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UniProtKB/Swiss-Prot entry A1R2B5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_ARTAT
Primary accession number A1R2B5
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on February 6, 2007 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 15)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: AAur_0570
From
Arthrobacter aurescens (strain TC1) [TaxID: 290340] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Micrococcineae; Micrococcaceae; Arthrobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0020214; PubMed=17194220 [NCBI, ExPASy, EBI, Israel, Japan]
Mongodin E.F., Shapir N., Daugherty S.C., DeBoy R.T., Emerson J.B., Shvartzbeyn A., Radune D., Vamathevan J., Riggs F., Grinberg V., Khouri H.M., Wackett L.P., Nelson K.E., Sadowsky M.J.;
"Secrets of soil survival revealed by the genome sequence of Arthrobacter aurescens TC1.";
PLoS Genet. 2:2094-2106(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000474; ABM08217.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_946377.1; -.
3D structure databases
ModBase A1R2B5.
Ontologies
GO
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01517; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR010945; Malate_DHase_SF1.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23382; MDH_SF1; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
ProDom PD003052; Mal_dehydrog; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01759; MalateDH-SF1; 1.
PROSITE PS00068; MDH; 1.
BLOCKS A1R2B5.
Genome annotation databases
GeneID 4638819; -.
GenomeReviews CP000474_GR; AAur_0570.
KEGG aau:AAur_0570; -.
TIGR AAur_0570; -.
Other
ProtoNet A1R2B5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   328  328     Malate dehydrogenase. PRO_0000292368
NP_BIND   11    17  7     NAD (By similarity). 
NP_BIND   129   131  3     NAD (By similarity). 
ACT_SITE   187   187        Proton acceptor (By similarity). 
BINDING   92    92        Substrate (By similarity). 
BINDING   98    98        Substrate (By similarity). 
BINDING   105   105        NAD (By similarity). 
BINDING   112   112        NAD (By similarity). 
BINDING   131   131        Substrate (By similarity). 
BINDING   162   162        Substrate (By similarity). 
Sequence information
Length: 328 AA [This is the length of the unprocessed precursor] Molecular weight: 34378 Da [This is the MW of the unprocessed precursor] CRC64: 52DA63DC35988ED1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSSPIKIAVT GAAGQIGYSL LFRIASGALF GGDTPVQLRL LEITPALKAL EGVVMELDDC 

        70         80         90        100        110        120 
AFPALDSVEI GDDADHIFDG VTLALLVGAR PRSKGMERGD LLSANGAIFT AQGKALNRVA 

       130        140        150        160        170        180 
ADDVRIGVTG NPANTNALIA MSNAPDIPAS RFSALTRLDH NRAIGQLAAK THARVGDIRK 

       190        200        210        220        230        240 
MTVWGNHSAT QYPDIFHAEV AGRNAAEVVN DQDWIENEFI PTVAGRGAAI IEARGASSAA 

       250        260        270        280        290        300 
SAASATIDAA RDWLLGTPEG DWVSMAVASD GSYGVPEGLM YSYPVTTSGG NWEIVEGLEV 

       310        320 
NDFSRRKMDA TAAELFDERA AVANLGLI
A1R2B5 in FASTA format

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