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UniProtKB/Swiss-Prot entry A4SKE9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_AERS4
Primary accession number A4SKE9
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on May 15, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 14)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: ASA_1264
From
Aeromonas salmonicida (strain A449) [TaxID: 382245] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; Aeromonadaceae; Aeromonas.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Reith M.E., Singh R.K., Curtis B., Boyd J., Bouevitch A., Kimball J., Munholland J., Murphy C., Sarty D., Williams J., Nash J., Johnson S., Brown L.;
"The genome sequence of Aeromonas salmonicida subsp. salmonicida A449.";
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000644; ABO89371.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001141119.1; -.
3D structure databases
ModBase A4SKE9.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A4SKE9.
Genome annotation databases
GeneID 4998452; -.
GenomeReviews CP000644_GR; ASA_1264.
KEGG asa:ASA_1264; -.
CMR A4SKE9; ASA_1264.
Other
ProtoNet A4SKE9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   564  564     NAD-dependent malic enzyme. PRO_1000069526
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   417   417        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 564 AA [This is the length of the unprocessed precursor] Molecular weight: 62521 Da [This is the MW of the unprocessed precursor] CRC64: 21F79D074BEE625B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MFEDNNQKRP LYIPYAGPAL LETPLLNKGC AFTSEERSSF NLEGLLPQNI ETIEEQAERA 

        70         80         90        100        110        120 
YRQFMAFGND LDKHIYLRNI QDTNETLFYR LLHNHLTEML PVIYTPTVGK ACEEFSNIYR 

       130        140        150        160        170        180 
RARGLFISYP DKDRIDDMLQ NATKQNVKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYC LPVVLDVGTN NQQLLSDPFY MGWRNPRISG EEYAEFVDAF IQAVKRRWPD 

       250        260        270        280        290        300 
ILLQFEDFAQ NNAMPLLNRY KNELCCFNDD IQGTAAVTLG SLIAACKASG AKLSEKRVAF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIVAQMKA EGLTDAQARG RVFMVDRFGL ITDKIPNQLD FQRRLSQPVG 

       370        380        390        400        410        420 
RIADWPVGDN ISLLEVMEHG RPDILIGVSG QPGLFTEEVV KTMHKHCTRP IIFPLSNPTS 

       430        440        450        460        470        480 
RVEATPADLI RWTDGQALVA TGSPFAPVEY KGKRYVIAQC NNSFIFPGIG LGVIASGATR 

       490        500        510        520        530        540 
VTDAMLMSAS RALAECSPLV KGAEGSLLPD LADIHQVSRY IAKMVAKTAM LQGKAVQTPD 

       550        560 
EVIDQAIEAN FWRPEYRRYR RTSF
A4SKE9 in FASTA format

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