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UniProtKB/Swiss-Prot entry A5E8E8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information

Entry name

HIS4_BRASB

Primary accession number

A5E8E8

Secondary accession numbers

None

Integrated into Swiss-Prot on

February 5, 2008

Sequence was last modified on

June 12, 2007 (Sequence version 1)

Annotations were last modified on

July 22, 2008 (Entry version 10)

Name and origin of the protein

Protein name

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Synonyms

EC 5.3.1.16
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Gene name

	Name:	hisA
	OrderedLocusNames:	BBta_0145

From

Bradyrhizobium sp. (strain BTAi1 / ATCC BAA-1182)

[TaxID: 288000]

[HAMAP proteome]

Taxonomy

Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Bradyrhizobiaceae; Bradyrhizobium.

Protein existence

3: Inferred from homology;

References

[1]

NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1139548; PubMed=17540897 [NCBI, ExPASy, EBI, Israel, Japan]
Giraud E., Moulin L., Vallenet D., Barbe V., Cytryn E., Avarre J.-C., Jaubert M., Simon D., Cartieaux F., Prin Y., Bena G., Hannibal L., Fardoux J., Kojadinovic M., Vuillet L., Lajus A., Cruveiller S., Rouy Z., Mangenot S., Segurens B., Dossat C., Franck W.L., Chang W.-S., Saunders E., Bruce D., Richardson P., Normand P., Dreyfus B., Pignol D., Stacey G., Emerich D., Vermeglio A., Medigue C., Sadowsky M.;
"Legumes symbioses: absence of nod genes in photosynthetic bradyrhizobia.";
Science 316:1307-1312(2007).

Comments

CATALYTIC ACTIVITY: 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide.
PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the hisA/hisF family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000494; ABQ32442.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001236348.1; -.

3D structure databases

ModBase

A5E8E8.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003949;	Molecular function: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity (inferred from electronic annotation from HAMAP).
GO:0000105;	Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01014; -; 1.
PBIL [Tree]

InterPro

IPR006063; His4.
IPR006062; His_biosynth.
Graphical view of domain structure.

Pfam

PF00977; His_biosynth; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00007; His4; 1.

Genome annotation databases

GeneID

5149957; -.

GenomeReviews

CP000494_GR; BBta_0145.

KEGG

bbt:BBta_0145; -.

CMR

A5E8E8; BBta_0145.

Other

ProtoNet

A5E8E8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Complete proteome; Cytoplasm; Histidine biosynthesis; Isomerase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 247`	`247`	`1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.`	`PRO_1000063187`
`ACT_SITE`	`8 8`		`Proton acceptor (By similarity).`
`ACT_SITE`	`129 129`		`Proton donor (By similarity).`

Sequence information

Length: 247 AA [This is the length of the unprocessed precursor]

Molecular weight: 25858 Da [This is the MW of the unprocessed precursor]

CRC64: C55E48CC32172C72 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MILFPAIDLK NGQCVRLEQG DMARATVFNL DPAAQAKSFA DQGFDYLHVV DLDGAFAGKP 

        70         80         90        100        110        120 
MNAQAVEAML KVVKMPVQLG GGIRDLKTVE AWLNKGITRV IIGTAAVRDP ELVKTAAKAF 

       130        140        150        160        170        180 
PGRVAVGLDA RDGKVAVEGW AETSEVTALD IAKRFEDAGV AAIIFTDIAR DGLLKGLNLD 

       190        200        210        220        230        240 
ATIALGDAVS IPVIASGGLA SIEDVKAMLT PRARKLEGAI AGRALYDGRL DPAEALALIR 


AARKAGA

A5E8E8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools