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UniProtKB/Swiss-Prot entry A1W9K7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ACISJ
Primary accession number A1W9K7
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on June 26, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 12)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: Ajs_2791
From
Acidovorax sp. (strain JS42) [TaxID: 232721] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Acidovorax.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chertkov O., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Stahl D., Richardson P.;
"Complete sequence of chromosome 1 of Acidovorax sp. JS42.";
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000539; ABM42932.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_987008.1; -.
3D structure databases
SMR A1W9K7; 25-350.
ModBase A1W9K7.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; FALSE_NEG.
BLOCKS A1W9K7.
Genome annotation databases
GeneID 4674373; -.
GenomeReviews CP000539_GR; Ajs_2791.
KEGG ajs:Ajs_2791; -.
CMR A1W9K7; Ajs_2791.
Other
ProtoNet A1W9K7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   328  327     Malate dehydrogenase. PRO_0000292367
NP_BIND   12    18  7     NAD (By similarity). 
NP_BIND   132   134  3     NAD (By similarity). 
ACT_SITE   190   190        Proton acceptor (By similarity). 
BINDING   95    95        Substrate (By similarity). 
BINDING   101   101        Substrate (By similarity). 
BINDING   108   108        NAD (By similarity). 
BINDING   115   115        NAD (By similarity). 
BINDING   134   134        Substrate (By similarity). 
BINDING   165   165        Substrate (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 34838 Da [This is the MW of the unprocessed precursor] CRC64: A02967E44E7FA9BD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSKKPVRVAV TGAAGQIGYA LLFRIASGEM LGKDQPVILQ LLEIPDEKAQ NALKGVIMEL 

        70         80         90        100        110        120 
EDCAFPLLAG IEAHSDPMTA FKDTDYALLV GARPRGPGME RADLLAANAQ IFTAQGKALN 

       130        140        150        160        170        180 
AVASRNVKVL VVGNPANTNA YIAMKSAPDL PAKNFTAMLR LDHNRAASQL AAKGGFKVGD 

       190        200        210        220        230        240 
IKKLTVWGNH SPTMYADYRF ATVDGKSVKD AINDPAWYKD VFLPTVGKRG AAIIAARGLS 

       250        260        270        280        290        300 
SAASAANAAI DHMRDWALGS KGEWVTMGVP SNGEYGIPAG IVFGFPVTTE NGEYKIVEGL 

       310        320 
PIDAFSQECI DKTLAELQGE QDGVKHLL
A1W9K7 in FASTA format

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