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UniProtKB/Swiss-Prot entry A1A5B4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ANO9_HUMAN
Primary accession number A1A5B4
Secondary accession numbers B3KUC4 B4E134 Q8TEN4
Integrated into Swiss-Prot on May 29, 2007
Sequence was last modified on March 3, 2009 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 22)
Name and origin of the protein
Protein name Anoctamin-9
Synonyms Transmembrane protein 16J
Tumor protein p53-inducible protein 5
p53-induced gene 5 protein
Gene name
Name: ANO9
Synonyms: PIG5, TMEM16J, TP53I5
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS VAL-391 AND ARG-399.
TISSUE=Spleen;
DOI=10.1093/dnares/10.1.49; PubMed=12693554 [NCBI, ExPASy, EBI, Israel, Japan]
Jikuya H., Takano J., Kikuno R., Hirosawa M., Nagase T., Nomura N., Ohara O.;
"Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.";
DNA Res. 10:49-57(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND VARIANTS LEU-93; VAL-391 AND ARG-399.
TISSUE=Salivary gland, and Thymus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04632; PubMed=16554811 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene identification.";
Nature 440:497-500(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-93; VAL-391 AND ARG-399.
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION AS PUTATIVE CHLORIDE CHANNEL.
DOI=10.1038/nature07313; PubMed=18724360 [NCBI, ExPASy, EBI, Israel, Japan]
Yang Y.D., Cho H., Koo J.Y., Tak M.H., Cho Y., Shim W.-S., Park S.P., Lee J., Lee B., Kim B.-M., Raouf R., Shin Y.K., Oh U.;
"TMEM16A confers receptor-activated calcium-dependent chloride conductance.";
Nature 455:1210-1215(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK074088; BAB84914.1; ALT_SEQ; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK096874; BAG53386.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK303642; BAG64646.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC138230; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
BC128557; AAI28558.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00152780; -.
IPI00922125; -.
IPI00922523; -.
RefSeq NP_001012302.2; -.
UniGene Hs.501622
3D structure databases
ModBase A1A5B4.
Organism-specific databases
GeneCards GC11M000409; -.
HGNC HGNC:20679; ANO9.
GenAtlas ANO9.
PharmGKB PA134898400; -.
Gene expression databases
Bgee A1A5B4; -.
CleanEx HS_ANO9; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005254; Molecular function: chloride channel activity (inferred from electronic annotation from UniProtKB-KW).
GO:0031404; Molecular function: chloride ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006811; Biological process: ion transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR007632; DUF590.
Graphical view of domain structure.
PANTHER PTHR12308; DUF590; 1.
Pfam PF04547; DUF590; 1.
Pfam graphical view of domain structure.
Genome annotation databases
Ensembl ENSG00000185101; Homo sapiens. [Contig view]
GeneID 338440; -.
KEGG hsa:338440; -.
Phylogenomic databases
HOVERGEN A1A5B4; -.
OMA A1A5B4; KCRSLRA.
Other
NextBio 97010; -.
ProtoNet A1A5B4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Calcium; Chloride; Chloride channel; Ion transport; Ionic channel; Membrane; Polymorphism; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   782  782     Anoctamin-9. PRO_0000289329
TRANSMEM   199   219  21     Potential. 
TRANSMEM   265   285  21     Potential. 
TRANSMEM   332   352  21     Potential. 
TRANSMEM   374   394  21     Potential. 
TRANSMEM   424   444  21     Potential. 
TRANSMEM   553   573  21     Potential. 
TRANSMEM   605   625  21     Potential. 
TRANSMEM   704   724  21     Potential. 
VAR_SEQ   1   299        Missing (in isoform 2). VSP_036489
VAR_SEQ   156   186        GEGRLKKTWARWRHMFREQPVDEIRNYFGEK -> VRGGPAWRGPWGGTLGWGLSLSVTRARGRDA (in isoform 3). VSP_036490
VAR_SEQ   187   782        Missing (in isoform 3). VSP_036491
VAR_SEQ   300   305        VWDEEQ -> MPAVSE (in isoform 2). VSP_036492
VARIANT   93    93  1     F -> L (in dbSNP:rs7395065 [NCBI]). VAR_054621 
VARIANT   391   391  1     I -> V (in dbSNP:rs10794324 [NCBI]). VAR_032617 
VARIANT   399   399  1     C -> R (in dbSNP:rs10794323 [NCBI]). VAR_032618 
Sequence information
Length: 782 AA [This is the length of the unprocessed precursor] Molecular weight: 90367 Da [This is the MW of the unprocessed precursor] CRC64: C319076A5C1433FF [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQGEESLRIL VEPEGDSFPL MEISTCETEA SEQWDYVLVA QRHTQRDPRQ ARQQQFLEEL 

        70         80         90        100        110        120 
RRKGFHIKVI RDQKQVFFGI RADNSVFGLY RTFLLEPEGP APHAELAAPT TIPVTTSLRI 

       130        140        150        160        170        180 
RIVNFVVMNN KTSAGETFED LMKDGVFEAR FPLHKGEGRL KKTWARWRHM FREQPVDEIR 

       190        200        210        220        230        240 
NYFGEKVALY FVWLGWYTYM LVPAALTGLL VFLSGFSLFE ASQISKEICE AHDILMCPLG 

       250        260        270        280        290        300 
DHSRRYQRLS ETCTFAKLTH LFDNDGTVVF AIFMALWATV FLEIWKRQRA RVVLHWDLYV 

       310        320        330        340        350        360 
WDEEQEEMAL QLINCPDYKL RPYQHSYLRS TVILVLTLLM ICLMIGMAHV LVVYRVLASA 

       370        380        390        400        410        420 
LFSSSAVPFL EEQVTTAVVV TGALVHYVTI IIMTKINRCV ALKLCDFEMP RTFSERESRF 

       430        440        450        460        470        480 
TIRFFTLQFF THFSSLIYIA FILGRINGHP GKSTRLAGLW KLEECHASGC MMDLFVQMAI 

       490        500        510        520        530        540 
IMGLKQTLSN CVEYLVPWVT HKCRSLRASE SGHLPRDPEL RDWRRNYLLN PVNTFSLFDE 

       550        560        570        580        590        600 
FMEMMIQYGF TTIFVAAFPL APLLALFSNL VEIRLDAIKM VWLQRRLVPR KAKDIGTWLQ 

       610        620        630        640        650        660 
VLETIGVLAV IANGMVIAFT SEFIPRVVYK YRYSPCLKEG NSTVDCLKGY VNHSLSVFHT 

       670        680        690        700        710        720 
KDFQDPDGIE GSENVTLCRY RDYRNPPDYN FSEQFWFLLA IRLAFVILFE HVALCIKLIA 

       730        740        750        760        770        780 
AWFVPDIPQS VKNKVLEVKY QRLREKMWHG RQRLGGVGAG SRPPMPAHPT PASIFSARST 


DV 

A1A5B4 in FASTA format

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