NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Podar M., Anderson I., Ivanova N., Wall M., Mavrommatis K., Lykidis A., Chen J., Hudson M., Deciu C., Hutchison D., Eads J., Fernandes F., Tamang D., Szeto E., Land M., Lapidus A., Kyrpides N., Chang C., Saier M., Eisen J., Rachel R., Huber H., Keller M., Richardson P., Stetter K.;
"Unicellular symbiosis at high temperature: genomic insights into the Ignicoccus hospitalis - Naoarchaeum equitans relationship.";
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA (By similarity).
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000816; ABU82122.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001435529.1; -.

3D structure databases

ModBase

A8AB20.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003910;	Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0006310;	Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281;	Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260;	Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00407; -; 1.
PBIL [Tree]

InterPro

IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.50.140; OB_NA_bd_sub; 1.

Pfam

PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00574; dnl1; 1.

PROSITE

PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

A8AB20.

Genome annotation databases

GeneID

5562329; -.

GenomeReviews

CP000816_GR; Igni_0942.

KEGG

iho:Igni_0942; -.

CMR

A8AB20; Igni_0942.

Other

ProtoNet

A8AB20.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 594`	`594`	`DNA ligase.`	`PRO_1000049867`
`ACT_SITE`	`258 258`		`N6-AMP-lysine intermediate (By similarity).`

Sequence information

Length: 594 AA [This is the length of the unprocessed precursor]

Molecular weight: 66459 Da [This is the MW of the unprocessed precursor]

CRC64: 2AB8030EEC27B803 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKFSDVVDAL ERLERTTSRT QIVAILTNLF KKVIEENKDI IDKVVYFIQG KLWPDWYGYP 

        70         80         90        100        110        120 
EIGIGEKGII KAISLAANVK EKEVEGLYKQ LGDLGLVAER LMAKAPKGGL MMFVKKKEEL 

       130        140        150        160        170        180 
TFEKVYETLK RIAFMQGEGS RDLKIKTLAG LLKEASPKEA KYIVRFVQGK LRLGVGDASI 

       190        200        210        220        230        240 
IEALAHVAGT TKDVVERAYN LRADLGAVAK IAVTEGPEAL KRVRPKPGVP VRPMLAERLN 

       250        260        270        280        290        300 
DPKEILKKLG GKGLAEYKYD GERAQIHLLP DGKVVIFSRR LENITRSYPD VVQYAKSGLK 

       310        320        330        340        350        360 
AKEAIVEGEI IAVNPETGEP RPFQELMRRR RKHDVALAMS EIPVNVKLFD IIYVDGEDMT 

       370        380        390        400        410        420 
NKPLPLRRKR LEEVVEESEE FSLSTAKLVS TPEELEQFFH QSISEGHEGL VVKAVHDKSV 

       430        440        450        460        470        480 
YQAGARGWLW IKYKKDYKSE MVEPVDLVVV GAFYGRGRRG GTFGALLVAG YDEKRDAFAT 

       490        500        510        520        530        540 
VCKVGSGFSD EELARLPELL KPYISETKPP RVISNVKPDV WVRPALVAEI IGAEITLSPI 

       550        560        570        580        590 
HTCAKDEVSA GSGLAIRFPR FIRWRPDKGP EDATTCGEIV EMYKSRLKKV EEPT

A8AB20 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools