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- FUNCTION: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).
- SUBCELLULAR LOCATION: Secreted (By similarity).
- DOMAIN: The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin (By similarity).
- SIMILARITY: Contains 1 agouti domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 132 AA [This is the length of the unprocessed precursor] |
Molecular weight: 14673 Da [This is the MW of the unprocessed precursor] |
CRC64: 373A273D6B667C80 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MDVTRLLLAT LLVFLCFFTV YSHLPPEEKL RDDRSLRSNS SVNLLDFPSV SIVALNKKSK
70 80 90 100 110 120
QISRKEAEKK RSSKKEASMK KVAQPRTPLS APCVATRDSC KPPAPACCDP CASCQCRFFR
130
SACSCRVLSL NC
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A1YL72 in FASTA format |
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ExPASy Home page
SIB Switzerland
