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UniProtKB/Swiss-Prot entry A3N3E9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ILVC_ACTP2
Primary accession number A3N3E9
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on April 3, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 15)
Name and origin of the protein
Protein name Ketol-acid reductoisomerase
Synonyms EC 1.1.1.86
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacil reductoisomerase
Gene name
Name: ilvC
OrderedLocusNames: APL_1853
From
Actinobacillus pleuropneumoniae serotype 5b (strain L20) [TaxID: 416269] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales; Pasteurellaceae; Actinobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1128/JB.01845-07; PubMed=18065534 [NCBI, ExPASy, EBI, Israel, Japan]
Foote S.J., Bosse J.T., Bouevitch A.B., Langford P.R., Young N.M., Nash J.H.E.;
"The complete genome sequence of Actinobacillus pleuropneumoniae L20 (serotype 5b).";
J. Bacteriol. 190:1495-1496(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000569; ABN74935.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001054540.1; -.
3D structure databases
SMR A3N3E9; 3-490.
ModBase A3N3E9.
Ontologies
GO
GO:0004455; Molecular function: ketol-acid reductoisomerase activity (inferred from electronic annotation from HAMAP).
GO:0009097; Biological process: isoleucine biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0009099; Biological process: valine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00435; -; 1.
PBIL [Tree]
InterPro IPR013023; AcH_isomrdctse.
IPR000506; AcH_isomrdctse_C.
IPR013116; IlvN.
IPR014359; KetolA_reductoisomerase_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR21371; AcH_isomrdctse; 1.
Pfam PF01450; IlvC; 1.
PF07991; IlvN; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000116; IlvC_gammaproteo; 1.
TIGRFAMs TIGR00465; ilvC; 1.
BLOCKS A3N3E9.
Genome annotation databases
GeneID 4849756; -.
GenomeReviews CP000569_GR; APL_1853.
KEGG apl:APL_1853; -.
CMR A3N3E9; APL_1853.
Other
ProtoNet A3N3E9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   493  493     Ketol-acid reductoisomerase. PRO_1000050473
ACT_SITE   132   132        Potential. 
Sequence information
Length: 493 AA [This is the length of the unprocessed precursor] Molecular weight: 54393 Da [This is the MW of the unprocessed precursor] CRC64: C3C0305A17739780 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MANYFNTLNL RQKLDQLGRC RFMDRNEFAD GCNFLKGKKI VIVGCGAQGL NQGLNMRDSG 

        70         80         90        100        110        120 
LDISYALRAE AIAEKRASFT RATENGFKVG TYQELIPTAD LVINLTPDKQ HSKVVADVVP 

       130        140        150        160        170        180 
LMKQGSAFGY SHGFNIVEEG EQIRKDITVV MTAPKCPGTE VREEYKRGFG VPTLIAVHPE 

       190        200        210        220        230        240 
NDPKGEGMAI AKAWASATGG DRAGVLESSF VAEVKSDLMG EQTILCGMLQ AGSIVCYDKL 

       250        260        270        280        290        300 
VADGKDPAYA SKLIQYGWET ITEALKQGGI TLMMDRLSNA AKIRAFELSE EIKVQLNDLY 

       310        320        330        340        350        360 
LKHMDDIISG EFSSTMMADW ANGDVNLFKW REETGKTAFE NSPKADGIKI SEQEYFDNGV 

       370        380        390        400        410        420 
VMVAMVKAGV EMAFDAMVAS GIYEESAYYE SLHELPLIAN TIARKRLYEM NVVISDTAEY 

       430        440        450        460        470        480 
GNYLFSHVAT PILAEKLIPM LQKGDLGEPT PAAEIDNVYL RDINDAIRNH PVELIGQELR 

       490 
GYMTDMKRIS SQG
A3N3E9 in FASTA format

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