FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000609; ABO35953.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001098167.1; -.

3D structure databases

ModBase

A4G0G9.

Ontologies

GO:0008408;	Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738;	Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261;	Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00324; -; 1.
PBIL [Tree]

InterPro

IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.

Pfam

PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF016275; PolC_DP2; 1.

TIGRFAMs

TIGR00354; polC; 1.

BLOCKS

A4G0G9.

Genome annotation databases

GeneID

4928217; -.

GenomeReviews

CP000609_GR; MmarC5_1656.

KEGG

mmq:MmarC5_1656; -.

CMR

A4G0G9; MmarC5_1656.

Other

ProtoNet

A4G0G9.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1131`	`1131`		`DNA polymerase II large subunit.`	`PRO_1000019389`

Sequence information

Length: 1131 AA [This is the length of the unprocessed precursor]

Molecular weight: 128289 Da [This is the MW of the unprocessed precursor]

CRC64: 7D2826B4CE998567 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLHVSASKGM TEYFKNILDN VKNLYDLAEG CRKSGYDVTD HVEIPLAKDM ADRVEGIVGP 

        70         80         90        100        110        120 
KNVAERIREL VSDLGKEPAA LEIAKEIVEG KFGEFGREVG AEQAVRTALA VITEGIVAAP 

       130        140        150        160        170        180 
LEGIAHVKIK KNNDGGEYLA IYFAGPIRSA GGTAQALAVL VGDYVRKNMG LDKFKPTDDE 

       190        200        210        220        230        240 
VERYGEEVDL YQSEVTTFQY QPKAEEIRVA VRNISVEITG EATDDVEVSG HRDLPRIETN 

       250        260        270        280        290        300 
QIRGGALLAL VEGVLLKAPK ILRHVDKLGI EGWDWLKELK SKKEELVEEI EEENDEFNYE 

       310        320        330        340        350        360 
EEEDLSQYED YEVEAVTKFI GEVIAGRPVF SHPSKKGGFR LRYGRSRNTG FATDGFHPAI 

       370        380        390        400        410        420 
MYLVDDFMAV GTQLKTERPG KATCVVPVDS IEGPIVKLND KSVLKIDTVE KAKQYRDDVE 

       430        440        450        460        470        480 
EILFLGDILV NYGDFLENNH TILPSSWCTE WYEKILKSEN LEYTKEFIEN PDQKEVVKYA 

       490        500        510        520        530        540 
KLTNTPLHPK YTYFWHDISK DNINVLRNWI IGGRYNESND SWGLTYDPED PEISIVKRYL 

       550        560        570        580        590        600 
ELIGCPHTVV DEKVEIFEYY PLLYSLGYDF DEKQDVVEDI EEKLQNTKNN MHFINTIAPF 

       610        620        630        640        650        660 
EIRRNAYIYV GARMGRPEKA ASRKMKPPVN GLFPIGNAGA LVRLINKAVD EGKTDEIEIS 

       670        680        690        700        710        720 
NVKCSCGNVS LYRTCPFCGS SVEPSGPSRI KLPIKEYWYK ALENLKINKA GDVKCIKGMT 

       730        740        750        760        770        780 
SKDKIIEPLE KAILRAKNDI FVFKDGTTRF DCTDVPVTHF RPVEIHGDIE KLKSLGYLKD 

       790        800        810        820        830        840 
IHGNPLENEN QVLELNVQDV IVPESCMDYF LNVSKFIDDL LEKYYKKDRF YNVNKREELV 

       850        860        870        880        890        900 
GHLIIGMAPH TSAGMVGRII GYSKANVGYA HPYFHASKRR NCDGDEDAFF LLLDAFMNFS 

       910        920        930        940        950        960 
KRFLPDKRGG QMDAPLVLTT ILDPKEVDGE VHNMDSMWEY PLEFYEKSLE GIAPKEIKKI 

       970        980        990       1000       1010       1020 
METVEDRLDK ESQYEGIGYT HETLKIDEGP LVCAYKTLGS MMEKTSAQLA VAKKIRATDE 

      1030       1040       1050       1060       1070       1080 
RDVAEKVIQS HFVPDLIGNL RAFSRQGVRC KCGAKYRRMP LKGICRKCGS RLILTVSKGA 

      1090       1100       1110       1120       1130 
VEKYMDVSQT MAEKYNASDY IKQRLEIIRS GIDSLFVNDK RKQVKIEDFF K

A4G0G9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools