israel, Japan] Hai N., Aoki N., Matsuda A., Mori T., Kosugi S.; "Germline MEN1 mutations in sixteen Japanese families with multiple endocrine neoplasia type 1 (MEN1)."; Eur. J. Endocrinol. 141:475-480(1999).
[28]	VARIANT ADRENAL ADENOMA SER-557. DOI=10.1007/s004390051152; PubMed=10647896 [NCBI, ExPASy, EBI, Israel, Japan] Schulte K.-M., Heinze M., Mengel M., Simon D., Scheuring S., Koehrer K., Roeher H.-D.; "MEN I gene mutations in sporadic adrenal adenomas."; Hum. Genet. 105:603-610(1999).
[29]	VARIANTS MEN1 TRP-39; TYR-177; ASP-184 AND PRO-269, VARIANT FIHP PRO-272, AND VARIANTS GLN-176 AND THR-546. DOI=10.1002/(SICI)1098-1004(1999)13:1<54::AID-HUMU6>3.0.CO;2-K; PubMed=9888389 [NCBI, ExPASy, EBI, Israel, Japan] Poncin J., Abs R., Velkeniers B., Bonduelle M., Abramowicz M., Legros J.-J., Verloes A., Meurisse M., van Gaal L., Verellen C., Koulischer L., Beckers A.; "Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases."; Hum. Mutat. 13:54-60(1999).
[30]	VARIANTS MEN1 ASP-161 AND ARG-246. DOI=10.1002/(SICI)1098-1004(1999)13:3<175::AID-HUMU1>3.3.CO;2-I; PubMed=10090472 [NCBI, ExPASy, EBI, Israel, Japan] Mutch M.G., Dilley W.G., Sanjurjo F., Debenedetti M.K., Doherty G.M., Wells S.A. Jr., Goodfellow P.J., Lairmore T.C.; "Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects."; Hum. Mutat. 13:175-185(1999).
[31]	VARIANT MEN1 PHE-160. PubMed=10534569 [NCBI, ExPASy, EBI, Israel, Japan] Engelbach M., Forst T., Hankeln T., Tratzky M., Heerdt S., Pfuetzner A., Kann P., Kunt T., Schneider S., Schmidt E.R., Beyer J.; "Germline mutations in the MEN1 gene: creation of a new splice acceptor site and insertion of 7 intron nucleotides into the mRNA."; Int. J. Mol. Med. 4:483-485(1999).
[32]	VARIANTS MEN1 LEU-234; ASP-358; SER-378 AND PRO-420. DOI=10.1054/bjoc.2000.1380; PubMed=10993647 [NCBI, ExPASy, EBI, Israel, Japan] Bergman L., Teh B.T., Cardinal J., Palmer J., Walters M., Shepherd J., Cameron D., Hayward N.; "Identification of MEN1 gene mutations in families with MEN 1 and related disorders."; Br. J. Cancer 83:1009-1014(2000).
[33]	VARIANTS PARATHYROID TUMOR ASP-161; ARG-188; TRP-258; ALA-279 AND PRO-289. PubMed=11034102 [NCBI, ExPASy, EBI, Israel, Japan] Uchino S., Noguchi S., Sato M., Yamashita H., Yamashita H., Watanabe S., Murakami T., Toda M., Ohshima A., Futata T., Mizukoshi T., Koike E., Takatsu K., Terao K., Wakiya S., Nagatomo M., Adachi M.; "Screening of the MEN1 gene and discovery of germ-line and somatic mutations in apparently sporadic parathyroid tumors."; Cancer Res. 60:5553-5557(2000).
[34]	VARIANTS MEN1 TRP-39; LYS-119 DEL; GLN-184; PRO-228; ARG-322; PRO-342; ASN-353; VAL-390 AND SER-549. DOI=10.1046/j.1365-2362.2000.00664.x; PubMed=10849016 [NCBI, ExPASy, EBI, Israel, Japan] Roijers J.F.M., de Wit M.J., van der Luijt R.B., Ploos van Amstel H.K., Hoeppener J.W.M., Lips C.J.M.; "Criteria for mutation analysis in MEN 1-suspected patients: MEN 1 case-finding."; Eur. J. Clin. Invest. 30:487-492(2000).
[35]	VARIANTS MEN1 LYS-45; MET-220 AND ARG-349. DOI=10.1530/eje.0.1420131; PubMed=10664520 [NCBI, ExPASy, EBI, Israel, Japan] Morelli A., Falchetti A., Martineti V., Becherini L., Mark M., Friedman E., Brandi M.L.; "MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1."; Eur. J. Endocrinol. 142:131-137(2000).
[36]	VARIANT FIHP ASP-310. DOI=10.1530/eje.0.1420138; PubMed=10664521 [NCBI, ExPASy, EBI, Israel, Japan] Honda M., Tsukada T., Tanaka H., Maruyama K., Yamaguchi K., Obara T., Yamaji T., Ishibashi M.; "A novel mutation of the MEN1 gene in a Japanese kindred with familial isolated primary hyperparathyroidism."; Eur. J. Endocrinol. 142:138-143(2000).
[37]	VARIANT MEN1 LYS-184. DOI=10.1002/1098-1004(200012)16:6<533::AID-HUMU22>3.0.CO;2-5; PubMed=11102994 [NCBI, ExPASy, EBI, Israel, Japan] Weinhaeusel A., Vierhapper H., Schlegl R., Wagner T., Muhr D., Scheuba C., Niederle B., Haas O.A.; "A novel mutation E179K of the MEN1 gene predisposes for multiple endocrine neoplasia-type 1 (MEN1)."; Hum. Mutat. 16:533-533(2000).
[38]	VARIANT FIHP PRO-265. DOI=10.1210/jc.85.1.165; PubMed=10634381 [NCBI, ExPASy, EBI, Israel, Japan] Kassem M., Kruse T.A., Wong F.K., Larsson C., Teh B.T.; "Familial isolated hyperparathyroidism as a variant of multiple endocrine neoplasia type 1 in a large Danish pedigree."; J. Clin. Endocrinol. Metab. 85:165-167(2000).
[39]	VARIANT MEN1 ASP-139. DOI=10.1210/jc.85.12.4776; PubMed=11134142 [NCBI, ExPASy, EBI, Israel, Japan] Stratakis C.A., Schussheim D.H., Freedman S.M., Keil M.F., Pack S.D., Agarwal S.K., Skarulis M.C., Weil R.J., Lubensky I.A., Zhuang Z., Oldfield E.H., Marx S.J.; "Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1."; J. Clin. Endocrinol. Metab. 85:4776-4780(2000).
[40]	VARIANT MEN1 PRO-419. DOI=10.1002/humu.12; PubMed=11241849 [NCBI, ExPASy, EBI, Israel, Japan] Asteria C., Faglia G., Roncoroni R., Borretta G., Ribotto P., Beck-Peccoz P.; "Identification of three novel menin mutations (c.741delGTCA, c.1348T>C, c.1785delA) in unrelated Italian families affected with multiple endocrine neoplasia type 1: additional information for mutational screening."; Hum. Mutat. 17:237-237(2001).
[41]	VARIANTS MEN1 TRP-39; ASP-42; LEU-98; PRO-165; THR-165; PHE-167; ASP-169; ARG-170; TYR-177; PRO-228; PHE-245; ARG-286; PRO-316; PRO-319; TYR-322; ARG-322; ASP-342; ARG-346; HIS-362; ASP-373; MET-377; ASN-423; CYS-532; ASN-560 AND ARG-560. DOI=10.1002/humu.10092; PubMed=12112656 [NCBI, ExPASy, EBI, Israel, Japan] Wautot V., Vercherat C., Lespinasse J., Chambe B., Lenoir G.M., Zhang C.X., Porchet N., Cordier M., Beroud C., Calender A.; "Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein."; Hum. Mutat. 20:35-47(2002).
[42]	VARIANT MEN1 LEU-GLN-266 INS. DOI=10.1093/jjco/hyf079; PubMed=12417605 [NCBI, ExPASy, EBI, Israel, Japan] Okamoto H., Tamada A., Hai N., Doi M., Uchimura I., Hirata Y., Kosugi S.; "A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism."; Jpn. J. Clin. Oncol. 32:368-370(2002).
[43]	VARIANTS MEN1 LYS-119 DEL; ILE-159; GLU-368 DEL AND ASN-423. DOI=10.1210/jc.87.6.2688; PubMed=12050235 [NCBI, ExPASy, EBI, Israel, Japan] Turner J.J.O., Leotlela P.D., Pannett A.A.J., Forbes S.A., Bassett J.H.D., Harding B., Christie P.T., Bowen-Jones D., Ellard S., Hattersley A., Jackson C.E., Pope R., Quarrell O.W., Trembath R., Thakker R.V.; "Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1."; J. Clin. Endocrinol. Metab. 87:2688-2693(2002).
[44]	VARIANT FIHP HIS-282. DOI=10.1007/s00268-002-6617-9; PubMed=12016470 [NCBI, ExPASy, EBI, Israel, Japan] Perrier N.D., Villablanca A., Larsson C., Wong M., Ituarte P., Teh B.T., Clark O.H.; "Genetic screening for MEN1 mutations in families presenting with familial primary hyperparathyroidism."; World J. Surg. 26:907-913(2002).
[45]	VARIANTS FIHP VAL-158 AND PRO-416. DOI=10.1046/j.1365-2265.2003.01765.x; PubMed=12699448 [NCBI, ExPASy, EBI, Israel, Japan] Pannett A.A.J., Kennedy A.M., Turner J.J.O., Forbes S.A., Cavaco B.M., Bassett J.H.D., Cianferotti L., Harding B., Shine B., Flinter F., Maidment C.G.H., Trembath R., Thakker R.V.; "Multiple endocrine neoplasia type 1 (MEN1) germline mutations in familial isolated primary hyperparathyroidism."; Clin. Endocrinol. (Oxf.) 58:639-646(2003).
[46]	VARIANT MEN1 PRO-330. DOI=10.1034/j.1399-0004.2003.00091.x; PubMed=12791038 [NCBI, ExPASy, EBI, Israel, Japan] Park J.-H., Kim I.-J., Kang H.C., Lee S.-H., Shin Y., Kim K.-H., Lim S.-B., Kang S.-B., Lee K.U., Kim S.Y., Lee M.-S., Lee M.-K., Park J.-H., Moon S.-D., Park J.-G.; "Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders."; Clin. Genet. 64:48-53(2003).
[47]	VARIANTS MEN1 ARG-170; PRO-228; PHE-246; ARG-286; PRO-316; TYR-322; ASN-423 AND SER-545. DOI=10.1002/elps.200390023; PubMed=12652570 [NCBI, ExPASy, EBI, Israel, Japan] Groupe d'etude des neoplasies emdocriniennes multiples; Crepin M., Escande F., Pigny P., Buisine M.-P., Calender A., Porchet N., Odou M.-F.; "Efficient mutation detection in MEN1 gene using a combination of single-strand conformation polymorphism (MDGA) and heteroduplex analysis."; Electrophoresis 24:26-33(2003).
[48]	VARIANT MEN1 PRO-347. PubMed=14686752 [NCBI, ExPASy, EBI, Israel, Japan] Ukita C., Yamaguchi M., Tanaka T., Shigeta H., Nishikawa M.; "A novel missense mutation of the MEN1 gene in a multiple endocrine neoplasia type 1 patient associated with carcinoid syndrome."; Intern. Med. 42:1112-1116(2003).
[49]	VARIANTS MEN1 LYS-45 AND PRO-139, AND VARIANTS GLN-176 AND THR-546. DOI=10.1136/jmg.40.5.e72; PubMed=12746426 [NCBI, ExPASy, EBI, Israel, Japan] Cebrian A., Ruiz-Llorente S., Cascon A., Pollan M., Diez J.J., Pico A., Telleria D., Benitez J., Robledo M.; "Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients."; J. Med. Genet. 40:E72-E72(2003).
[50]	VARIANTS MEN1 GLU-110 AND HIS-423. DOI=10.1111/j.1365-2265.2005.02219.x; PubMed=15730416 [NCBI, ExPASy, EBI, Israel, Japan] Jap T.-S., Chiu C.-Y., Won J.G.-S., Wu Y.-C., Chen H.-S.; "Novel mutations in the MEN1 gene in subjects with multiple endocrine neoplasia-1."; Clin. Endocrinol. (Oxf.) 62:336-342(2005).
[51]	VARIANTS MEN1 VAL-144; ASP-161; ASP-184; LYS-184; ARG-186; MET-220; ARG-264; ARG-325; TRP-360; TYR-426; CYS-441 AND ARG-441. DOI=10.1097/01.GIM.0000153663.62300.F8; PubMed=15714081 [NCBI, ExPASy, EBI, Israel, Japan] Klein R.D., Salih S., Bessoni J., Bale A.E.; "Clinical testing for multiple endocrine neoplasia type 1 in a DNA diagnostic laboratory."; Genet. Med. 7:131-138(2005).

Comments

FUNCTION: May be involved in DNA repair.
SUBUNIT: Interacts with FANCD2 and DBF4. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.
INTERACTION:
Q9H4W6:EBF3; NbExp=1; IntAct=EBI-592789, EBI-2111898;
Q9BXW9:FANCD2; NbExp=4; IntAct=EBI-592789, EBI-359343;
P35579:MYH9; NbExp=5; IntAct=EBI-592789, EBI-350338;
Q05982:Nme1 (xeno); NbExp=4; IntAct=EBI-592789, EBI-1165329;
Q9NS64:RPRM; NbExp=1; IntAct=EBI-592789, EBI-1052363;
SUBCELLULAR LOCATION: Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation.

ALTERNATIVE PRODUCTS: 3 named isoforms [FASTA] produced by alternative splicing.

Name	1
Synonyms	Long
Isoform ID	O00255-1
This is the isoform sequence displayed in this entry.

Name	2
Synonyms	Short
Isoform ID	O00255-2
Features which should be applied to build the isoform sequence: VSP_004323.

Name	3
Isoform ID	O00255-3
Features which should be applied to build the isoform sequence: VSP_004323, VSP_015854.

TISSUE SPECIFICITY: Ubiquitous.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE: Defects in MEN1 are the cause of familial multiple endocrine neoplasia type I (MEN1) [MIM:131100]; an autosomal dominant disorder characterized by tumors of the parathyroid glands, gastro-intestinal endocrine tissue, the anterior pituitary and other tissues. Cutaneous lesions and nervous-tissue tumors can exist. Prognosis in MEN1 patients is related to hormonal hypersecretion by tumors, such as hypergastrinemia causing severe peptic ulcer disease (Zollinger-Ellison syndrome, ZES), primary hyperparathyroidism, and acute forms of hyperinsulinemia.
DISEASE: Defects in MEN1 are the cause of familial isolated hyperparathyroidism (FIHP) [MIM:145000]; also known as hyperparathyroidism type 1 (HRPT1). FIHP is an autosomal dominant disorder characterized by hypercalcemia, elevated parathyroid hormone (PTH) levels, and uniglandular or multiglandular parathyroid tumors.
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MEN1ID148.html";.
WEB RESOURCE: Name=GeneReviews; URL="http://www.genetests.org/query?gene=MEN1";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U93236; AAC51228.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U93237; AAC51229.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U93237; AAC51230.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC002544; AAH02544.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

IPI

IPI00182106; -.
IPI00328838; -.
IPI00651636; -.

RefSeq

NP_000235.2; -.
NP_570711.1; -.
NP_570712.1; -.
NP_570713.1; -.
NP_570714.1; -.
NP_570715.1; -.
NP_570716.1; -.

UniGene

Hs.423348

3D structure databases

ModBase

O00255.

Protein-protein interaction databases

DIP

DIP:24236N; -.

IntAct

O00255; 11.

PTM databases

PhosphoSite

O00255; -.

Organism-specific databases

GC11M064327; -.

HIX0009771; -.

HGNC:7010; MEN1.

131100; gene+phenotype. [NCBI / EBI]
145000; phenotype. [NCBI / EBI]

Orphanet

99879; Hyperparathyroidism, familial, isolated (FIHPT).
2207; Hyperparathyroidism, primary, familial.
652; Multiple endocrine neoplasia type 1.
99877; Parathyroid adenoma.
913; Zollinger-Ellison syndrome.

PharmGKB

PA38241; -.

Gene expression databases

Bgee

O00255; -.

CleanEx

HS_MEN1; -.
HS_SCG2; -.

GermOnline

ENSG00000133895; Homo sapiens.

Ontologies

GO:0000785;	Cellular component: chromatin (inferred from direct assay from UniProtKB).
GO:0032154;	Cellular component: cleavage furrow (inferred from direct assay from UniProtKB).
GO:0005829;	Cellular component: cytosol (inferred from direct assay from UniProtKB).
GO:0035097;	Cellular component: histone methyltransferase complex (inferred from direct assay from MGI).
GO:0016363;	Cellular component: nuclear matrix (inferred from direct assay from UniProtKB).
GO:0005625;	Cellular component: soluble fraction (inferred from direct assay from UniProtKB).
GO:0003690;	Molecular function: double-stranded DNA binding (inferred from direct assay from UniProtKB).
GO:0000400;	Molecular function: four-way junction DNA binding (inferred from direct assay from UniProtKB).
GO:0047485;	Molecular function: protein N-terminus binding (inferred from physical interaction from UniProtKB).
GO:0070412;	Molecular function: R-SMAD binding (inferred from physical interaction from UniProtKB).
GO:0000403;	Molecular function: Y-form DNA binding (inferred from direct assay from UniProtKB).
GO:0006281;	Biological process: DNA repair (non-traceable author statement from UniProtKB).
GO:0000165;	Biological process: MAPKKK cascade (inferred from direct assay from UniProtKB).
GO:0008285;	Biological process: negative regulation of cell proliferation (inferred from direct assay from UniProtKB).
GO:0045736;	Biological process: negative regulation of cyclin-dependent protein kinase activity (inferred from mutant phenotype from UniProtKB).
GO:0046329;	Biological process: negative regulation of JNK cascade (inferred from direct assay from UniProtKB).
GO:0045668;	Biological process: negative regulation of osteoblast differentiation (inferred from genetic interaction from MGI).
GO:0001933;	Biological process: negative regulation of protein amino acid phosphorylation (inferred from direct assay from UniProtKB).
GO:0051974;	Biological process: negative regulation of telomerase activity (inferred from mutant phenotype from UniProtKB).
GO:0043433;	Biological process: negative regulation of transcription factor activity (inferred from direct assay from UniProtKB).
GO:0000122;	Biological process: negative regulation of transcription from RNA polymerase II promoter (inferred from direct assay from UniProtKB).
GO:0002076;	Biological process: osteoblast development (inferred from genetic interaction from MGI).
GO:0030511;	Biological process: positive regulation of transforming growth factor beta receptor signaling pathway (inferred from mutant phenotype from UniProtKB).
GO:0010332;	Biological process: response to gamma radiation (inferred from direct assay from UniProtKB).
GO:0009411;	Biological process: response to UV (inferred from direct assay from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR007747; Menin.
Graphical view of domain structure.

PANTHER

PTHR12693; Menin; 1.

Pfam

PF05053; Menin; 1.
Pfam graphical view of domain structure.

Proteomic databases

PRIDE

O00255; -.

Genome annotation databases

Ensembl

ENSG00000133895; Homo sapiens. [Contig view]

GeneID

4221; -.

KEGG

hsa:4221; -.

Phylogenomic databases

HOGENOM

O00255; -.

HOVERGEN

O00255; -.

Other

16643; -.

MEN1; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Disease mutation; Nucleus; Phosphoprotein; Polymorphism.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 615`	`615`	`Menin.`	`PRO_0000096411`
`REGION`	`219 395`	`177`	`Interaction with FANCD2.`
`MOD_RES`	`399 399`		`Phosphoserine.`
`MOD_RES`	`599 599`		`Phosphothreonine.`
`VAR_SEQ`	`149 153`		`Missing (in isoform 2 and isoform 3).`	`VSP_004323`
`VAR_SEQ`	`189 223`		`Missing (in isoform 3).`	`VSP_015854`
`VARIANT`	`12 12`	`1`	`P -> L (in MEN1).`	`VAR_005425`
`VARIANT`	`22 22`	`1`	`L -> R (in MEN1).`	`VAR_005426`
`VARIANT`	`26 26`	`1`	`E -> K (in parathyroid adenoma and MEN1; dbSNP:rs28931612 [NCBI]).`	`VAR_005427`
`VARIANT`	`39 39`	`1`	`L -> W (in MEN1).`	`VAR_005428`
`VARIANT`	`42 42`	`1`	`G -> D (in MEN1).`	`VAR_005429`
`VARIANT`	`45 45`	`1`	`E -> G (in MEN1).`	`VAR_005430`
`VARIANT`	`45 45`	`1`	`E -> K (in MEN1).`	`VAR_039587`
`VARIANT`	`98 98`	`1`	`R -> L (in MEN1).`	`VAR_039588`
`VARIANT`	`110 110`	`1`	`G -> E (in MEN1).`	`VAR_039589`
`VARIANT`	`119 119`	`1`	`Missing (in MEN1).`	`VAR_005431`
`VARIANT`	`135 135`	`1`	`K -> I (in MEN1).`	`VAR_005434`
`VARIANT`	`139 139`	`1`	`H -> D (in MEN1).`	`VAR_005432`
`VARIANT`	`139 139`	`1`	`H -> P (in MEN1).`	`VAR_039590`
`VARIANT`	`139 139`	`1`	`H -> R (in MEN1).`	`VAR_039591`
`VARIANT`	`139 139`	`1`	`H -> Y (in MEN1; familial and sporadic cases).`	`VAR_005433`
`VARIANT`	`144 144`	`1`	`F -> V (in MEN1).`	`VAR_005436`
`VARIANT`	`158 158`	`1`	`D -> V (in MEN1 and FIHP).`	`VAR_039592`
`VARIANT`	`159 159`	`1`	`S -> I (in MEN1).`	`VAR_039593`
`VARIANT`	`160 160`	`1`	`S -> F (in MEN1).`	`VAR_039594`
`VARIANT`	`161 161`	`1`	`G -> D (in MEN1 and parathyroid tumor).`	`VAR_008017`
`VARIANT`	`165 165`	`1`	`A -> P (in MEN1).`	`VAR_005437`
`VARIANT`	`165 165`	`1`	`A -> T (in MEN1).`	`VAR_039595`
`VARIANT`	`167 167`	`1`	`V -> F (in MEN1).`	`VAR_039596`
`VARIANT`	`169 169`	`1`	`A -> D (in MEN1).`	`VAR_005438`
`VARIANT`	`170 170`	`1`	`C -> R (in MEN1).`	`VAR_039597`
`VARIANT`	`171 173`	`3`	`Missing (in MEN1).`	`VAR_005439`
`VARIANT`	`173 173`	`1`	`L -> P (in MEN1).`	`VAR_039598`
`VARIANT`	`176 176`	`1`	`R -> Q (in dbSNP:rs607969 [NCBI]).`	`VAR_005440`
`VARIANT`	`177 177`	`1`	`D -> Y (in MEN1).`	`VAR_005441`
`VARIANT`	`181 181`	`1`	`A -> P (in MEN1).`	`VAR_005442`
`VARIANT`	`184 184`	`1`	`E -> D (in MEN1).`	`VAR_005443`
`VARIANT`	`184 184`	`1`	`E -> K (in MEN1).`	`VAR_039599`
`VARIANT`	`184 184`	`1`	`E -> Q (in MEN1).`	`VAR_039600`
`VARIANT`	`186 186`	`1`	`H -> R (in MEN1).`	`VAR_039601`
`VARIANT`	`188 188`	`1`	`W -> R (in MEN1 and parathyroid tumor).`	`VAR_039602`
`VARIANT`	`188 188`	`1`	`W -> S (in MEN1).`	`VAR_005444`
`VARIANT`	`189 189`	`1`	`V -> E (in FIHP).`	`VAR_005445`
`VARIANT`	`220 220`	`1`	`V -> M (in MEN1).`	`VAR_039603`
`VARIANT`	`228 228`	`1`	`L -> P (in MEN1).`	`VAR_005446`
`VARIANT`	`230 230`	`1`	`G -> R (in MEN1).`	`VAR_039604`
`VARIANT`	`234 234`	`1`	`R -> L (in MEN1).`	`VAR_039605`
`VARIANT`	`245 245`	`1`	`V -> F (in MEN1).`	`VAR_039606`
`VARIANT`	`246 246`	`1`	`C -> F (in MEN1).`	`VAR_039607`
`VARIANT`	`246 246`	`1`	`C -> R (in MEN1).`	`VAR_008018`
`VARIANT`	`246 246`	`1`	`C -> Y (in MEN1).`	`VAR_039608`
`VARIANT`	`247 247`	`1`	`A -> V (in MEN1).`	`VAR_005447`
`VARIANT`	`258 258`	`1`	`S -> P (in MEN1).`	`VAR_039609`
`VARIANT`	`258 258`	`1`	`S -> W (in parathyroid tumor).`	`VAR_039610`
`VARIANT`	`260 260`	`1`	`E -> K (in FIHP).`	`VAR_005448`
`VARIANT`	`264 264`	`1`	`L -> R (in MEN1).`	`VAR_039611`
`VARIANT`	`265 265`	`1`	`Q -> P (in FIHP).`	`VAR_039612`
`VARIANT`	`266 266`	`1`	`Q -> QLQ (in MEN1).`	`VAR_039613`
`VARIANT`	`269 269`	`1`	`L -> P (in MEN1).`	`VAR_005449`
`VARIANT`	`272 272`	`1`	`L -> P (in FIHP).`	`VAR_005450`
`VARIANT`	`279 279`	`1`	`E -> A (in parathyroid tumor).`	`VAR_039614`
`VARIANT`	`282 282`	`1`	`P -> H (in FIHP).`	`VAR_039615`
`VARIANT`	`286 286`	`1`	`G -> R (in MEN1).`	`VAR_039616`
`VARIANT`	`289 289`	`1`	`A -> E (in MEN1).`	`VAR_005451`
`VARIANT`	`289 289`	`1`	`A -> P (in parathyroid tumor).`	`VAR_039617`
`VARIANT`	`291 291`	`1`	`L -> P (in MEN1).`	`VAR_005452`
`VARIANT`	`310 310`	`1`	`G -> D (in FIHP).`	`VAR_039618`
`VARIANT`	`314 314`	`1`	`A -> P (in MEN1).`	`VAR_005453`
`VARIANT`	`316 316`	`1`	`T -> P (in MEN1).`	`VAR_039619`
`VARIANT`	`319 319`	`1`	`R -> P (in MEN1).`	`VAR_005454`
`VARIANT`	`322 322`	`1`	`H -> R (in MEN1).`	`VAR_039620`
`VARIANT`	`322 322`	`1`	`H -> Y (in MEN1).`	`VAR_039621`
`VARIANT`	`325 325`	`1`	`P -> L (in MEN1).`	`VAR_039622`
`VARIANT`	`325 325`	`1`	`P -> R (in MEN1).`	`VAR_039623`
`VARIANT`	`330 330`	`1`	`A -> P (in MEN1).`	`VAR_039624`
`VARIANT`	`342 342`	`1`	`A -> D (in MEN1; dbSNP:rs2071312 [NCBI]).`	`VAR_005455`
`VARIANT`	`342 342`	`1`	`A -> P (in MEN1).`	`VAR_039625`
`VARIANT`	`346 346`	`1`	`W -> R (in MEN1).`	`VAR_005456`
`VARIANT`	`347 347`	`1`	`A -> P (in MEN1).`	`VAR_039626`
`VARIANT`	`349 349`	`1`	`T -> R (in MEN1).`	`VAR_005457`
`VARIANT`	`353 353`	`1`	`I -> N (in MEN1).`	`VAR_039627`
`VARIANT`	`358 358`	`1`	`Y -> D (in MEN1).`	`VAR_039628`
`VARIANT`	`360 360`	`1`	`R -> W (in MEN1).`	`VAR_039629`
`VARIANT`	`362 362`	`1`	`D -> H (in MEN1).`	`VAR_039630`
`VARIANT`	`364 364`	`1`	`E -> K (in MEN1).`	`VAR_005458`
`VARIANT`	`368 368`	`1`	`Missing (in MEN1).`	`VAR_005459`
`VARIANT`	`373 373`	`1`	`A -> D (in MEN1).`	`VAR_005460`
`VARIANT`	`377 377`	`1`	`I -> M (in MEN1).`	`VAR_039631`
`VARIANT`	`378 378`	`1`	`P -> S (in MEN1).`	`VAR_039632`
`VARIANT`	`390 390`	`1`	`A -> V (in MEN1).`	`VAR_039633`
`VARIANT`	`416 416`	`1`	`A -> P (in MEN1 and FIHP).`	`VAR_039634`
`VARIANT`	`419 419`	`1`	`L -> P (in MEN1).`	`VAR_039635`
`VARIANT`	`420 420`	`1`	`R -> P (in MEN1).`	`VAR_039636`
`VARIANT`	`423 426`	`4`	`Missing (in MEN1).`	`VAR_005463`
`VARIANT`	`423 423`	`1`	`D -> H (in MEN1).`	`VAR_039637`
`VARIANT`	`423 423`	`1`	`D -> N (in MEN1).`	`VAR_005461`
`VARIANT`	`423 423`	`1`	`Missing (in MEN1).`	`VAR_005462`
`VARIANT`	`426 426`	`1`	`C -> Y (in MEN1).`	`VAR_039638`
`VARIANT`	`428 428`	`1`	`W -> S (in MEN1).`	`VAR_039639`
`VARIANT`	`432 432`	`1`	`S -> R (in MEN1).`	`VAR_039640`
`VARIANT`	`441 441`	`1`	`W -> C (in MEN1).`	`VAR_039641`
`VARIANT`	`441 441`	`1`	`W -> R (in MEN1).`	`VAR_005464`
`VARIANT`	`449 449`	`1`	`L -> P (in MEN1).`	`VAR_039642`
`VARIANT`	`452 452`	`1`	`F -> S (in MEN1; sporadic; with Zollinger-Ellison syndrome).`	`VAR_005465`
`VARIANT`	`532 532`	`1`	`R -> C (in MEN1).`	`VAR_039643`
`VARIANT`	`545 545`	`1`	`P -> S (in MEN1).`	`VAR_039644`
`VARIANT`	`546 546`	`1`	`A -> T (in dbSNP:rs2959656 [NCBI]).`	`VAR_005466`
`VARIANT`	`549 549`	`1`	`P -> S (in MEN1).`	`VAR_039645`
`VARIANT`	`557 557`	`1`	`T -> S (in adrenal adenoma; somatic).`	`VAR_039646`
`VARIANT`	`560 560`	`1`	`S -> N (in MEN1).`	`VAR_005467`
`VARIANT`	`560 560`	`1`	`S -> R (in MEN1).`	`VAR_039647`

Sequence information

Length: 615 AA [This is the length of the unprocessed precursor]

Molecular weight: 67993 Da [This is the MW of the unprocessed precursor]

CRC64: CDCE840EA5B71BC4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGLKAAQKTL FPLRSIDDVV RLFAAELGRE EPDLVLLSLV LGFVEHFLAV NRVIPTNVPE 

        70         80         90        100        110        120 
LTFQPSPAPD PPGGLTYFPV ADLSIIAALY ARFTAQIRGA VDLSLYPREG GVSSRELVKK 

       130        140        150        160        170        180 
VSDVIWNSLS RSYFKDRAHI QSLFSFITGW SPVGTKLDSS GVAFAVVGAC QALGLRDVHL 

       190        200        210        220        230        240 
ALSEDHAWVV FGPNGEQTAE VTWHGKGNED RRGQTVNAGV AERSWLYLKG SYMRCDRKME 

       250        260        270        280        290        300 
VAFMVCAINP SIDLHTDSLE LLQLQQKLLW LLYDLGHLER YPMALGNLAD LEELEPTPGR 

       310        320        330        340        350        360 
PDPLTLYHKG IASAKTYYRD EHIYPYMYLA GYHCRNRNVR EALQAWADTA TVIQDYNYCR 

       370        380        390        400        410        420 
EDEEIYKEFF EVANDVIPNL LKEAASLLEA GEERPGEQSQ GTQSQGSALQ DPECFAHLLR 

       430        440        450        460        470        480 
FYDGICKWEE GSPTPVLHVG WATFLVQSLG RFEGQVRQKV RIVSREAEAA EAEEPWGEEA 

       490        500        510        520        530        540 
REGRRRGPRR ESKPEEPPPP KKPALDKGLG TGQGAVSGPP RKPPGTVAGT ARGPEGGSTA 

       550        560        570        580        590        600 
QVPAPAASPP PEGPVLTFQS EKMKGMKELL VATKINSSAI KLQLTAQSQV QMKKQKVSTP 

       610 
SDYTLSFLKR QRKGL

O00255 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools