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UniProtKB/Swiss-Prot entry A8YVZ5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_LACH4
Primary accession number A8YVZ5
Secondary accession numbers None
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on January 15, 2008 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 7)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: lhv_1445
From
Lactobacillus helveticus (strain DPC 4571) [TaxID: 405566] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01295-07; PubMed=17993529 [NCBI, ExPASy, EBI, Israel, Japan]
Callanan M., Kaleta P., O'Callaghan J., O'Sullivan O., Jordan K., McAuliffe O., Sangrador-Vegas A., Slattery L., Fitzgerald G.F., Beresford T., Ross R.P.;
"Genome sequence of Lactobacillus helveticus: an organism distinguished by selective gene loss and IS element expansion.";
J. Bacteriol. 190:727-735(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000517; ABX27424.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001577723.1; -.
3D structure databases
ModBase A8YVZ5.
Protein family/group databases
MEROPS M38.972; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS A8YVZ5.
Genome annotation databases
GeneID 5771450; -.
GenomeReviews CP000517_GR; lhv_1445.
KEGG lhe:lhv_1445; -.
CMR A8YVZ5; lhv_1445.
Other
ProtoNet A8YVZ5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_1000071755
METAL   56    56        Zinc 1 (By similarity). 
METAL   58    58        Zinc 1 (By similarity). 
METAL   138   138        Zinc 1; via carbamate group (By similarity). 
METAL   138   138        Zinc 2; via carbamate group (By similarity). 
METAL   175   175        Zinc 2 (By similarity). 
METAL   228   228        Zinc 2 (By similarity). 
METAL   301   301        Zinc 1 (By similarity). 
MOD_RES   138   138        N6-carboxylysine (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 46292 Da [This is the MW of the unprocessed precursor] CRC64: 187D96B072910B33 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQTVIKNGTV YQNGRLIHAD VLIEDQKIKA IGTDLTGDKV IDATGKLVSP GLVDVHVHYR 

        70         80         90        100        110        120 
DPGQTYKEDI ETGSKAAAHG GFTTVGAMPN VTPVPDTPDL MKKMVQENKQ KGIVHIFQYG 

       130        140        150        160        170        180 
PITKNETTDE LPDYAALKKA GAFALSNDGH GVQTAQTMYL AMQEAKKNDL IVAAHAQDDS 

       190        200        210        220        230        240 
LFNHGIVNEG EKAKELNLPP VTELAETTQI ARDLLLAEKT GVHYHICHVS TKTSVELVRM 

       250        260        270        280        290        300 
AKACGINVTC EAAPHHLLLT EDDIPKDNGY YKMNPPLRSK EDQAALLVGL LDGTIDLIAT 

       310        320        330        340        350        360 
DHAPHAKQEK QGGMQNAAFG ITGSETAFST LYTKFVKEDK VFTLEQLLSW LSDQPAKVFG 

       370        380        390        400        410        420 
LKKAGVLEPG CPADVAIFDL EHETELKEKD YQSKGINTPF TGQKIYGATV MTMVDGEVVY 


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A8YVZ5 in FASTA format

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