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UniProtKB/Swiss-Prot entry A4WAJ3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_ENT38
Primary accession number A4WAJ3
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on May 29, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 12)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: Ent638_2047
From
Enterobacter sp. (strain 638) [TaxID: 399742] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Enterobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.;
"Complete sequence of chromosome of Enterobacter sp. 638.";
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000653; ABP60723.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001176774.1; -.
3D structure databases
ModBase A4WAJ3.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A4WAJ3.
Genome annotation databases
GeneID 5113463; -.
GenomeReviews CP000653_GR; Ent638_2047.
NMPDR fig|399742.4.peg.2000; -.
CMR A4WAJ3; Ent638_2047.
Other
ProtoNet A4WAJ3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   565  565     NAD-dependent malic enzyme. PRO_1000069531
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   418   418        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 565 AA [This is the length of the unprocessed precursor] Molecular weight: 63216 Da [This is the MW of the unprocessed precursor] CRC64: 2E05AE43311C2F8A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDKKTKKHRS LYIPYAGPVL LEFPLLNKGS AFSAEERSSF NLLGLLPEVV ETIEEQAERA 

        70         80         90        100        110        120 
WIQYQGFKTE IDKHIYLRNI QDTNETLFYR LVQNHLEEMM PVIYTPTVGA ACERFSEIYR 

       130        140        150        160        170        180 
RSRGVFISYE NRHNMDDILQ NVPNHNIKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYT LPVVLDVGTN NQQLLTDPLY MGWRHPRVTD DEYYQFVDDF IQAVKHRWPD 

       250        260        270        280        290        300 
VLLQFEDFAQ KNAMPLLNRY RDEICSFNDD IQGTAAVTAG TLIAASRAAG SQLSYQKIVF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIIAQTQR EGLSEELARS RVFMVDRFGL LTDAMPNLLP FQTKLVQKRE 

       370        380        390        400        410        420 
NLKNWDTDNE VLSLLDVVRN VKPDILIGVS GQTGLFTEEI IREMHKHCER PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEATPQDI IVWTEGNALV ATGSPFDPVI WKDKVYPIAQ CNNSYIFPGI GLGVIASGAS 

       490        500        510        520        530        540 
RITDEMLMSA SETLAQHSPL VKNGEGLVLP ELKDIHIVSR AIAFAVGKMA QQQGVAVKTS 

       550        560 
ADALQQAIDE NFWMPEYRSY RRTSI
A4WAJ3 in FASTA format

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