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UniProtKB/Swiss-Prot entry A4IM31

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_GEOTN
Primary accession number A4IM31
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on May 1, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 15)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: GTNG_1007
From
Geobacillus thermodenitrificans (strain NG80-2) [TaxID: 420246] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0609650104; PubMed=17372208 [NCBI, ExPASy, EBI, Israel, Japan]
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.;
"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000557; ABO66385.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001125130.1; -.
3D structure databases
ModBase A4IM31.
Protein family/group databases
MEROPS M38.972; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
ProDom PD000518; DHOase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; 1.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS A4IM31.
Genome annotation databases
GeneID 4965950; -.
GenomeReviews CP000557_GR; GTNG_1007.
KEGG gtn:GTNG_1007; -.
NMPDR fig|420246.5.peg.976; -.
CMR A4IM31; GTNG_1007.
Other
ProtoNet A4IM31.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   428  428     Dihydroorotase. PRO_1000024085
METAL   61    61        Zinc 1 (By similarity). 
METAL   63    63        Zinc 1 (By similarity). 
METAL   143   143        Zinc 1 (via carbamate group) (By similarity). 
METAL   143   143        Zinc 2 (via carbamate group) (By similarity). 
METAL   180   180        Zinc 2 (By similarity). 
METAL   233   233        Zinc 2 (By similarity). 
METAL   306   306        Zinc 1 (By similarity). 
MOD_RES   143   143        N6-carboxylysine (By similarity). 
Sequence information
Length: 428 AA [This is the length of the unprocessed precursor] Molecular weight: 46453 Da [This is the MW of the unprocessed precursor] CRC64: BD249EB5D54F76BB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAMWLKNGMS FNENGQLVRT HIKIEHGNIA AIHHEQLFEA NGEDVIDVGG KLIAPGLIDV 

        70         80         90        100        110        120 
HVHLREPGGE AKETIETGTL AAAKGGFTTV AAMPNTNPVP DRKEQMEWLA RRIQETAHVR 

       130        140        150        160        170        180 
VLPYASITLG QKGEELTDFA ALKEAGAFAF TDDGVGVQSA GMMFEAMKRA AALDMAIVAH 

       190        200        210        220        230        240 
CEDDTLKNGG AVHDGDFARR YGIAGIPSVC EAVHIARDVL LAEATGCHYH VCHISTKESV 

       250        260        270        280        290        300 
RVVRDAKRAG ICVTAEVTPH HLLLCDEDIP RLDANYKMNP PLRSRADREA LIEGLLDGTI 

       310        320        330        340        350        360 
DFIATDHAPH TAAEKAKGME AAPFGIVGLE TAFPLLYTHF VKKNVFTLKQ LVDWLTIKPA 

       370        380        390        400        410        420 
QCFGLQTGRL EVGAPADITV IDLETEEPID PETFASKGNN TPFAGWRCQG WPVMTFVGGT 


LVWEKGRA
A4IM31 in FASTA format

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