FUNCTION: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions (By similarity).
CATALYTIC ACTIVITY: NTP + H₂O = NDP + phosphate.
COFACTOR: Divalent cations (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the HAM1 NTPase family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000814; ABV52891.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001482868.1; -.

3D structure databases

ModBase

A8FN54.

Ontologies

GO:0017111;	Molecular function: nucleoside-triphosphatase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01405; -; 1.
PBIL [Tree]

InterPro

IPR002637; Ham1p_like.
Graphical view of domain structure.

PANTHER

PTHR11067; Ham1p_like; 1.

Pfam

PF01725; Ham1p_like; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00042; Ham1p_like; 1.

BLOCKS

A8FN54.

Genome annotation databases

GeneID

5618390; -.

GenomeReviews

CP000814_GR; C8J_1293.

KEGG

cju:C8J_1293; -.

CMR

A8FN54; C8J_1293.

Other

ProtoNet

A8FN54.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Hydrolase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 200`	`200`		`Nucleoside-triphosphatase.`	`PRO_1000073507`

Sequence information

Length: 200 AA [This is the length of the unprocessed precursor]

Molecular weight: 22421 Da [This is the MW of the unprocessed precursor]

CRC64: EEF3029AF5BB51DC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKIILATSNK HKVLELKEIL KDFEIYAFDE VLMPFEIEEN GKTFKENALI KARAVFNALD 

        70         80         90        100        110        120 
EKQKKDFIAL SDDSGICVDV LEGNPGIYSA RFSDKGDDKS NRDKLVNEMI KKGFNQSRAH 

       130        140        150        160        170        180 
YVAAIAMVGL MGEFSTHGTM HGKVIDTEKG ENGFGYDSLF IPKGFDKTLA QLSVDEKNNI 

       190        200 
SHRFKALELA KIILKILNKG

A8FN54 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools