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UniProtKB/Swiss-Prot entry A3M928

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ACIBT
Primary accession number A3M928
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on July 10, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 13)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: A1S_3025
From
Acinetobacter baumannii (strain ATCC 17978 / NCDC KC 755) [TaxID: 400667] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gad.1510307; PubMed=17344419 [NCBI, ExPASy, EBI, Israel, Japan]
Smith M.G., Gianoulis T.A., Pukatzki S., Mekalanos J.J., Ornston L.N., Gerstein M., Snyder M.;
"New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis.";
Genes Dev. 21:601-614(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000521; ABO13422.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001086024.1; -.
3D structure databases
SMR A3M928; 1-299.
ModBase A3M928.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; FALSE_NEG.
BLOCKS A3M928.
Genome annotation databases
GeneID 4917602; -.
GenomeReviews CP000521_GR; A1S_3025.
KEGG acb:A1S_3025; -.
NMPDR fig|400667.4.peg.3130; -.
CMR A3M928; A1S_3025.
Other
ProtoNet A3M928.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   328  328     Malate dehydrogenase. PRO_0000294371
NP_BIND   11    17  7     NAD (By similarity). 
NP_BIND   131   133  3     NAD (By similarity). 
ACT_SITE   189   189        Proton acceptor (By similarity). 
BINDING   94    94        Substrate (By similarity). 
BINDING   100   100        Substrate (By similarity). 
BINDING   107   107        NAD (By similarity). 
BINDING   114   114        NAD (By similarity). 
BINDING   133   133        Substrate (By similarity). 
BINDING   164   164        Substrate (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 35323 Da [This is the MW of the unprocessed precursor] CRC64: 4A3ABDD04F615F6E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKQPVRVAVT GAAGQIGYSL LFRIASGEML GKDQPVILQL LEVPVEKAQQ ALKGVMMELD 

        70         80         90        100        110        120 
DCAFPLLAGM IGTDDPKVAF KDADYALLVG SRPRGPGMER ADLLKVNGEI FIGQGQALNE 

       130        140        150        160        170        180 
VASRDVKVLV VGNPANTNAY IAMKSAPDLP AKNFTAMLRL DHNRALTQVA QKAGVAVADI 

       190        200        210        220        230        240 
EKLTVWGNHS PTMYADYRFA TANGESLKDK INDPAWNKDV FLPTVGKRGA AIIEARGLSS 

       250        260        270        280        290        300 
AASAANAAID HMRDWALGTN GKWVTMGVPS DGSYGIPEGV MFGFPVTTEN GEYKIVQGLE 

       310        320 
IDEFSRERIN FTLNELEEER AAIADMVK
A3M928 in FASTA format

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