NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/ng.2007.38; PubMed=18037886 [NCBI, ExPASy, EBI, Israel, Japan]
Saenz H.L., Engel P., Stoeckli M.C., Lanz C., Raddatz G., Vayssier-Taussat M., Birtles R., Schuster S.C., Dehio C.;
"Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors.";
Nat. Genet. 39:1469-1476(2007).

Comments

CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5 .
SIMILARITY: Belongs to the SAICAR synthetase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AM260525; CAK01712.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001609707.1; -.

3D structure databases

ModBase

A9IVH1.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004639;	Molecular function: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity (inferred from electronic annotation from HAMAP).
GO:0006164;	Biological process: purine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00137; -; 1.
PBIL [Tree]

InterPro

IPR013816; ATP_grasp_subdomain_2.
IPR001636; SAICAR_synt.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.

PANTHER

PTHR11609; SAICAR_synt; 1.

ProDom

PD003043; SAICAR_synt; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00081; purC; 1.

PROSITE

PS01057; SAICAR_SYNTHETASE_1; 1.
PS01058; SAICAR_SYNTHETASE_2; FALSE_NEG.

Genome annotation databases

GeneID

5829879; -.

GenomeReviews

AM260525_GR; BT1350.

CMR

A9IVH1; BT1350.

Other

ProtoNet

A9IVH1.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Ligase; Purine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 254`	`254`		`Phosphoribosylaminoimidazole-succinocarboxamide synthase.`	`PRO_1000076445`

Sequence information

Length: 254 AA [This is the length of the unprocessed precursor]

Molecular weight: 29181 Da [This is the MW of the unprocessed precursor]

CRC64: 761AB56EA8403745 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNRRHRIYEG KAKILYEGPE PGTYIQFFKD DATAFNAKKH EIIDGKGVLN NRISEHIFSH 

        70         80         90        100        110        120 
LGRLGIPTHF IKRINMREQL IKAVEIIPLE VVVRNVAAGS LAKRLGLEEG APLPQSIIEF 

       130        140        150        160        170        180 
YYKNDSLDDP MVTEEHITAF GWAVPQEIED IMQLSIRIND FLSGLFAGVN IQLIDFKMEF 

       190        200        210        220        230        240 
GRLWEDETMR IVLADEISPD SARLWDMQTR EKMDKDRFRR DMGGLINAYQ EVAKRLGIMN 

       250 
ENEPIRPSGP VLVK

A9IVH1 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools