[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Fulton R., Cordes M., Wollam A., Shah N., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.; Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity).
CATALYTIC ACTIVITY: Cytidine + H₂O = uridine + NH₃.
COFACTOR: Binds 1 zinc ion (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000886; ABX66257.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001587090.1; -.

3D structure databases

ModBase

A9N6L3.

Ontologies

GO:0004126;	Molecular function: cytidine deaminase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01558; -; 1.
PBIL [Tree]

InterPro

IPR006263; Cyt_deam_dimer.
Graphical view of domain structure.

TIGRFAMs

TIGR01355; cyt_deam_dimer; 1.

PROSITE

PS00903; CYT_DCMP_DEAMINASES; 1.

Genome annotation databases

GeneID

5781887; -.

GenomeReviews

CP000886_GR; SPAB_00833.

KEGG

spq:SPAB_00833; -.

CMR

A9N6L3; SPAB_00833.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Hydrolase; Metal-binding; Zinc.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 294`	`294`	`Cytidine deaminase.`	`PRO_1000087796`
`REGION`	`89 91`	`3`	`Substrate binding (By similarity).`
`ACT_SITE`	`104 104`		`Proton donor (By similarity).`
`METAL`	`102 102`		`Zinc; catalytic (By similarity).`
`METAL`	`129 129`		`Zinc; catalytic (By similarity).`
`METAL`	`132 132`		`Zinc; catalytic (By similarity).`

Sequence information

Length: 294 AA [This is the length of the unprocessed precursor]

Molecular weight: 31619 Da [This is the MW of the unprocessed precursor]

CRC64: B9685CBDC800A8C8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MHPRFQTAFA QLADNLQSAL APILADHHFP AMLTAEQVST LKNTAGLDED ALAFALLPLA 

        70         80         90        100        110        120 
AACARTDLSH FNVGAIARGV SGNWYFGANM EFLGATMQQT VHAEQSAISH AWLRGEKGLA 

       130        140        150        160        170        180 
AVTVNYTPCG HCRQFMNELN SGLDLRIHLP GRAPHTLRDY LPDAFGPKDL EIKTLLMDEQ 

       190        200        210        220        230        240 
DHGFTLTGDT LTQAAITAAN KSHMPYSHSP SGVALECKDG RIFTGSYAEN AAFNPTLPPL 

       250        260        270        280        290 
QGALNLLSLN GYDYADIQRA ILAEKGDAAL IQWDATAATL KALGCHNIDR VLLG

A9N6L3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools