[1]
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NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.94.9.4440; PubMed=9114008 [NCBI, ExPASy, EBI, Israel, Japan]
Waldegger S.,
Barth P.,
Raber G.,
Lang F.;
"Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.";
Proc. Natl. Acad. Sci. U.S.A. 94:4440-4445(1997).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1006/geno.1998.5258; PubMed=9722955 [NCBI, ExPASy, EBI, Israel, Japan]
Waldegger S.,
Erdel M.,
Nagl U.O.,
Barth P.,
Raber G.,
Steuer S.,
Utermann G.,
Paulmichl M.,
Lang F.;
"Genomic organization and chromosomal localization of the human SGK protein kinase gene.";
Genomics 51:299-302(1998).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Hair follicle dermal papilla;
Kim M.K.,
Kim Y.H.,
Seo J.M.,
Lee H.M.,
Chung H.J.,
Sohn M.Y.,
Hwang S.Y.,
Im S.U.,
Jung E.J.,
Lee J.H.,
Kim J.C.;
"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags.";
Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02055; PubMed=14574404 [NCBI, ExPASy, EBI, Israel, Japan]
Mungall A.J.,
Palmer S.A.,
Sims S.K.,
Edwards C.A.,
Ashurst J.L.,
Wilming L.,
Jones M.C.,
Horton R.,
Hunt S.E.,
Scott C.E.,
Gilbert J.G.R.,
Clamp M.E.,
Bethel G.,
Milne S.,
Ainscough R.,
Almeida J.P.,
Ambrose K.D.,
Andrews T.D.,
Ashwell R.I.S., ![]()
Babbage A.K.,
Bagguley C.L.,
Bailey J.,
Banerjee R.,
Barker D.J.,
Barlow K.F.,
Bates K.,
Beare D.M.,
Beasley H.,
Beasley O.,
Bird C.P.,
Blakey S.E.,
Bray-Allen S.,
Brook J.,
Brown A.J.,
Brown J.Y.,
Burford D.C.,
Burrill W.,
Burton J.,
Carder C.,
Carter N.P.,
Chapman J.C.,
Clark S.Y.,
Clark G.,
Clee C.M.,
Clegg S.,
Cobley V.,
Collier R.E.,
Collins J.E.,
Colman L.K.,
Corby N.R.,
Coville G.J.,
Culley K.M.,
Dhami P.,
Davies J.,
Dunn M.,
Earthrowl M.E.,
Ellington A.E.,
Evans K.A.,
Faulkner L.,
Francis M.D.,
Frankish A.,
Frankland J.,
French L.,
Garner P.,
Garnett J.,
Ghori M.J.,
Gilby L.M.,
Gillson C.J.,
Glithero R.J.,
Grafham D.V.,
Grant M.,
Gribble S.,
Griffiths C.,
Griffiths M.N.D.,
Hall R.,
Halls K.S.,
Hammond S.,
Harley J.L.,
Hart E.A.,
Heath P.D.,
Heathcott R.,
Holmes S.J.,
Howden P.J.,
Howe K.L.,
Howell G.R.,
Huckle E.,
Humphray S.J.,
Humphries M.D.,
Hunt A.R.,
Johnson C.M.,
Joy A.A.,
Kay M.,
Keenan S.J.,
Kimberley A.M.,
King A.,
Laird G.K.,
Langford C.,
Lawlor S.,
Leongamornlert D.A.,
Leversha M.,
Lloyd C.R.,
Lloyd D.M.,
Loveland J.E.,
Lovell J.,
Martin S.,
Mashreghi-Mohammadi M.,
Maslen G.L.,
Matthews L.,
McCann O.T.,
McLaren S.J.,
McLay K.,
McMurray A.,
Moore M.J.F.,
Mullikin J.C.,
Niblett D.,
Nickerson T.,
Novik K.L.,
Oliver K.,
Overton-Larty E.K.,
Parker A.,
Patel R.,
Pearce A.V.,
Peck A.I.,
Phillimore B.J.C.T.,
Phillips S.,
Plumb R.W.,
Porter K.M.,
Ramsey Y.,
Ranby S.A.,
Rice C.M.,
Ross M.T.,
Searle S.M.,
Sehra H.K.,
Sheridan E.,
Skuce C.D.,
Smith S.,
Smith M.,
Spraggon L.,
Squares S.L.,
Steward C.A.,
Sycamore N.,
Tamlyn-Hall G.,
Tester J.,
Theaker A.J.,
Thomas D.W.,
Thorpe A.,
Tracey A.,
Tromans A.,
Tubby B.,
Wall M.,
Wallis J.M.,
West A.P.,
White S.S.,
Whitehead S.L.,
Whittaker H.,
Wild A.,
Willey D.J.,
Wilmer T.E.,
Wood J.M.,
Wray P.W.,
Wyatt J.C.,
Young L.,
Younger R.M.,
Bentley D.R.,
Coulson A.,
Durbin R.M.,
Hubbard T.,
Sulston J.E.,
Dunham I.,
Rogers J.,
Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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TISSUE SPECIFICITY.
DOI=10.1042/0264-6021:3440189; PubMed=10548550 [NCBI, ExPASy, EBI, Israel, Japan]
Kobayashi T.,
Deak M.,
Morrice N.,
Cohen P.;
"Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.";
Biochem. J. 344:189-197(1999).
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[7]
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PHOSPHORYLATION AT THR-256 AND SER-422, AND MUTAGENESIS OF THR-256 AND SER-422.
TISSUE=Brain;
DOI=10.1042/0264-6021:3390319; PubMed=10191262 [NCBI, ExPASy, EBI, Israel, Japan]
Kobayashi T.,
Cohen P.;
"Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2.";
Biochem. J. 339:319-328(1999).
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[8]
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CHARACTERIZATION.
DOI=10.1073/pnas.97.14.8157; PubMed=10884438 [NCBI, ExPASy, EBI, Israel, Japan]
Lang F.,
Klingel K.,
Wagner C.A.,
Stegen C.,
Waerntges S.,
Friedrich B.,
Lanzendoerfer M.,
Melzig J.,
Moschen I.,
Steuer S.,
Waldegger S.,
Sauter M.,
Paulmichl M.,
Gerke V.,
Risler T.,
Gamba G.,
Capasso G.,
Kandolf R.,
Hebert S.C., ![]()
Massry S.G.,
Broer S.;
"Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy.";
Proc. Natl. Acad. Sci. U.S.A. 97:8157-8162(2000).
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[9]
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FUNCTION.
DOI=10.1128/MCB.21.3.952-965.2001; PubMed=11154281 [NCBI, ExPASy, EBI, Israel, Japan]
Brunet A.,
Park J.,
Tran H.,
Hu L.S.,
Hemmings B.A.,
Greenberg M.E.;
"Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a).";
Mol. Cell. Biol. 21:952-965(2001).
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[10]
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INTERACTION WITH NEDD4 AND NEDD4L, MUTAGENESIS OF LYS-127; TYR-298 AND SER-422, AND FUNCTION.
DOI=10.1074/jbc.C100623200; PubMed=11696533 [NCBI, ExPASy, EBI, Israel, Japan]
Snyder P.M.,
Olson D.R.,
Thomas B.C.;
"Serum and glucocorticoid-regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel.";
J. Biol. Chem. 277:5-8(2002).
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[11]
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FUNCTION.
DOI=10.1007/s00424-002-0873-2; PubMed=12397388 [NCBI, ExPASy, EBI, Israel, Japan]
Gamper N.,
Fillon S.,
Feng Y.,
Friedrich B.,
Lang P.A.,
Henke G.,
Huber S.M.,
Kobayashi T.,
Cohen P.,
Lang F.;
"K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.";
Pflugers Arch. 445:60-66(2002).
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[12]
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FUNCTION, AND MUTAGENESIS OF LYS-127 AND SER-422.
PubMed=12911626 [NCBI, ExPASy, EBI, Israel, Japan]
Boehmer C.,
Henke G.,
Schniepp R.,
Palmada M.,
Rothstein J.D.,
Broeer S.,
Lang F.;
"Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B.";
J. Neurochem. 86:1181-1188(2003).
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[13]
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NUCLEAR LOCALIZATION SIGNAL.
DOI=10.1091/mbc.E02-03-0170; PubMed=12631736 [NCBI, ExPASy, EBI, Israel, Japan]
Maiyar A.C.,
Leong M.L.,
Firestone G.L.;
"Importin-alpha mediates the regulated nuclear targeting of serum- and glucocorticoid-inducible protein kinase (Sgk) by recognition of a nuclear localization signal in the kinase central domain.";
Mol. Biol. Cell 14:1221-1239(2003).
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[14]
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FUNCTION, AND MUTAGENESIS OF LYS-127 AND SER-422.
DOI=10.1002/jcp.10430; PubMed=15040001 [NCBI, ExPASy, EBI, Israel, Japan]
Henke G.,
Maier G.,
Wallisch S.,
Boehmer C.,
Lang F.;
"Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1.";
J. Cell. Physiol. 199:194-199(2004).
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[15]
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UBIQUITINATION.
DOI=10.1074/jbc.M411053200; PubMed=15576372 [NCBI, ExPASy, EBI, Israel, Japan]
Zhou R.,
Snyder P.M.;
"Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.";
J. Biol. Chem. 280:4518-4523(2005).
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[16]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74; SER-78; SER-397 AND SER-401, AND MASS SPECTROMETRY.
DOI=10.1016/j.molcel.2008.07.007; PubMed=18691976 [NCBI, ExPASy, EBI, Israel, Japan]
Daub H.,
Olsen J.V.,
Bairlein M.,
Gnad F.,
Oppermann F.S.,
Korner R.,
Greff Z.,
Keri G.,
Stemmann O.,
Mann M.;
"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.";
Mol. Cell 31:438-448(2008).
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[17]
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VARIANTS [LARGE SCALE ANALYSIS] ILE-219 AND VAL-342.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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