ID   AROE_COXBR              Reviewed;         272 AA.
AC   A9NBH0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-NOV-2008, entry version 11.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=COXBURSA331_A2191;
OS   Coxiella burnetii (strain RSA 331 / Henzerling II).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Coxiellaceae; Coxiella.
OX   NCBI_TaxID=360115;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Seshadri R., Samuel J.E.;
RT   "Genome sequencing of phylogenetically and phenotypically diverse
RT   Coxiella burnetii isolates.";
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; CP000890; ABX77620.1; -; Genomic_DNA.
DR   RefSeq; YP_001597801.1; -.
DR   GeneID; 5793247; -.
DR   GenomeReviews; CP000890_GR; aroE.
DR   KEGG; cbs:COXBURSA331_A2191; -.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   InterPro; IPR011342; Quinate/shikimate_5-DHase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    272       Shikimate dehydrogenase.
FT                                /FTId=PRO_1000078118.
FT   NP_BIND     127    131       NADP (By similarity).
FT   ACT_SITE     65     65       Proton acceptor (Potential).
SQ   SEQUENCE   272 AA;  29794 MW;  F1DA0DAB51DADB73 CRC64;
     MDKYAVIGNP VEHSLSPVIF QAFEKQTNHS FDYLKIKAPV NGFAAAVKKF HDEGGKGANI
     TLPFKEEAYQ LADKRSQEAN EAHVASALQF REDGTIYAVN YDGLGLVQDL TRNHNITLTQ
     KSILIVGAGG ATRGILGPLL NAAPEKIVIV NRTPSKAHAL AKIFHLRGEI QGGGFDELEP
     MRYDVIIHAT SLGHQGKFPP LPDGLIGSQS CCYDLSYGKI ASPFLQWAKD QGAKYNFDGL
     GMLVEHNAAV FYLWFGIYPD TNPVIEMLQA HL
//