NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0608218104; PubMed=17494770 [NCBI, ExPASy, EBI, Israel, Japan]
Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
"Independent sorting-out of thousands of duplicated gene pairs in two yeast species descended from a whole-genome duplication.";
Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).

Comments

FUNCTION: Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes (By similarity).
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DS480398; EDO17806.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

XP_001645664.1; -.

3D structure databases

ModBase

A7TIZ4.

Family and domain databases

InterPro

IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR002290; Ser_thr_pkinase.
Graphical view of domain structure.

Pfam

PF00069; Pkinase; 1.
Pfam graphical view of domain structure.

ProDom

PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00220; S_TKc; 1.
SMART graphical view of domain structure.

PROSITE

PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

A7TIZ4.

Genome annotation databases

GeneID

5546060; -.

KEGG

vpo:Kpol_541p49; -.

Other

ProtoNet

A7TIZ4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Autophagy; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Protein transport; Serine/threonine-protein kinase; Transferase; Transport.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 994`	`994`	`Serine/threonine-protein kinase atg1.`	`PRO_0000317799`
`DOMAIN`	`7 331`	`325`	`Protein kinase.`
`NP_BIND`	`13 21`	`9`	`ATP (By similarity).`
`COMPBIAS`	`377 525`	`149`	`Asn-rich.`
`ACT_SITE`	`178 178`		`Proton acceptor (By similarity).`
`BINDING`	`60 60`		`ATP (By similarity).`

Sequence information

Length: 994 AA [This is the length of the unprocessed precursor]

Molecular weight: 113085 Da [This is the MW of the unprocessed precursor]

CRC64: 9BD130D2C810CE81 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MIISGKYVIE KEIGKGSFAT VLKGYIIDDN DNNGNDTNNE DVEVNDDKRK YTTRNQIAVK 

        70         80         90        100        110        120 
AVPRSKLKNK KLLENLEVEI AILKKIKHPH IVRLIECERT STDFYLIMEY CALGDLTFLI 

       130        140        150        160        170        180 
KKRQEIMENH PLLKSVFKRF PPPSKNHNGL HRAFILNYLQ QLSSSLKFLR SKNLVHRDIK 

       190        200        210        220        230        240 
PQNLLLATPF VDYHDSKSFH DLGYVGISSL PILKIADFGF ARFLPNTSMA ETLCGSPLYM 

       250        260        270        280        290        300 
APEILNYQKY NAKADLWSVG TVLYEMCYGK PPFKASNHLE LYKKIKKANN TISYSNDCEI 

       310        320        330        340        350        360 
EDDLKDLINA LLTFDPNKRI GFQEFFDNKL VIEDLSKYEV ANEVYSELEL KSKSVLESNM 

       370        380        390        400        410        420 
FISEYLPSEK KKDDTDNMII SNLSTNDRIN NITIFSNILP TVNENENDKT NDNSTTNYNN 

       430        440        450        460        470        480 
NDNENNDNNN TNHNYNNDKV NNKSNDNNEK SDINRSNSNY KQHSTKQTTN ELIPNTNTIT 

       490        500        510        520        530        540 
TNINDNSNSE MNSQSARMMQ KSKNYKSLRN NKLRNSKNDI INNSNSDLIL EKEYVVVEKK 

       550        560        570        580        590        600 
SVEVNTLADE MAQIGQINNL NYKVPYPSRS PTLAGNVLQN NESLQHYQPF SVKSPRTSLS 

       610        620        630        640        650        660 
SNGSGNSRRA SLVDRRLSIS SLNPSNALSR ALGVASTKLF GSNVLPNQNA GVGNANNINT 

       670        680        690        700        710        720 
SMPLLNPQVF QDLTENILLR VDQLQGKDRI NIDSNSIVQI LESLAAKAFV VHSFAEVKFS 

       730        740        750        760        770        780 
QTIPLKSLST STVNRPANDR RLNDRGCAIE EDDNIQTETY DTYIPSLKGR SLSSLSQTSI 

       790        800        810        820        830        840 
CSQDLPHGEL YQLSKEAIIL YMKTLSILAT AMQITSNWWY QSNEKNCSLR LNLLVQWIRD 

       850        860        870        880        890        900 
KFNECLERAD FLRIQILELE ECENKSNELN SDHTDVETSG VNETVHNNDN DANEEDQIYV 

       910        920        930        940        950        960 
EKLLYDRALE ISRTAAKLEI QGDHLNNCEL AYATSLWMLE ILLDDRIEDD NFNEFSSKNS 

       970        980        990 
AVLDDQDREI IKKYIDSIAN RLKALREKIS QGGS

A7TIZ4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools