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UniProtKB/Swiss-Prot entry A7GRL3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_BACCN
Primary accession number A7GRL3
Secondary accession numbers None
Integrated into Swiss-Prot on March 18, 2008
Sequence was last modified on September 11, 2007 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 9)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: Bcer98_2537
From
Bacillus cereus subsp. cytotoxis (strain NVH 391-98) [TaxID: 315749] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/j.cbi.2007.03.003; PubMed=17434157 [NCBI, ExPASy, EBI, Israel, Japan]
Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C., Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V., Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J., Ehrlich S.D., Sorokin A.;
"Extending the Bacillus cereus group genomics to putative food-borne pathogens of different toxicity.";
Chem. Biol. Interact. 171:236-249(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000764; ABS22771.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001375766.1; -.
3D structure databases
ModBase A7GRL3.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS A7GRL3.
Genome annotation databases
GeneID 5344008; -.
GenomeReviews CP000764_GR; Bcer98_2537.
KEGG bcy:Bcer98_2537; -.
CMR A7GRL3; Bcer98_2537.
Other
ProtoNet A7GRL3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Dihydroorotase. PRO_0000325586
METAL   59    59        Zinc 1 (By similarity). 
METAL   61    61        Zinc 1 (By similarity). 
METAL   141   141        Zinc 1; via carbamate group (By similarity). 
METAL   141   141        Zinc 2; via carbamate group (By similarity). 
METAL   178   178        Zinc 2 (By similarity). 
METAL   231   231        Zinc 2 (By similarity). 
METAL   304   304        Zinc 1 (By similarity). 
MOD_RES   141   141        N6-carboxylysine (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46650 Da [This is the MW of the unprocessed precursor] CRC64: CC9BA7F44AC4A21A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNYLFKNGRY LNEEGTIVAT DLLVQDGKIA KIAKNISAEN AEVIDVNGKL IAPGLVDVHV 

        70         80         90        100        110        120 
HLREPGGEHK ETIETGTLAA AKGGFTTICA MPNTRPVPDS KEHMEDLQKR IQEKAHVNVL 

       130        140        150        160        170        180 
PYGAITVRQA GSEMTDFETL KELGAFAFTD DGVGVQDASM MLAAMKRAAK LNMAVVAHCE 

       190        200        210        220        230        240 
ENTLINKGCV HEGKFSEKHG LNGIPSVCES VHIARDILLA EAADCHYHVC HVSTKGSVRV 

       250        260        270        280        290        300 
IRDAKRAGIK VTAEVTPHHL VLCEDDIPSV DPNFKMNPPL RGREDQEALI EGLLDGTIDI 

       310        320        330        340        350        360 
IATDHAPHTA EEKAQGIERA PFGITGFETA FPLLYTNLVK KGIITLEQLI QFLTEKPADT 

       370        380        390        400        410        420 
FGLETGRLKE GRAADITILD LEQEEKIDPT TFLSKGKNTP FAGWKCQGWP VMTLVGGKIV 


WQKESALV
A7GRL3 in FASTA format

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