FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity).
CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO₃^- = ADP + phosphate + malonyl-CoA.
PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1 .
SUBUNIT: Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (accB), biotin carboxylase (accC) and two subunits each of ACCase subunit alpha (accA) and ACCase subunit beta (accD) (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the accA family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000927; ABZ69865.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001682363.1; -.

3D structure databases

ModBase

B0T8G4.

Ontologies

GO:0003989;	Molecular function: acetyl-CoA carboxylase activity (inferred from electronic annotation from HAMAP).
GO:0006633;	Biological process: fatty acid biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00823; -; 1.
PBIL [Tree]

InterPro

IPR001095; Acetyl_CoA_COase_a_su.
IPR011763; COA_CT_C.
Graphical view of domain structure.

PANTHER

PTHR22855:SF3; Ac-CoA_carboxylA; 1.

Pfam

PF03255; ACCA; 1.
Pfam graphical view of domain structure.

PROSITE

PS50989; COA_CT_CTER; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

5898188; -.

GenomeReviews

CP000927_GR; Caul_0734.

KEGG

cak:Caul_0734; -.

CMR

B0T8G4; Caul_0734.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; Fatty acid biosynthesis; Ligase; Lipid synthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 320`	`320`		`Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha.`	`PRO_1000083922`

Sequence information

Length: 320 AA [This is the length of the unprocessed precursor]

Molecular weight: 34625 Da [This is the MW of the unprocessed precursor]

CRC64: 6DE4EC3D91D983D8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAHYLDFER PIADLESKIE ELSKLSETAG PGAFESEIQA LRDRAQQMRK EAYAGLDAWQ 

        70         80         90        100        110        120 
KTMVARHPER PHLKDYIAGL IDEFVELRGD RKFADDQAIV GGLGRFRGVP VVVMGHEKGH 

       130        140        150        160        170        180 
DTTTRLKHNF GMARPEGYRK AVRLMDMAER FNLPVITFVD TAGAYPGLGA EERGQAEAIA 

       190        200        210        220        230        240 
RSTERGLVLG TPMVATIVGE GGSGGAIALA GANKVLILEH SIYSVISPEG AASILWRDGA 

       250        260        270        280        290        300 
RAKDAAANMK ITAQDLIQLK IVDRIVEEPA GGAHSDPDAA IQSVGDAVED ELKALMKLSA 

       310        320 
AELKKQRAAR FYAIGREGLQ

B0T8G4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools