NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Reeve W.G., Richardson P.;
"Complete sequence of Sinorhizobium medicae WSM419 chromosome.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBCELLULAR LOCATION: Cytoplasm (Probable).
SIMILARITY: Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000738; ABR61848.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001328683.1; -.

3D structure databases

ModBase

A6UDW8.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0045020;	Biological process: error-prone DNA repair (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01902; -; 1.
PBIL [Tree]

InterPro

IPR011708; DNA_pol3_alpha.
IPR004365; NA_bd_OB_tRNA-helicase.
IPR004013; PHP_C.
IPR004805; PolC_alpha.
Graphical view of domain structure.

Pfam

PF07733; DNA_pol3_alpha; 1.
PF02811; PHP; 1.
PF01336; tRNA_anti; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00594; polc; 1.

BLOCKS

A6UDW8.

Genome annotation databases

GeneID

5323899; -.

GenomeReviews

CP000738_GR; Smed_3021.

KEGG

smd:Smed_3021; -.

CMR

A6UDW8; Smed_3021.

Other

ProtoNet

A6UDW8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Cytoplasm; DNA damage; DNA repair; DNA replication; DNA-directed DNA polymerase; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1116`	`1116`		`Error-prone DNA polymerase.`	`PRO_1000070598`

Sequence information

Length: 1116 AA [This is the length of the unprocessed precursor]

Molecular weight: 124942 Da [This is the MW of the unprocessed precursor]

CRC64: EFEAF91A4053FDD2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGDTAFYEL GACTNFSFLE GAAPAEEMVV FAKKARLAGL GIADRNSVAG VVRAHAKAKM 

        70         80         90        100        110        120 
ENYPFQPGAR LVFADGTPDV LAYPRNRRGW GHLCRLLSAG NLRSKKGDCT LHLADLLEWQ 

       130        140        150        160        170        180 
EELLLIVMPD RVRPEPESLK PLLGKLQEHA GNRLYLGLAP RYDGFDRHDF AVLATVARKA 

       190        200        210        220        230        240 
GIGLLATNDA LYHDPDYRPL ADVVTAIREH VPVAGAGFLL QKNAERHLKS PREMARLFSD 

       250        260        270        280        290        300 
YPEAIANTQK FFRHLAFSLD ELRHQYPDEN AGGETPAESL RRLVSEGAAE RYPEGVPEKV 

       310        320        330        340        350        360 
QRQIEYELEL INDKKYEPYF LTVHKLVKFA RSEKILCQGR GSAANSSVCF CLGITDVDPQ 

       370        380        390        400        410        420 
KFTLLFDRFL SKDRDEPPDI DVDFEHERRE EVIQYIYRTY GKEHAGLAAA VISYRSRSAG 

       430        440        450        460        470        480 
REVAKAFGFS EDVQSALVSS IWGWGNSPFT EEQARGAGLD AADPSTRRVL AYASLLMNYP 

       490        500        510        520        530        540 
RHLSQHVGGF VITRDRLDEV VPIMNTAMPD RYMIEWDKDD LDELKILKVD VLALGMLTCL 

       550        560        570        580        590        600 
AKGFKLLEAH YGEPITLAEI YQDHQPAVYD MICRADTVGV FQIESRAQMS MLPRLQPREM 

       610        620        630        640        650        660 
YDLVIEVAIV RPGPIQGNMV HPYLKRREGQ RKGEKVKYPS PELKAVLERT LGVPLFQEQA 

       670        680        690        700        710        720 
MQIAITAAGF SPSEADRLRR AMATFKRTGT IHTFERKMVE GMVANGYERE FAERCFNQIK 

       730        740        750        760        770        780 
GFGEYGFPES HAASFASLVY ASAWLKTYYP DIFCAALLNA QPMGFYAPAQ LVRDAREHGV 

       790        800        810        820        830        840 
KVLPVDINHS DWDALLEGEG QFRKESVDPR HADMREVIKT RKAVRLGFRL VKGLKQADMG 

       850        860        870        880        890        900 
ALVACRGEGY RSVHDLWFRS GLSRSVLERL ADADAFRSLG LDRRAALWAV KALDEQSAVE 

       910        920        930        940        950        960 
RLPLFEGAGS LDLRAEPKVA LPEMPAGEQV IHDYRTLTLS LKAHPVSFMR EDFSRTGILR 

       970        980        990       1000       1010       1020 
SRDLAATATG KWVTVAGLVL VRQRPGSANG VIFMTIEDET GIANIIVWEK TFRKYRPQVM 

      1030       1040       1050       1060       1070       1080 
GSRLVKIRGR LQNQSGVIHV VADHLEDITP MLGLLRREAR RFGANDRADG ALRPSGDARE 

      1090       1100       1110 
KRKLRQLRLG LPGGAEPEGE AAAQVAEAMP KGRNFH

A6UDW8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools