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UniProtKB/Swiss-Prot entry A8FD15

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_BACP2
Primary accession number A8FD15
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on November 13, 2007 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 9)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: BPUM_1449
From
Bacillus pumilus (strain SAFR-032) [TaxID: 315750] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pone.0000928; PubMed=17895969 [NCBI, ExPASy, EBI, Israel, Japan]
Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D., Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H., Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y., Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P., Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D., Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F., Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K., Weinstock G.M.;
"Paradoxical DNA repair and peroxide resistance gene conservation in Bacillus pumilus SAFR-032.";
PLoS ONE 2:E928-E928(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000813; ABV62132.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001486692.1; -.
3D structure databases
ModBase A8FD15.
Protein family/group databases
MEROPS M38.972; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS A8FD15.
Genome annotation databases
GeneID 5620716; -.
GenomeReviews CP000813_GR; BPUM_1449.
KEGG bpu:BPUM_1449; -.
CMR A8FD15; BPUM_1449.
Other
ProtoNet A8FD15.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Dihydroorotase. PRO_1000058653
METAL   59    59        Zinc 1 (By similarity). 
METAL   61    61        Zinc 1 (By similarity). 
METAL   141   141        Zinc 1; via carbamate group (By similarity). 
METAL   141   141        Zinc 2; via carbamate group (By similarity). 
METAL   178   178        Zinc 2 (By similarity). 
METAL   231   231        Zinc 2 (By similarity). 
METAL   304   304        Zinc 1 (By similarity). 
MOD_RES   141   141        N6-carboxylysine (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46993 Da [This is the MW of the unprocessed precursor] CRC64: B50A9168280389E2 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSYLIKNGFI LTSTGEKVQQ DIRVEGEVIQ AIGHLEREDG EEVIDAKGLF VSPGLIDLHV 

        70         80         90        100        110        120 
HLREPGGEKK ETIETGSKAA ARGGYTTIAA MPNTRPVPDT KEQMEWLMNR IEETSSVRVL 

       130        140        150        160        170        180 
PYASITTRQI GEEMTDFAAL KEAGAFAFTD DGVGIQTAGM MYEAMKKAAS LDQAIVAHCE 

       190        200        210        220        230        240 
DNSLIYGGCV HEGEFSKANG LNGIPSICES VHIARDVLLA EAANCHYHVC HISTKESVRV 

       250        260        270        280        290        300 
VRDAKKAGIR VTAEVSPHHL LLCDADIPGL DTNYKMNPPL RGKEDREALI EGLLDGTIDF 

       310        320        330        340        350        360 
IATDHAPHTE EEKNETMQRA PFGIVGLETA FPLLYTRFVK TGEWTLKELV DYMTIKPAEA 

       370        380        390        400        410        420 
FSLPYGKLEK GQIADITLID LNKEMAIDKK SFLSKGQNTP FDKLTVSGWP VMTLASGKVV 


YEEGRLVK
A8FD15 in FASTA format

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