FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase (By similarity).
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
CATALYTIC ACTIVITY: Degradation of single-stranded DNA. It acts progressively in a 3'- to 5'-direction, releasing nucleoside 5'-phosphates.
SUBUNIT: Heterodimer of a large subunit and a small subunit (By similarity).
SIMILARITY: Belongs to the archaeal DNA polymerase II family.

Copyright

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Cross-references

Sequence databases

EMBL

DP000238; ABK78437.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

A0RYM0.

Ontologies

GO:0008408;	Molecular function: 3'-5' exonuclease activity (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from HAMAP).
GO:0003887;	Molecular function: DNA-directed DNA polymerase activity (inferred from electronic annotation from HAMAP).
GO:0000738;	Biological process: DNA catabolic process, exonucleolytic (inferred from electronic annotation from HAMAP).
GO:0006261;	Biological process: DNA-dependent DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00324; -; 1.
PBIL [Tree]

InterPro

IPR004475; PolC_DP2.
IPR016033; PolC_DP2_N.
Graphical view of domain structure.

Pfam

PF03833; PolC_DP2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00354; polC; 1.

BLOCKS

A0RYM0.

Genome annotation databases

GenomeReviews

DP000238_GR; CENSYa_1827.

CMR

A0RYM0; CENSYa_1827.

Other

ProtoNet

A0RYM0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; DNA replication; DNA-binding; DNA-directed DNA polymerase; Exonuclease; Hydrolase; Multifunctional enzyme; Nuclease; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 1112`	`1112`		`DNA polymerase II large subunit.`	`PRO_0000294676`

Sequence information

Length: 1112 AA [This is the length of the unprocessed precursor]

Molecular weight: 121039 Da [This is the MW of the unprocessed precursor]

CRC64: BA05392302C4ECF4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSGGDVEEYL RGADMPEEYR RYYSSLSGGT YDIFEKAASA KSNLADSSGM VEPKIAVDLS 

        70         80         90        100        110        120 
DRVAKMHDLD IAGPLRELLA TKGKELAALM LAKEIMDGKY LPEADIEKRI DSAVRVGLAV 

       130        140        150        160        170        180 
VTEGVTIAPL QGIADVITKK NKDGSEYLSV SIAGPMRSAG GTESAVTMLI ADYVRRQAGL 

       190        200        210        220        230        240 
AEYQADSLDD ETGRFIEELR IYEREVGSFQ FHVLDEDIRA VISHLPVELD GVDTDPYEVV 

       250        260        270        280        290        300 
NHKGMSRIQT DRVRGGALRV LNDGLIGRSK KLLKRIELYG LDGWEWLAEL KGAVQTGENK 

       310        320        330        340        350        360 
EDAAAKRMRE VITGRSVLSM PNRLGGFRLR YGRACNTGYT SVGFHPAVAE ILDHTIAVGT 

       370        380        390        400        410        420 
QVKIDIPGKG ATVAFVDTIE APTVRLAGGD VVKIRDVAHG IELKGSIERI LHLGDMLISF 

       430        440        450        460        470        480 
GDFLENNAQL VPSGYVEEIW KMDMEAAGAA QGSPSSADEA VRISRELGVP LHPRYLYYWD 

       490        500        510        520        530        540 
QISHEELAML LSPLDKGDAI SYPAACKPVL EKLGVPHKAG PEGPVLEGDE ARIFRELILD 

       550        560        570        580        590        600 
NPPGPDASAP VPELISRSSG ITIRDKFSTS IGVRIGRPEK AAPRQMRPPT HCLFPVGGTG 

       610        620        630        640        650        660 
GPTNNLLKSA ARPGFSADIL SRRCPGCGEP SISIRCWACG ERTAVERTCM QCGTDVDGEE 

       670        680        690        700        710        720 
CERCGRPGLA HSRVEFPLKK MLVSAQEKTG VRAHDPLKGV KELAHQDRIA EPLEKGLIRQ 

       730        740        750        760        770        780 
SRSLTVFKDG TVRFDATNSP MTHFKPSWIG TSAEKLRELG YETDVDGKKL EGPDQLVELR 

       790        800        810        820        830        840 
MQDIVIPLEG AKYLVSACGY IDAELDKLYG APPFYKVPDL GGLIGHLVVG LAPHTSVGVA 

       850        860        870        880        890        900 
ARIIGYTETH VCFGTPNWHS AKRRDADGDA DSIILLMDAL LNFSRHYLSD RIGGLMDAPL 

       910        920        930        940        950        960 
LIQPLVLPHE SQSQAHNIEV VKRLPPGFYE AAAARKKASE VGCVEIVKSR LETAGQFGGY 

       970        980        990       1000       1010       1020 
HFTHGTSSLT TSRPRSAYST LGSMLDKLDL QIRNANLIAA VDAAEIISNV ISTHLVPDIM 

      1030       1040       1050       1060       1070       1080 
GNLRAYARQN FRCTACGKSY RRIPLAQRCS CGNGLIQTIT RASVEKYLKL AKRLVNEYDV 

      1090       1100       1110 
GAYQRGRIHA LSDEIELVFG KGGGDQALLT DF

A0RYM0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools