[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Testis; NIH - Xenopus Gene Collection (XGC) project; Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b composed of sdhc and sdhd (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC158270; AAI58271.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001120000.1; -.

3D structure databases

ModBase

B0BM36.

Ontologies

GO:0005743;	Cellular component: mitochondrial inner membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0051537;	Molecular function: 2 iron, 2 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051538;	Molecular function: 3 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051539;	Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005506;	Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008177;	Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from electronic annotation from EC).
GO:0022900;	Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810;	Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

100144957; -.

KEGG

xtr:100144957; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 26`	`26`	`Mitochondrion (By similarity).`
`CHAIN`	`27 284`	`258`	`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial.`	`PRO_0000343803`
`DOMAIN`	`44 137`	`94`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`180 210`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`97 97`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`102 102`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`105 105`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`117 117`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`190 190`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`193 193`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`196 196`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`200 200`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`247 247`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`253 253`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`257 257`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`205 205`		`Ubiquinone; shared with dhsd (By similarity).`

Sequence information

Length: 284 AA [This is the length of the unprocessed precursor]

Molecular weight: 32087 Da [This is the MW of the unprocessed precursor]

CRC64: 88CCE71B1DCB3D6C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAVVFSLRR SGPVFRLPGV LQVCRGAQTA AAAAPASQAE ARIKKFAIYR WDPDKPGDKP 

        70         80         90        100        110        120 
RMQTYEVDLN ECGSMVLDAL IKIKNEMDPT LTFRRSCREG ICGSCAMNIN GGNTLACTVR 

       130        140        150        160        170        180 
IDTNLSKVSK IYPLPHMYVV KDLVPDLSNF YAQYKSIEPY LKKKDESQEG KEQYLQSIED 

       190        200        210        220        230        240 
RDKLDGLYEC ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWMIDSRDDY TEERLAKLQD 

       250        260        270        280 
PFSLYRCHTI MNCTRTCPKG LNPGKAIAEI KKMMATYKER AASV

B0BM36 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools