[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-27.
DOI=10.1006/geno.1997.4821; PubMed=9268630 [NCBI, ExPASy, EBI, Israel, Japan]
Peng Y.,
Schwarz E.J.,
Lazar M.A.,
Genin A.,
Spinner N.B.,
Taub R.;
"Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.";
Genomics 43:278-284(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 40-61 AND 64-83, MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INTERACTION WITH SCAP AND SREBP2 COMPLEX.
DOI=10.1016/S0092-8674(02)00872-3; PubMed=12202038 [NCBI, ExPASy, EBI, Israel, Japan]
Yang T.,
Espenshade P.J.,
Wright M.E.,
Yabe D.,
Gong Y.,
Aebersold R.,
Goldstein J.L.,
Brown M.S.;
"Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.";
Cell 110:489-500(2002).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N.,
Chen X.,
Rolfs A.,
Halleck A.,
Hines L.,
Eisenstein S.,
Koundinya M.,
Raphael J.,
Moreira D.,
Kelley T.,
LaBaer J.,
Lin Y.,
Phelan M.,
Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1083423; PubMed=12690205 [NCBI, ExPASy, EBI, Israel, Japan]
Scherer S.W.,
Cheung J.,
MacDonald J.R.,
Osborne L.R.,
Nakabayashi K.,
Herbrick J.-A.,
Carson A.R.,
Parker-Katiraee L.,
Skaug J.,
Khaja R.,
Zhang J.,
Hudek A.K.,
Li M.,
Haddad M.,
Duggan G.E.,
Fernandez B.A.,
Kanematsu E.,
Gentles S.,
Christopoulos C.C., ![]()
Choufani S.,
Kwasnicka D.,
Zheng X.H.,
Lai Z.,
Nusskern D.R.,
Zhang Q.,
Gu Z.,
Lu F.,
Zeesman S.,
Nowaczyk M.J.,
Teshima I.,
Chitayat D.,
Shuman C.,
Weksberg R.,
Zackai E.H.,
Grebe T.A.,
Cox S.R.,
Kirkpatrick S.J.,
Rahman N.,
Friedman J.M.,
Heng H.H.Q.,
Pelicci P.G.,
Lo-Coco F.,
Belloni E.,
Shaffer L.G.,
Pober B.,
Morton C.C.,
Gusella J.F.,
Bruns G.A.P.,
Korf B.R.,
Quade B.J.,
Ligon A.H.,
Ferguson H.,
Higgins A.W.,
Leach N.T.,
Herrick S.R.,
Lemyre E.,
Farra C.G.,
Kim H.-G.,
Summers A.M.,
Gripp K.W.,
Roberts W.,
Szatmari P.,
Winsor E.J.T.,
Grzeschik K.-H.,
Teebi A.,
Minassian B.A.,
Kere J.,
Armengol L.,
Pujana M.A.,
Estivill X.,
Wilson M.D.,
Koop B.F.,
Tosi S.,
Moore G.E.,
Boright A.P.,
Zlotorynski E.,
Kerem B.,
Kroisel P.M.,
Petek E.,
Oscier D.G.,
Mould S.J.,
Doehner H.,
Doehner K.,
Rommens J.M.,
Vincent J.B.,
Venter J.C.,
Li P.W.,
Mural R.J.,
Adams M.D.,
Tsui L.-C.;
"Human chromosome 7: DNA sequence and biology.";
Science 300:767-772(2003).
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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FUNCTION.
DOI=10.1016/S1097-2765(02)00822-5; PubMed=12535518 [NCBI, ExPASy, EBI, Israel, Japan]
Sever N.,
Yang T.,
Brown M.S.,
Goldstein J.L.,
DeBose-Boyd R.A.;
"Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.";
Mol. Cell 11:25-33(2003).
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[7]
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TOPOLOGY.
DOI=10.1074/jbc.M312623200; PubMed=14660594 [NCBI, ExPASy, EBI, Israel, Japan]
Feramisco J.D.,
Goldstein J.L.,
Brown M.S.;
"Membrane topology of human insig-1, a protein regulator of lipid synthesis.";
J. Biol. Chem. 279:8487-8496(2004).
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[8]
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FUNCTION, INTERACTION WITH SCAP AND SREBP2 COMPLEX, UBIQUITINATION AT LYS-156 AND LYS-158, AND MUTAGENESIS OF LYS-156 AND LYS-158.
DOI=10.1016/j.cmet.2005.11.014; PubMed=16399501 [NCBI, ExPASy, EBI, Israel, Japan]
Gong Y.,
Lee J.N.,
Lee P.C.,
Goldstein J.L.,
Brown M.S.,
Ye J.;
"Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake.";
Cell Metab. 3:15-24(2006).
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[9]
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FUNCTION, AND MUTAGENESIS OF ASP-205.
DOI=10.1073/pnas.0601923103; PubMed=16606821 [NCBI, ExPASy, EBI, Israel, Japan]
Gong Y.,
Lee J.N.,
Brown M.S.,
Goldstein J.L.,
Ye J.;
"Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.";
Proc. Natl. Acad. Sci. U.S.A. 103:6154-6159(2006).
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