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UniProtKB/Swiss-Prot entry A1UK81

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KGD_MYCSK
Primary accession number A1UK81
Secondary accession numbers None
Integrated into Swiss-Prot on November 13, 2007
Sequence was last modified on February 6, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 18)
Name and origin of the protein
Protein name 2-oxoglutarate decarboxylase
Synonyms EC 4.1.1.71
Alpha-ketoglutarate decarboxylase
2-oxoglutarate carboxy-lyase
Gene name
Name: kgd
OrderedLocusNames: Mkms_4047
From
Mycobacterium sp. (strain KMS) [TaxID: 189918] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D., Richardson P.;
"Complete sequence of chromosome of Mycobacterium sp. KMS.";
Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000518; ABL93239.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_940029.1; -.
3D structure databases
ModBase A1UK81.
Ontologies
GO
GO:0008683; Molecular function: 2-oxoglutarate decarboxylase activity (inferred from electronic annotation from EC).
GO:0008415; Molecular function: acyltransferase activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004591; Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from electronic annotation from InterPro).
GO:0030976; Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from InterPro).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001078; 2Oxoacid_DHase.
IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.
PANTHER PTHR23152; 2oxoglutarate_DH_E1; 1.
Pfam PF00198; 2-oxoacid_dh; 1.
PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000157; Oxoglu_dh_E1; 1.
ProDom PD001115; 2Oxoacid_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00239; 2oxo_dh_E1; 1.
Genome annotation databases
GeneID 4611987; -.
GenomeReviews CP000518_GR; Mkms_4047.
KEGG mkm:Mkms_4047; -.
CMR A1UK81; Mkms_4047.
Other
ProtoNet A1UK81.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Coiled coil; Complete proteome; Decarboxylase; Lyase; Magnesium; Thiamine pyrophosphate; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1269  1269     2-oxoglutarate decarboxylase. PRO_0000310720
COILED   824    855  32     Potential. 
Sequence information
Length: 1269 AA [This is the length of the unprocessed precursor] Molecular weight: 140119 Da [This is the MW of the unprocessed precursor] CRC64: F6F4221B80E76B83 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSSPSPFGQ NEWLVEEMYR KFREDPSSVD PSWHEFLVDY NPEPTTDSSA SENGQQTRTA 

        70         80         90        100        110        120 
APKAPPEPAP APAPKTPDSK TPDSKSQAPK QDSKPQESKP QAKAKPAESK SSTKPADAKS 

       130        140        150        160        170        180 
EKSGKSGTNG AAKPAAQPAD DSDQNQVLRG AAAAVAKNMS ASLDVPTATS VRAIPAKLMI 

       190        200        210        220        230        240 
DNRVVINNHL KRTRGGKISF THLIGYAIVA AVKKFPNMNR HFAEVDGKPN AVTPAHTNLG 

       250        260        270        280        290        300 
LAIDLQGKDG NRQLVVAAIK KADTMRFGQF IAAYEDIVRR ARDGKLTAED FSGVTISLTN 

       310        320        330        340        350        360 
PGTIGTVHSV PRLMRGQGAI IGVGAMEYPA EFQGASEERI ADLGIGKLIT LTSTYDHRII 

       370        380        390        400        410        420 
QGAESGDFLR TVHQLLLSDD FFDEIFRELG IPYEPVRWRT DNPDSIEDKN ARVIELIAAY 

       430        440        450        460        470        480 
RNRGHLMADI DPLRLDSNRF RSHPDLDVLT HGLTLWDLDR EFKVNGFAGA ERKKLRDVLA 

       490        500        510        520        530        540 
VLRDAYCRHI GVEYTHILEP EQQQWLQERI EGKHEKPTVA QQKYILSRLN AAEAFETFLQ 

       550        560        570        580        590        600 
TKYVGQKRFS LEGAETVIPA MDAVIDQCAE HALDEVVIGM PHRGRLNVLA NIVGKPYSQI 

       610        620        630        640        650        660 
FSEFEGNLNP SQAHGSGDVK YHLGSSGTYL QMFGDNDITV SLTANPSHLE AVDPVMEGLV 

       670        680        690        700        710        720 
RAKQDLLDKG DTEDGYTVVP LMLHGDAAFA GQGVVAETLN LALLRGYRTG GTIHLIVNNQ 

       730        740        750        760        770        780 
IGFTTSPAAA KSSEYCTDVA KMIGAPIFHV NGDDPEAAVW VSRLAVDFRQ KFKKDVVIDL 

       790        800        810        820        830        840 
LCYRRRGHNE GDDPSMTQPS MYDVIDTKRG VRKSYTEALI GRGDISMKEA EDALRDYQGQ 

       850        860        870        880        890        900 
LEQVFNEVRE LEKHEIEPSE SVEADQQIPA KLATAVDKSL LARIGDAHLA VPEGFTVHPR 

       910        920        930        940        950        960 
VKPVLEKRRE MAYEGKVDWA FAELLALGTM ISEGKLVRLS GQDTRRGTFT QRHSVVIDRK 

       970        980        990       1000       1010       1020 
TGKEFTPLQL LATDSDGNPT GGKFLVYDSP LSEFAAVGFE YGYSVGNPDA MVLWEAQFGD 

      1030       1040       1050       1060       1070       1080 
FINGAQSIID EFISSGEAKW GQLSDVVLLL PHGHEGQGPD HTSGRIERFL QLWAEGSMTI 

      1090       1100       1110       1120       1130       1140 
ALPSTPANYF HLLRRHSLDG IQRPLIVFTP KSMLRNKAAV SDIRDFTEQK FRSVLEEPTY 

      1150       1160       1170       1180       1190       1200 
TDGDGDRNKV TRILLTSGKI YYELVARKNK ESRDDVAIVR IEQLAPLPKR RLAETLDKYP 

      1210       1220       1230       1240       1250       1260 
NVEEKFWVQE EPANQGAWPT FGLTLPEMLP DHFTGIKRIS RRAMSAPSSG SSKVHAVEQQ 


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A1UK81 in FASTA format

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