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UniProtKB/Swiss-Prot entry A6T9K7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_KLEP7
Primary accession number A6T9K7
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on August 21, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 11)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: KPN78578_18170
ORFNames: KPN_01847
From
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) [TaxID: 272620] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Klebsiella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P., Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000647; ABR77278.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001335508.1; -.
3D structure databases
ModBase A6T9K7.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A6T9K7.
Genome annotation databases
GeneID 5342907; -.
GenomeReviews CP000647_GR; KPN78578_18170.
KEGG kpn:KPN_01847; -.
CMR A6T9K7; KPN78578_18170.
Other
ProtoNet A6T9K7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   565  565     NAD-dependent malic enzyme. PRO_1000069532
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   418   418        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 565 AA [This is the length of the unprocessed precursor] Molecular weight: 62772 Da [This is the MW of the unprocessed precursor] CRC64: DF7B97719BF4F195 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MQFTHKKNRS LYIPYAGPVL LEFPLLNKGS AFSMEERSNF NLLGLLPEVV ETIEEQAERA 

        70         80         90        100        110        120 
WIQYQGFKTE IDKHIYLRNI QDTNETLFYR LIGNHLEEMM PVIYTPTVGA ACERFSEIYR 

       130        140        150        160        170        180 
RARGVFISYQ NRHNLDDILQ NVPNHNVKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
TCGGISPAYT LPIVLDVGTN NQQLLDDPLY MGWRHPRITD DEYYQFVDDV IQAIKARWPD 

       250        260        270        280        290        300 
VLLQFEDFAQ KNAMPLLNRY RNEICSFNDD IQGTAAVTVG TLIAASRGAG SQLSEQKIVF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIIAQIVR EGLSEEEARQ RVFMVDRFGL LTDGMPNLLP FQNKLVQKRE 

       370        380        390        400        410        420 
QLQSWDTTSE ALSLLDVVRN VKPNILIGVS GQPGLFTEEI IREMHKHCPR PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEATPQNI LSWTDGEALV ATGSPFSPVT VKGKQYPIAQ CNNSYIFPGI GLGVIASGAS 

       490        500        510        520        530        540 
RVTDEMLMAA SETLAQHSPL VNNGEGPVLP ELKDIQTVSR AIAFAVGKVA QEQGVAVKTS 

       550        560 
AEALLQAISD NFWLPEYRNY RRTSI
A6T9K7 in FASTA format

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