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UniProtKB/Swiss-Prot entry A5CPZ4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LEU3_CLAM3
Primary accession number A5CPZ4
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on June 12, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 12)
Name and origin of the protein
Protein name 3-isopropylmalate dehydrogenase
Synonyms EC 1.1.1.85
Beta-IPM dehydrogenase
IMDH
3-IPM-DH
Gene name
Name: leuB
OrderedLocusNames: CMM_1104
From
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [TaxID: 443906] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Microbacteriaceae; Clavibacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01595-07; PubMed=18192381 [NCBI, ExPASy, EBI, Israel, Japan]
Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C., Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.;
"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity.";
J. Bacteriol. 190:2138-2149(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AM711867; CAN01147.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001221845.1; -.
3D structure databases
ModBase A5CPZ4.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0003862; Molecular function: 3-isopropylmalate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009098; Biological process: leucine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01035; -; 1.
PBIL [Tree]
InterPro IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11835; IDH_IMDH_dimeric; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS A5CPZ4.
Genome annotation databases
GeneID 5175261; -.
GenomeReviews AM711867_GR; CMM_1104.
KEGG cmi:CMM_1104; -.
CMR A5CPZ4; CMM_1104.
Other
ProtoNet A5CPZ4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Cytoplasm; Leucine biosynthesis; Magnesium; Manganese; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   355  355     3-isopropylmalate dehydrogenase. PRO_1000063869
NP_BIND   283   295  13     NAD (By similarity). 
METAL   223   223        Magnesium or manganese (By similarity). 
METAL   247   247        Magnesium or manganese (By similarity). 
METAL   251   251        Magnesium or manganese (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   108   108        Substrate (By similarity). 
BINDING   132   132        Substrate (By similarity). 
BINDING   223   223        Substrate (By similarity). 
SITE   139   139  1     Important for catalysis (By similarity). 
SITE   190   190  1     Important for catalysis (By similarity). 
Sequence information
Length: 355 AA [This is the length of the unprocessed precursor] Molecular weight: 37179 Da [This is the MW of the unprocessed precursor] CRC64: E2BD12E685D06224 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPRTISLAVV PGDGIGPEVV HEALRVLREA VPADVSLDTT QYPFGAGHFL ETGEILTDSD 

        70         80         90        100        110        120 
LAALAQHDAI LLGAVGGDPR DARLAGGIIE RGLLLKLRFA FDHYINLRPT TLLPGVTSPL 

       130        140        150        160        170        180 
ASPGEVDFVV VREGTEGPYA GNGGVLRRGT EHEIATEVSV NTAHGVERTV RFAFDLASKR 

       190        200        210        220        230        240 
ERKRVTLVHK TNVLTFAGSL WQRTVDRVAA EHPDVAVDYL HVDATMIFLV TDPSRFDVIV 

       250        260        270        280        290        300 
SDNLFGDIIT DLAAAISGGI GLAASGNVNP TGAFPSMFEP VHGSAPDIAG QQKADPTAAI 

       310        320        330        340        350 
LSVSLLLDHL GLPEAAARVT AAVSADLAAR AAGDPAPRST AEVGDAVIRA LSTNH
A5CPZ4 in FASTA format

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